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Research Article Free access | 10.1172/JCI111185

Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

G Gabbiani, O Kocher, W S Bloom, J Vandekerckhove, and K Weber

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Published January 1, 1984 - More info

Published in Volume 73, Issue 1 on January 1, 1984
J Clin Invest. 1984;73(1):148–152. https://doi.org/10.1172/JCI111185.
© 1984 The American Society for Clinical Investigation
Published January 1, 1984 - Version history
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Abstract

Actin of smooth muscle cells of rat and human aortic media shows a predominance of the alpha-isoform. In experimental rat aortic intimal thickening, in human atheromatous plaque, and in cultured aortic smooth muscle cells, there is a typical switch in actin expression with a predominance of the beta-form and a noticeable amount of gamma-form. This pattern of actin expression represents a new reliable protein-chemical marker of experimental and human atheromatous smooth muscle cells.

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