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Research Article Free access | 10.1172/JCI112950

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

R Raghow, A E Postlethwaite, J Keski-Oja, H L Moses, and A H Kang

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Published April 1, 1987 - More info

Published in Volume 79, Issue 4 on April 1, 1987
J Clin Invest. 1987;79(4):1285–1288. https://doi.org/10.1172/JCI112950.
© 1987 The American Society for Clinical Investigation
Published April 1, 1987 - Version history
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Abstract

Transforming growth factor-beta (TGF beta), when injected subcutaneously into newborn mice, induces a rapid fibrotic response, stimulates chemotaxis, and elevates the rates of biosynthesis of collagen and fibronectin by fibroblasts in vitro. We explored the molecular mechanisms of TGF beta-mediated stimulation of collagen and fibronectin synthesis in cultured human foreskin fibroblasts. TGF beta preferentially stimulated the synthesis of fibronectin and type I procollagen chains 3-5-fold as shown by polypeptide analysis. Concomitant elevation in the steady state levels of messenger RNAs (mRNAs) coding for type I procollagen and fibronectin also occurred but without a net increase in the rate of transcription of either of these genes. The preferential stabilization of mRNAs specifying type I procollagen and fibronectin provides a partial explanation for the mechanisms by which TGF beta enhances the synthesis of type I procollagen and fibronectin in mesenchymal cells.

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Referenced in 1 patents
48 readers on Mendeley
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