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N K Fukagawa, … , D M Bier, V R Young
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2306-2311. https://doi.org/10.1172/JCI112240.
Citation Information: J Clin Invest. 1985;76(6):2306-2311. https://doi.org/10.1172/JCI112240.
Abstract
In vivo effects of insulin on plasma leucine and alanine kinetics were determined in healthy postabsorptive young men (n = 5) employing 360-min primed, constant infusions of L-[1-13C]leucine and L-[15N]alanine during separate single rate euglycemic insulin infusions. Serum insulin concentrations of 16.4 +/- 0.8, 29.1 +/- 2.7, 75.3 +/- 5.0, and 2,407 +/- 56 microU/ml were achieved. Changes in plasma 3-methyl-histidine (3-MeHis) were obtained as an independent qualitative indicator of insulin-mediated reduction in proteolysis. Hepatic glucose output was evaluated at the lowest insulin level using D-[6,6-2H2]glucose. The data demonstrate a dose-response effect of insulin to reduce leucine flux, from basal values of 77 +/- 1 to 70 +/- 2, 64 +/- 3, 57 +/- 3, and 52 +/- 4 mumol(kg X h)-1 at the 16, 29, 75, and 2,407 microU/ml insulin levels, respectively (P less than 0.01). A parallel, progressive reduction in 3-MeHis from 5.8 +/- 0.3 to 4.3 +/- 0.3 microM was revealed. Leucine oxidation estimated from the 13C-enrichment of expired CO2 and plasma leucine (12 +/- 1 mumol[kg X h]-1) and from the 13C-enrichment of CO2 and plasma alpha-ketoisocaproate (19 +/- 2 mumol[kg X h]-1) increased at the 16 microU/ml insulin level to 16 +/- 1 and 24 +/- 2 mumol(kg X h)-1, respectively (P less than 0.05 for each), but did not increase at higher insulin levels. Alanine flux (206 +/- 13 mumol(kg X h)-1) did not increase during the clamp, but alanine de novo synthesis increased in all studies from basal rates of 150 +/- 13 to 168 +/- 23, 185 +/- 21, 213 +/- 29, and 187 +/- 15 mumol(kg X h)-1 at 16, 29, 75, and 2,407 microU/ml insulin levels, respectively (P less than 0.05). These data indicate the presence of insulin-dependent suppression of leucine entry into the plasma compartment in man secondary to a reduction in proteolysis and the stimulation of alanine synthesis during euglycemic hyperinsulinemia.
Authors
N K Fukagawa, K L Minaker, J W Rowe, M N Goodman, D E Matthews, D M Bier, V R Young
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Epidural blockade improves substrate utilization after surgery
T Schricker, L Wykes, F Carli |
American journal of physiology. Endocrinology and metabolism | 2000 |
|
Effect of carbohydrate ingestion on ammonia metabolism during exercise in humans
RJ Snow, MF Carey, CG Stathis, MA Febbraio, M Hargreaves |
Journal of applied physiology | 2000 |
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Regulation of uterine and umbilical amino acid uptakes by maternal amino acid concentrations
PJ Thureen, SM Anderson, WW Hay |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2000 |
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Nitrogen Requirements of an Old World Nectarivore, the Orange‐Tufted Sunbird Nectarinia osea
L Roxburgh, B Pinshow |
Physiological and Biochemical Zoology | 2000 |
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Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism1
N Mauras, KO OBrien, S Welch, A Rini, K Helgeson, NE Vieira, AL Yergey |
The Journal of clinical endocrinology and metabolism | 2000 |
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Recombinant Human Insulin-Like Growth Factor I Has Significant Anabolic Effects in Adults with Growth Hormone Receptor Deficiency: Studies on Protein, Glucose, and Lipid Metabolism*
N Mauras, V Martinez, A Rini, J Guevara-Aguirre |
The Journal of clinical endocrinology and metabolism | 2000 |
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The mysteries of nitrogen balance
JC Waterlow |
Nutrition Research Reviews | 1999 |
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Role of nutrients in the regulation of in vivo protein metabolism in humans
D Darmaun |
Acta Paediatrica | 1999 |
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Inverse alterations of BCKA dehydrogenase activity in cardiac and skeletal muscles of diabetic rats
YB Lombardo, C Serdikoff, M Thamotharan, HS Paul, SA Adibi |
American journal of physiology. Endocrinology and metabolism | 1999 |
