Increased alveolar surface tension due to surfactant deficiency is thought to result in a negative pressure surrounding pulmonary capillaries and to promote fluid filtration. To test this hypothesis, alveolar liquid pressure (Pliquid) was measured by micropuncture in isolated lungs of mature and immature fetal rabbits (with and without surfactant replacement) at different air inflation pressures (Pairway). Lung maturity was assessed by air pressure-volume (P-V) curves. Pliquid was correlated with surfactant content in the lungs and with alveolar size. Pliquid was lower in immature (2.3 +/- 0.7 cmH2O) than in mature (8.4 +/- 1.0 cmH2O) lungs at comparable Pairway (25 cmH2O) (P less than 0.01). The mean linear intercept, a measure of airspace dimensions was similar in all lungs (42.1 +/- 2.0 micron), but alveolar wash phospholipid/g wet lung was lower in immature than in mature lungs (0.05 +/- 0.01 vs. 0.49 +/- 0.30 mg) (P less than 0.01). Surfactant replacement in immature lungs resulted in P-V curves and Pliquid similar to those of mature lungs. If pericapillary interstitial liquid pressure approximates Pliquid, surfactant deficiency will predispose preterm infants to pulmonary edema.
J U Raj
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Life-Saving Impact of Pulmonary Surfactant Therapy in Premature Babies
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Journal of Clinical Investigation | 2024 |
Computational pulmonary edema: A microvascular model of alveolar capillary and interstitial flow.
Grotberg JB, Romanò F |
2023 | |
Computational pulmonary edema: A microvascular model of alveolar capillary and interstitial flow.
Grotberg JB, Romanò F |
2022 | |
Lung Microvascular Niche, Repair, and Engineering
T Tsuchiya, R Doi, T Obata, G Hatachi, T Nagayasu |
Frontiers in Bioengineering and Biotechnology | 2020 |
Regulation and Repair of the Alveolar-Capillary Barrier in Acute Lung Injury
J Bhattacharya, MA Matthay |
Annual Review of Physiology | 2013 |
Kendig & Chernickâs Disorders of the Respiratory Tract in Children
SH Abman |
Kendig & Chernickâs Disorders of the Respiratory Tract in Children | 2012 |
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JL Aschner, CD Fike |
The Newborn Lung | 2008 |
Kendig's Disorders of the Respiratory Tract in Children
SH Abman, JM Davis |
Kendig's Disorders of the Respiratory Tract in Children | 2006 |
Role of veins in regulation of pulmonary circulation
Y Gao, JU Raj |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
The Lung
KH Albertine, TJ Psysher |
The Lung | 2004 |
Chronic Lung Injury in Preterm Lambs: Abnormalities of the Pulmonary Circulation and Lung Fluid Balance
RD Bland, KH Albertine, DP Carlton, L Kullama, P Davis, SC Cho, BI Kim, M Dahl, N Tabatabaei |
Pediatric Research | 2000 |
Chronic Lung Injury in Preterm Lambs: Abnormalities of the Pulmonary Circulation and Lung Fluid Balance:
RD Bland, KH Albertine, DP Carlton, L Kullama, P Davis, SC Cho, BI Kim, M Dahl, N Tabatabaei |
Pediatric Research | 2000 |
Chronic Lung Disease in Early Infancy
D Riley |
Chronic Lung Disease in Early Infancy | 1999 |
Chronic Lung Disease in Early Infancy: Progression from Acute to Chronic Lung Disease
D Carlton |
Chronic Lung Disease in Early Infancy: Progression from Acute to Chronic Lung Disease | 1999 |
Perfluorocarbon-associated gas exchange improves oxygenation, lung mechanics, and survival in a model of adult respiratory distress syndrome:
MC Papo, PR Paczan, BP Fuhrman, DM Steinhorn, LJ Hernan, CL Leach, BA Holm, JE Fisher, BA Kahn |
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MB arsotti, V Chundu, S Silvka, J Sephus, M Hallman |
Lung | 1996 |
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G Miserocchi, BH Poskurica, M Fabbro, B Crisafulli |
Respiration Physiology | 1995 |
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MJ Balsan, JG Jones, RD Guthrie |
Pediatric Pulmonology | 1991 |
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RD Bland, DP Carlton, RG Scheerer, JJ Cummings, DL Chapman |
Journal of Clinical Investigation | 1989 |
The Severity of RDS during the First Two Neonatal Days in Relationship to Fluid Intake
M Hallman |
Acta Paediatrica | 1989 |
Relationship between Alveolar Saturated Phosphatidylcholine Pool Sizes and Compliance of Preterm Rabbit Lungs: The Effect of Maternal Corticosteroid Treatment
M Ikegami, AH Jobe, T Yamada, S Seidner |
American journal of respiratory and critical care medicine | 1989 |