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Research Article Free access | 10.1172/JCI112195

Polymorphism of the complement receptor for C3bi.

G R Russ, A P Haddad, B D Tait, and A J d'Apice

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Published November 1, 1985 - More info

Published in Volume 76, Issue 5 on November 1, 1985
J Clin Invest. 1985;76(5):1965–1970. https://doi.org/10.1172/JCI112195.
© 1985 The American Society for Clinical Investigation
Published November 1, 1985 - Version history
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Abstract

RM2.184, a mouse IgG2a monoclonal antibody, recognizes a polymorphic determinant on the complement receptor for C3bi which is present on granulocytes and monocytes. The RM2.184 epitope is distinct from the monomorphic determinant recognized by the monoclonal antibody OKM1. The RM2.184 epitope is probably on the alpha subunit and dependent on the association of the alpha and beta subunits for its configuration, as it can not be detected after the subunits have been dissociated. The phenotypic frequency of the RM2.184 antigen is approximately 14%, and its segregation in families is independent of HLA and consistent with an autosomal co-dominant mode of inheritance.

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