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Epinephrine Transiently Increases Amino Acid Disappearance to Lower Amino Acid Levels in Humans
KM Ratheiser, GR Pesola, RG Campbell, DE Matthews |
JPEN. Journal of parenteral and enteral nutrition | 1999 |
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Effects of hyper- and hypoosmolality on whole body protein and glucose kinetics in humans
K Berneis, R Ninnis, D Häussinger, U Keller |
American journal of physiology. Endocrinology and metabolism | 1999 |
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Sex-Steroid Interactions with Growth Hormone
JD Veldhuis, A Giustina |
1999 | |
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Effects of Insulin and Amino Acids on Glucose and Leucine Metabolism in CAPD Patients
P Castellino, LI Luzi, M Giordano, RA Defronzo |
Journal of the American Society of Nephrology : JASN | 1999 |
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The Role of Insulin and Other Hormones in the Regulation of Amino Acid and Protein Metabolism in Humans
WR Miers, EJ Barrett |
Journal of Basic and Clinical Physiology and Pharmacology | 1998 |
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Exogenous insulin reduces proteolysis and protein synthesis in extremely low birth weight infants
BB Poindexter, CA Karn, SC Denne |
The Journal of Pediatrics | 1998 |
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Protein metabolism in insulin-dependent diabetes mellitus
M Charlton, KS Nair |
The Journal of nutrition | 1998 |
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Extreme hyperinsulinemia unmasks insulin’s effect to stimulate protein synthesis in the human forearm
TA Hillier, DA Fryburg, LA Jahn, EJ Barrett |
American journal of physiology. Endocrinology and metabolism | 1998 |
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Parenteral Glutamine Infusion Alters Insulin-Mediated Glucose Metabolism
MJ Borel, PE Williams, K Jabbour, D Levenhagen, E Kaizer, PJ Flakoll |
JPEN. Journal of parenteral and enteral nutrition | 1998 |
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Principles of Perinatal—Neonatal Metabolism
RM Cowett |
1998 | |
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How Is Whole Body Protein Turnover Perturbed in Growth Hormone-Deficient Adults?1
DM Hoffman, R Pallasser, M Duncan, TV Nguyen, KK Ho |
The Journal of clinical endocrinology and metabolism | 1998 |
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Short-term effects of glucagon-like peptide 1 (7–36 amide) on leucine kinetics in healthy volunteers
A Shalev, U Keller |
Clinical Nutrition | 1997 |
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Pour un apport systématique d'insuline en nutrition parentérale chez les patients agressés
P Boulétreau |
Nutrition Clinique et Métabolisme | 1997 |
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Maintaining muscle protein anabolism after a metabolic stress: role of dextrose vs. amino acid availability
MJ Borel, PE Williams, K Jabbour, JC Hibbard, PJ Flakoll |
American journal of physiology. Endocrinology and metabolism | 1997 |
|
Amino acids suppress proteolysis independent of insulin throughout the neonatal period
BB Poindexter, CA Karn, JA Ahlrichs, J Wang, CA Leitch, EA Liechty, SC Denne |
American journal of physiology. Endocrinology and metabolism | 1997 |
|
Evidence for a catabolic role of glucagon during an amino acid load
MR Charlton, DB Adey, KS Nair |
Journal of Clinical Investigation | 1996 |
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Mechanisms of postprandial protein accretion in human skeletal muscle. Insight from leucine and phenylalanine forearm kinetics
P Tessari, M Zanetti, R Barazzoni, M Vettore, F Michielan |
Journal of Clinical Investigation | 1996 |
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GROWTH SUPPRESSION BY GLUCOCORTICOID THERAPY
DB Allen |
Endocrinology & Metabolism Clinics of North America | 1996 |
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Metabolic effects of recombinant human insulin-like growth factor-I in humans: comparison with recombinant human growth hormone
N Mauras, MW Haymond |
Pediatric Nephrology | 1996 |
|
Simultaneous measurement of albumin and fibrinogen synthetic rates in normal fasted subjects
DC Mcmillan, C Slater, T Preston, JS Falconer, KC Fearon |
Nutrition | 1996 |
|
L'usage de l'insuline comme agent anabolisant doit-il être préconisé chez le sujet dénutri ou agressé?
