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Citations to this article

Mechanisms of Insulin Resistance in Aging
Raymond I. Fink, … , Jennifer Griffin, Jerrold M. Olefsky
Raymond I. Fink, … , Jennifer Griffin, Jerrold M. Olefsky
Published June 1, 1983
Citation Information: J Clin Invest. 1983;71(6):1523-1535. https://doi.org/10.1172/JCI110908.
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Research Article Article has an altmetric score of 12

Mechanisms of Insulin Resistance in Aging

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Abstract

We have studied 17 elderly and 27 non-elderly, nonobese subjects (mean age 69±1 and 37±2 yr, respectively) to assess the mechanisms responsible for the abnormal carbohydrate tolerance associated with aging. Serum glucose and insulin levels were significantly elevated in the elderly subjects compared with the nonelderly subjects during a 75-g oral glucose tolerance test, suggesting an insulin resistant state. Peripheral insulin sensitivity was assessed in both groups using the euglycemic glucose clamp technique during an insulin infusion rate of 40 mU/m2 per min. Similar steady-state serum insulin levels led to a peripheral glucose disposal rate of 151±17 mg/m2 per min in the elderly compared with a value of 247±12 mg/m2 per min in the nonelderly, thus documenting the presence of insulin resistance in the elderly subjects. Insulin binding to isolated adipocytes and monocytes was similar in the elderly and nonelderly groups (2.34±0.33 vs. 2.62±0.24% and 5.04±1.10 vs. 5.12±1.07%), respectively. Thus, insulin resistance in the presence of normal insulin binding suggests the presence of a postreceptor defect in insulin action. This was confirmed by performing additional euglycemic clamp studies using infusion rates of 15 and 1,200 mU/m2 per min to assess the contours of the dose-response relationship. These studies revealed a 39 and 25% decrease in the glucose disposal rate in the elderly subjects, respectively. The results confirm the presence of a postreceptor defect as well as a rightward shift in the dose-response curve. Insulin's ability to suppress hepatic glucose output was less in the elderly subjects during the 15 mU/m2 per min insulin infusion (77±5 vs. 89±4% suppression), but hepatic glucose output was fully and equally suppressed in both groups during the 40 and 1,200 mU/m2 per min infusion. Finally, a significant inverse relationship was observed between the degree of glucose intolerance in the individual elderly subjects, as reflected by the 2-h serum glucose level during the oral glucose tolerance test, and the degree of peripheral insulin resistance as assessed by the glucose disposal rate during the 40 mU/m2 per min insulin infusion (r = 0.59, P < 0.01).

Authors

Raymond I. Fink, Orville G. Kolterman, Jennifer Griffin, Jerrold M. Olefsky

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1957 Total
Citations: 2 6 4 7 12 16 18 15 13 10 10 12 11 9 12 32 9 8 7 10 11 4 9 5 9 8 9 9 12 8 8 11 11 12 6 16 8 11 9 13 7 4 1 424
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2005 (11)

Title and authors Publication Year
Comparison of nonspecific indications and quantitative methods for the assessment of insulin resistance in horses and ponies
DS Kronfeld, KH Treiber, RJ Geor
Journal of the American Veterinary Medical Association 2005
Gender-dependent effect of ageing on peripheral insulin action
AM Borissova, T Tankova, G Kirilov, D Koev
International Journal of Clinical Practice 2005
Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: The Fungata Study
W Kameda, M Daimon, T Oizumi, Y Jimbu, M Kimura, A Hirata, H Yamaguchi, H Ohnuma, M Igarashi, M Tominaga, T Kato
Metabolism 2005
Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
AJ Scheen
Diabetes & Metabolism 2005
Mechanisms of Hypoandrogenemia in Healthy Aging Men
PY Liu, A Iranmanesh, AX Nehra, DM Keenan, JD Veldhuis
Endocrinology and metabolism clinics of North America 2005
Handbook of the Biology of Aging
PM Wise
Handbook of the Biology of Aging 2005
Increased Susceptibility to Insulin Resistance Associated with Abdominal Obesity in Aging Rats **
KJ Catalano, RN Bergman, M Ader
Obesity research 2005
Cardiovascular risk in aging and obesity: Is there a role for GH?
M Gola, S Bonadonna, M Doga, G Mazziotti, A Giustina
Journal of Endocrinological Investigation 2005
Comparative study on the preventing effects of oral vanadyl sulfate and dietary restriction on the age-related glucose intolerance in rats
M Novelli, V Tata, V Fierabracci, M Barbera, R Rossetti, P Masiello
Aging clinical and experimental research 2005
Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow
MR Skilton, NT Lai, KA Griffiths, LM Molyneaux, DK Yue, DR Sullivan, DS Celermajer
American journal of physiology. Heart and circulatory physiology 2005
Biological Basis of Geriatric Oncology
L Balducci, M Extermann
2005

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