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Selective blockade of the antigen-receptor-mediated pathway of T cell activation in patients with impaired primary immune responses.
S C Meuer, … , K H Meyer zum Büschenfelde, H Köhler
S C Meuer, … , K H Meyer zum Büschenfelde, H Köhler
Published September 1, 1987
Citation Information: J Clin Invest. 1987;80(3):743-749. https://doi.org/10.1172/JCI113129.
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Research Article

Selective blockade of the antigen-receptor-mediated pathway of T cell activation in patients with impaired primary immune responses.

Abstract

We investigated impaired cellular immune responses of individuals on chronic hemodialysis by using monoclonal antibodies that trigger differential pathways of T cell activation. Reduced cellular reactivity, which exists in a high proportion of such patients, can be attributed to a failure of the monocyte population to support the process of primary T cell activation in vitro. This defect results in a lack of interleukin 2 production, which is critically dependent on a monocyte-derived signal. In contrast, T lymphocyte function was found to be physiologic. Perhaps more important, the degree of monocyte dysfunction in vitro correlated with the same patients' in vivo responses to hepatitis B vaccination. Addition of recombinant human interleukin 2 fully reconstituted their deficient immune response in vitro.

Authors

S C Meuer, M Hauer, P Kurz, K H Meyer zum Büschenfelde, H Köhler

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