G Iapichino, D Radrizzani, A Noto, S Marzorati, G Pasetti, A Pezzi, G Zanforlih |
Nutrition Clinique et Métabolisme | 1996 |
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Protein degradation and synthesis measured with multiple amino acid tracers in vivo
P Tessari, R Barazzoni, M Zanetti, M Vettore, S Normand, D Bruttomesso, B Beaufrere |
American journal of physiology. Endocrinology and metabolism | 1996 |
|
Effect of glutamine on leucine metabolism in humans
RG Hankard, MW Haymond, D Darmaun |
American journal of physiology. Endocrinology and metabolism | 1996 |
|
Protein turnover during puberty in normal children
SA Arslanian, SC Kalhan |
American journal of physiology. Endocrinology and metabolism | 1996 |
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Influences of dietary energy and protein on leucine kinetics during feeding in healthy adults
NR Gibson, A Fereday, M Cox, D Halliday, PJ Pacy, DJ Millward |
American journal of physiology. Endocrinology and metabolism | 1996 |
|
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity
L Luzi, P Castellino, RA DeFronzo |
American journal of physiology. Endocrinology and metabolism | 1996 |
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Nitrogen and Energy Balance of the Fruit Bat Rousettus aegyptlacus on Natural Fruit Diets
C Korine, Z Arad, A Arieli |
Physiological and Biochemical Zoology | 1996 |
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Digestion, Absorption, and Fermentation of Carbohydrates in the Newborn
CL Kien |
Clinics in Perinatology | 1996 |
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Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
DA Fryburg, LA Jahn, SA Hill, DM Oliveras, EJ Barrett |
Journal of Clinical Investigation | 1995 |
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Glutamate-arginine salts and hormonal responses to exercise
B Eto, GÈ Mod, D Porquet, G Peres |
Archives Of Physiology And Biochemistry | 1995 |
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Insulin regulation of muscle glucose metabolism: Role of pre-receptorial mechanisms
B Capaldo, L Saccà |
Diabetes / Metabolism Reviews | 1995 |
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Energy Expenditure in Type 2 Diabetic Patients on Metformin and Sulphonylurea Therapy
PK Chong, RT Jung, MJ Rennie, CM Scrimgeour |
Diabetic Medicine | 1995 |
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Low-Dose Oral Glyburide Reduces Fasting Blood Glucose by Decreasing Hepatic Glucose Production in Healthy Volunteers Without Increasing Carbohydrate Oxidation
JA Tayek |
The American Journal of the Medical Sciences | 1995 |
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Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF
D Reaich, KA Graham, SM Channon, C Hetherington, CM Scrimgeour, R Wilkinson, TH Goodship |
American journal of physiology. Endocrinology and metabolism | 1995 |
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Effect of intravenous glucose and lipid on proteolysis and glucose production in normal newborns
SC Denne, CA Karn, J Wang, EA Liechty |
American journal of physiology. Endocrinology and metabolism | 1995 |
|
Effects of epinephrine on human muscle glucose and protein metabolism
DA Fryburg, RA Gelfand, LA Jahn, D Oliveras, RS Sherwin, L Sacca, EJ Barrett |
American journal of physiology. Endocrinology and metabolism | 1995 |
|
Effect of cortisol on energy expenditure and amino acid metabolism in humans
DJ Brillon, B Zheng, RG Campbell, DE Matthews |
American journal of physiology. Endocrinology and metabolism | 1995 |
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Nutritional Management and the Multisystem Organ Failure/systemic Inflammatory Response Syndrome in Critically Ill Preterm Neonates
D Adan, EF Gamma, LE Browne |
Critical Care Clinics | 1995 |
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Hyperinsulinemia Inhibits Myocardial Protein Degradation in Patients With Cardiovascular Disease and Insulin Resistance
PH McNulty, RJ Louard, LI Deckelbaum, BL Zaret, LH Young |
Circulation | 1995 |
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Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults
SD Boulware, WV Tamborlane, NJ Rennert, N Gesundheit, RS Sherwin |
Journal of Clinical Investigation | 1994 |
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Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans
MA Hussain, O Schmitz, A Mengel, Y Glatz, JS Christiansen, J Zapf, ER Froesch |
Journal of Clinical Investigation | 1994 |
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Effects of insulin on whole-body and regional amino acid metabolism
P Tessari |
Diabetes/Metabolism Reviews | 1994 |
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The separate and combined effect of leucine and insulin on muscle free amino acids
P Essén, SD Heys, P Garlicky, J Wernerman |
Clinical Physiology | 1994 |
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Adaptive responses to very low protein diets: The first comparison of ketoacids to essential amino acids
T Masud, VR Young, T Chapman, BJ Maroni |
Kidney International | 1994 |
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Decreased protein catabolism after exercise in subjects with IDDM
JT Devlin, A Scrimgeour, I Brodsky, S Fuller |
Diabetologia | 1994 |
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Effects of insulin-like growth factor-I (IGF-I), insulin and combined IGF-I-insulin infusions on protein metabolism in dogs
AM Umpleby, F Shojaee-Moradie, MJ Thomason, JM Kelly, A Skottner, PH Sonksen, R Jones |
European Journal of Clinical Investigation | 1994 |
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Leucine kinetics during a brief fast in diabetes in pregnancy
SC Kalhan, SC Denne, DM Patel, IF Nuamah, SM Savin |
Metabolism | 1994 |
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The opposing effects of insulin and hyperglycemia in modulating amino acid metabolism during a glucose tolerance test in lean and obese subjects
DE Rice, PJ Flakoll, MM May, JO Hill, NN Abumrad |
Metabolism | 1994 |
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Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism
DH Wasserman, PA Ruzumna, DP Bracy, DB Lacy, HW Boothe, PE Williams, NN Abumrad |
Metabolism | 1994 |
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Hepatic amino acid metabolism during hyperinsulinemia and hyperaminoacidemia in conscious rabbit during late pregnancy
MC Pere, A Baudelin, K Briggs, C Teng, M Gilbert |
Metabolism | 1994 |
|
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women
S Welle, M Statt, R Barnard, J Amatruda |
Metabolism | 1994 |
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Anabolic Effects of Insulin and Amino Acids in Promoting Nitrogen Accretion in Postoperative Patients
R Valarini, MF Sousa, R Kalil, NN Abumrad, MC Riella |
JPEN. Journal of parenteral and enteral nutrition | 1994 |
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Response of protein synthesis in human skeletal muscle to insulin: an investigation with L-[2H5]phenylalanine
MA McNurlan, P Essen, A Thorell, AG Calder, SE Anderson, O Ljungqvist, A Sandgren, I Grant, I Tjader, PE Ballmer, et |
American journal of physiology. Endocrinology and metabolism | 1994 |
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Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
S Caprio, G Cline, S Boulware, C Permanente, GI Shulman, RS Sherwin, WV Tamborlane |
American journal of physiology. Endocrinology and metabolism | 1994 |
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Chloroquine reduces whole body proteolysis in humans
PD Feo, E Volpi, P Lucidi, G Cruciani, F Santeusanio, GB Bolli, P Brunetti |
American journal of physiology. Endocrinology and metabolism | 1994 |
|
Up-regulation of liver system A for neutral amino acid transport in euglycemic hyperinsulinemic rats
A Ferrer-Martínez, J Casado, A Leturque, A Felipe, M Pastor-Anglada |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1994 |
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Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously
SR Kupfer, LE Underwood, RC Baxter, DR Clemmons |
Journal of Clinical Investigation | 1993 |
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Effect of insulin on system A amino acid transport in human skeletal muscle
RC Bonadonna, MP Saccomani, C Cobelli, RA DeFronzo |
Journal of Clinical Investigation | 1993 |
|
Intravenous glucose suppresses glucose production but not proteolysis in extremely premature newborns
DE Hertz, CA Karn, YM Liu, EA Liechty, SC Denne |
Journal of Clinical Investigation | 1993 |
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IGFs: function and clinical importance 6 Therapy with recombinant human insulin-like growth factor I in children with insensitivity to growth hormone and in catabolic conditions
LO Underwood, P Backeljauw |
Journal of Internal Medicine | 1993 |
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Differential Metabolic Actions of Biosynthetic Insulin Analogues in Normal Man Assessed by Stable Isotopic Tracers
SV Gelding, N Coldham, V Anyaoku, K Heslop, D Halliday, DG Johnston |
Diabetic Medicine | 1993 |
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Insulin action on protein metabolism
G Biolo, RR Wolfe |
Baillière's Clinical Endocrinology and Metabolism | 1993 |
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Les modulateurs hormonaux du métabolisme protéique. Aspects thérapeutiques
P Boulétreau, C Chambrier |
Nutrition Clinique et Métabolisme | 1993 |
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Leucine and phenylalanine kinetics in compensated liver cirrhosis: Effects of insulin
P Tessari, G Biolo, S Inchiostro, R Orlando, M Vettore, G Sergi |
Gastroenterology | 1993 |
|
Acute hyperglycemia enhances proteolysis in normal man
PJ Flakoll, JO Hill, NN Abumrad |
American journal of physiology. Endocrinology and metabolism | 1993 |
|
Effects of exercise and weight loss on leucine turnover in different types of obesity
JA Kanaley, MW Haymond, MD Jensen |
American journal of physiology. Endocrinology and metabolism | 1993 |
|
Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion
PH McNulty, LH Young, EJ Barrett |
American journal of physiology. Endocrinology and metabolism | 1993 |
|
Growth Hormone and Somatomedins during Lifespan
EE Müller, D Cocchi, V Locatelli |
1993 | |
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Yearbook of Intensive Care and Emergency Medicine 1993
JL Vincent |
1993 | |
|
Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle
RJ Louard, DA Fryburg, RA Gelfand, EJ Barrett |
Journal of Clinical Investigation | 1992 |
|
Effect of insulin in conjunction with glucose, amino acids and potassium on net metabolism of glucose and amino acids in the goat mammary gland
S Tesseraud, J Grizard, B Makarski, E Debras, G Bayle, C Champredon |
Journal of Dairy Research | 1992 |
|
Increased protein turnover in obese women
S Welle, RR Barnard, M Statt, JM Amatruda |
Metabolism | 1992 |
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Modern Methods in Protein Nutrition and Metabolism
MW Manatt, PA Garcia |
Modern Methods in Protein Nutrition and Metabolism | 1992 |
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Meal stimulation of albumin synthesis: a significant contributor to whole body protein synthesis in humans
PD Feo, FF Horber, MW Haymond |
American journal of physiology. Endocrinology and metabolism | 1992 |
|
Effects of insulin and amino acid infusion on leucine and phenylalanine kinetics in type 1 diabetes
S Inchiostro, G Biolo, D Bruttomesso, C Fongher, L Sabadin, M Carlini, E Duner, A Tiengo, P Tessari |
American journal of physiology. Endocrinology and metabolism | 1992 |
|
Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
KS Nair, RG Schwartz, S Welle |
American journal of physiology. Endocrinology and metabolism | 1992 |
|
Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart
LH Young, DM Dahl, D Rauner, EJ Barrett |
Circulation research | 1992 |
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Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man
P Tessari, S Inchiostro, G Biolo, E Vincenti, L Sabadin |
Journal of Clinical Investigation | 1991 |
|
Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans
PD Feo, MG Gaisano, MW Haymond |
Journal of Clinical Investigation | 1991 |
|
Protein Anabolic Actions of Insulin in the Human Body
WM Bennet, MJ Rennie |
Diabetic Medicine | 1991 |
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Nutrient interactions with reference to amino acid and protein metabolism in non-ruminants; particular emphasis on protein-energy relations in man
VR Young |
Zeitschrift für Ernährungswissenschaft | 1991 |
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Insulin time-dependent effects on the leg exchange of glucose and amino acids in man
F Lundgren, E Edén, B Arfvidsson, K Lundholm |
European Journal of Clinical Investigation | 1991 |
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Influence of low- and high-protein diets on insulin and insulin-like growth factor-1 binding to skeletal muscle and liver in the growing rat
D Dardevet, M Manin, M Balage, C Sornet, J Grizard |
British Journal of Nutrition | 1991 |
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Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis
AS Petrides, L Luzi, A Reuben, C Riely, RA Defronzo |
Hepatology | 1991 |
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Differential effects of insulin resistance on leucine and glucose kinetics in obesity
B Caballero, RJ Wurtman |
Metabolism | 1991 |
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Impaired insulin mediated potassium uptake in adolescents with IDDM
S Arslanian, A Austin |
Biochemical Medicine and Metabolic Biology | 1991 |
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New Techniques in Nutritional Research
JR Turnlund |
New Techniques in Nutritional Research | 1991 |
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Effect of systemic hyperinsulinemia on amino acid flux across human legs in postabsorptive state
B Arfvidsson, H Zachrisson, AC Moller-Loswick, A Hyltander, R Sandstrom, K Lundholm |
American journal of physiology. Endocrinology and metabolism | 1991 |
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Interaction of exercise and insulin action in humans
DH Wasserman, RJ Geer, DE Rice, D Bracy, PJ Flakoll, LL Brown, JO Hill, NN Abumrad |
American journal of physiology. Endocrinology and metabolism | 1991 |
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Compartmental model of leucine kinetics in humans
C Cobelli, MP Saccomani, P Tessari, G Biolo, L Luzi, DE Matthews |
American journal of physiology. Endocrinology and metabolism | 1991 |
|
Glutamine nitrogen kinetics in insulin-dependent diabetic humans
D Darmaun, M Rongier, J Koziet, JJ Robert |
American journal of physiology. Endocrinology and metabolism | 1991 |
|
Isolated hypoisoleucinemia impairs whole body but not hepatic protein synthesis in humans
L Lecavalier, PD Feo, MW Haymond |
American journal of physiology. Endocrinology and metabolism | 1991 |
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Principles of Perinatal-Neonatal Metabolism
RM Cowett |
1991 | |
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Chest pain in the accident and emergency department
P Kinnersley, P Owen, C Wilkinson |
BMJ : British Medical Journal | 1991 |
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Cardiac cachexia
PH Sonksen, F Salomon, R Cuneo, M Umpleby, S Bowes |
BMJ : British Medical Journal | 1991 |
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Vitamins and IQ
J Yudkin |
BMJ : British Medical Journal | 1991 |
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Human growth hormone prevents the protein catabolic side effects of prednisone in humans
FF Horber, MW Haymond |
Journal of Clinical Investigation | 1990 |
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Nutritional status affects renal 3-methylhistidine handling in humans
LJ Hoffer |
Metabolism | 1990 |
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Mechanism of muscle wasting in myotonic dystrophy
RC Griggs, R Jozefowicz, W Kingston, KS Nair, BE Herr, D Halliday |
Annals of Neurology | 1990 |
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Influence of glucagon on protein and leucine metabolism: A study in fasting man with induced insuiin resistance
PJ Pacy, KN Cheng, GC Ford, D Halliday |
British Journal of Surgery | 1990 |
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Effects of insulin, biguanide antihyperglycaemic agents and beta-adrenergic agonists on pathways of myocardial proteolysis
DP Thorne, TD Lockwood |
Biochemical Journal | 1990 |
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Dissociation of the effects of epinephrine and insulin on glucose and protein metabolism
P Castellino, L Luzi, SD Prato, RA DeFronzo |
American journal of physiology. Endocrinology and metabolism | 1990 |
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Role of glucagon in disposal of an amino acid load
G Boden, L Tappy, F Jadali, RD Hoeldtke, I Rezvani, OE Owen |
American journal of physiology. Endocrinology and metabolism | 1990 |
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Hormonal Regulation of Protein Metabolism
CL Long, SF Lowry |
JPEN. Journal of parenteral and enteral nutrition | 1990 |
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Protein Metabolism Assessed by 1-13C Leucine Infusions in Patients Undergoing Bone Marrow Transplantation
U Keller, ME Kraenzlin, A Gratwohl, A Thélin, E Straumann, MJ Arnaud, B Speck, W Stauffacher |
JPEN. Journal of parenteral and enteral nutrition | 1990 |
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Measurement of myocardial glycogen synthesis in diabetic and fasted rats
MR Laughlin, WA Petit, RG Shulman, EJ Barrett |
American journal of physiology. Endocrinology and metabolism | 1990 |
|
Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. Comparison with insulin
R Jacob, E Barrett, G Plewe, KD Fagin, RS Sherwin |
Journal of Clinical Investigation | 1989 |
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Effects of branched-chain amino acids on protein turnover
ME May, MG Buse |
Diabetes / Metabolism Reviews | 1989 |
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The in vivo study of cardiac and skeletal muscle protein turnover
EJ Barrett, RA Gelfand |
Diabetes / Metabolism Reviews | 1989 |
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Influence of nutrient intake on protein turnover
MA McNurlan, PJ Garlick |
Diabetes / Metabolism Reviews | 1989 |
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Participation of ornithine aminotransferase in the synthesis and catabolism of ornithine in mice. Studies using gabaculine and arginine deprivation
E Alonso, V Rubio |
Biochemical Journal | 1989 |
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Métabolisme azoté chez le sujet sain
L Cynober, C Coudray-Lucas, F Ziegler, JP Bandt, F Blondé-Cynober, F Plassart, SK Lim, J Giboudeau |
Nutrition Clinique et Métabolisme | 1989 |
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Advances in Hospital Nutrition
BR Bistrian, T Jaksic |
Journal of the American College of Nutrition | 1989 |
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Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans
B Beaufrere, FF Horber, WF Schwenk, HM Marsh, D Matthews, JE Gerich, MW Haymond |
American journal of physiology. Endocrinology and metabolism | 1989 |
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Amino acids augment insulin's suppression of whole body proteolysis
PJ Flakoll, M Kulaylat, M Frexes-Steed, H Hourani, LL Brown, JO Hill, NN Abumrad |
American journal of physiology. Endocrinology and metabolism | 1989 |
|
Stimulation of protein turnover by carbohydrate overfeeding in men
S Welle, DE Matthews, RG Campbell, KS Nair |
American journal of physiology. Endocrinology and metabolism | 1989 |
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Energy expenditure in children with type I diabetes: evidence for increased thermogenesis
MJ Muller, A von zur Muhlen, HU Lautz, FW Schmidt, M Daiber, P Hurter |
BMJ : British Medical Journal | 1989 |
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Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans
KS Nair, SL Welle, D Halliday, RG Campbell |
Journal of Clinical Investigation | 1988 |
|
Glucose and amino acid metabolism in aging man: Differential effects of insulin
NK Fukagawa, KL Minaker, JW Rowe, DE Matthews, DM Bier, VR Young |
Metabolism | 1988 |
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Insulin inhibits protein degradation in skeletal muscles of eviscerated fasted rats
OL Smith |
Metabolism | 1988 |
|
Dynamics of the protein metabolic response to burn injury
F Jahoor, M Desai, DN Herndon, RR Wolfe |
Metabolism | 1988 |
|
Preservation of insulin effects on glucose production and proteolysis during fasting
MD Jensen, JM Miles, JE Gerich, PE Cryer, MW Haymond |
American journal of physiology. Endocrinology and metabolism | 1988 |
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Effects of diabetes and starvation on skeletal muscle branched-chain alpha-keto acid dehydrogenase activity
RP Aftring, WJ Miller, MG Buse |
American journal of physiology. Endocrinology and metabolism | 1988 |
|
Effects of Parenteral Lipid on Leucine Metabolism: Dependence of Fatty Acid Chain Length
MW Haymond, P Tessari, B Beaufrere, N Rodriguez, J Bailey, JM Miles |
JPEN. Journal of parenteral and enteral nutrition | 1988 |
|
Insulin responsiveness of protein metabolism in vivo following bedrest in humans
RE Shangraw, CA Stuart, MJ Prince, EJ Peters, RR Wolfe |
American journal of physiology. Endocrinology and metabolism | 1988 |
|
Leucine incorporation into mixed skeletal muscle protein in humans
KS Nair, D Halliday, RC Griggs |
American journal of physiology. Endocrinology and metabolism | 1988 |
|
Praxis der parenteralen und enteralen Ernährung in der Chirurgie
M Heberer, B Günther |
1988 | |
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Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition
P Tessari, S Inchiostro, G Biolo, R Trevisan, G Fantin, MC Marescotti, E Iori, A Tiengo, G Crepaldi |
Journal of Clinical Investigation | 1987 |
|
Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man
RA Gelfand, EJ Barrett |
Journal of Clinical Investigation | 1987 |
|
Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis
P Castellino, L Luzi, DC Simonson, M Haymond, RA DeFronzo |
Journal of Clinical Investigation | 1987 |
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Effect of insulin on hind-limb and whole-body leucine and protein metabolism in fed and fasted lambs
VH Oddy, DB Lindsay, PJ Barker, AJ Northrop |
British Journal of Nutrition | 1987 |
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Insulin Resistance and Ammo Acid Metabolism in Obesity
B Caballero |
Annals of the New York Academy of Sciences | 1987 |
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3 The use of stable isotopes in metabolic investigation
DM Bier |
Baillière's Clinical Endocrinology and Metabolism | 1987 |
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Plasma tryptophan and total neutral amino acid levels in men: Influence of hyperinsulinemia and age
NK Fukagawa, KL Minaker, JW Rowe, VR Young |
Metabolism | 1987 |
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Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients
KS Nair, GC Ford, D Halliday |
Metabolism | 1987 |
|
Plasma proline kinetics and the regulation of proline synthesis in man
T Jaksic, DA Wagner, JF Burke, VR Young |
Metabolism | 1987 |
|
Dose-response curves of effects of insulin on leucine kinetics in humans
P Tessari, R Trevisan, S Inchiostro, G Biolo, R Nosadini, SV de Kreutzenberg, E Duner, A Tiengo, G Crepaldi |
American journal of physiology. Endocrinology and metabolism | 1986 |
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Replacement of Renal Function by Dialysis
W Drukker, FM Parsons, JF Maher |
1979 |
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