We have studied 17 elderly and 27 non-elderly, nonobese subjects (mean age 69±1 and 37±2 yr, respectively) to assess the mechanisms responsible for the abnormal carbohydrate tolerance associated with aging. Serum glucose and insulin levels were significantly elevated in the elderly subjects compared with the nonelderly subjects during a 75-g oral glucose tolerance test, suggesting an insulin resistant state. Peripheral insulin sensitivity was assessed in both groups using the euglycemic glucose clamp technique during an insulin infusion rate of 40 mU/m2 per min. Similar steady-state serum insulin levels led to a peripheral glucose disposal rate of 151±17 mg/m2 per min in the elderly compared with a value of 247±12 mg/m2 per min in the nonelderly, thus documenting the presence of insulin resistance in the elderly subjects. Insulin binding to isolated adipocytes and monocytes was similar in the elderly and nonelderly groups (2.34±0.33 vs. 2.62±0.24% and 5.04±1.10 vs. 5.12±1.07%), respectively. Thus, insulin resistance in the presence of normal insulin binding suggests the presence of a postreceptor defect in insulin action. This was confirmed by performing additional euglycemic clamp studies using infusion rates of 15 and 1,200 mU/m2 per min to assess the contours of the dose-response relationship. These studies revealed a 39 and 25% decrease in the glucose disposal rate in the elderly subjects, respectively. The results confirm the presence of a postreceptor defect as well as a rightward shift in the dose-response curve. Insulin's ability to suppress hepatic glucose output was less in the elderly subjects during the 15 mU/m2 per min insulin infusion (77±5 vs. 89±4% suppression), but hepatic glucose output was fully and equally suppressed in both groups during the 40 and 1,200 mU/m2 per min infusion. Finally, a significant inverse relationship was observed between the degree of glucose intolerance in the individual elderly subjects, as reflected by the 2-h serum glucose level during the oral glucose tolerance test, and the degree of peripheral insulin resistance as assessed by the glucose disposal rate during the 40 mU/m2 per min insulin infusion (r = 0.59, P < 0.01).
Raymond I. Fink, Orville G. Kolterman, Jennifer Griffin, Jerrold M. Olefsky
Year: | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1957 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 2 | 6 | 4 | 7 | 12 | 16 | 18 | 15 | 13 | 10 | 10 | 12 | 11 | 9 | 12 | 32 | 9 | 8 | 7 | 10 | 11 | 4 | 9 | 5 | 9 | 8 | 9 | 9 | 12 | 8 | 8 | 11 | 11 | 12 | 6 | 16 | 8 | 11 | 9 | 13 | 7 | 4 | 1 | 424 |
Title and authors | Publication | Year |
---|---|---|
Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
ME Li, HP Lauritzen, BT ONeill, CH Wang, W Cai, BB Brandao, M Sakaguchi, R Tao, MF Hirshman, S Softic, CR Kahn |
Nature Communications | 2019 |
Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection
E Bowman, NT Funderburg |
Current HIV/AIDS Reports | 2019 |
Age-related changes in B cell metabolism
RK Kurupati, LH Haut, KE Schmader, HC Ertl |
Aging | 2019 |
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
EL Watts, A PerezCornago, PN Appleby, D Albanes, E Ardanaz, A Black, HB BuenodeMesquita, JM Chan, C Chen, SA Chubb, MB Cook, M Deschasaux, JL Donovan, DR English, L Flicker, ND Freedman, P Galan, GG Giles, EL Giovannucci, MJ Gunter, LA Habel, C Häggström, C Haiman, FC Hamdy, S Hercberg, JM Holly, J Huang, WY Huang, M Johansson, R Kaaks, T Kubo, JA Lane, TM Layne, LL Marchand, RM Martin, EJ Metter, K Mikami, RL Milne, HA Morris, LA Mucci, DE Neal, ML Neuhouser, SE Oliver, K Overvad, K Ozasa, V Pala, CH Pernar, M Pollak, MA Rowlands, CA Schaefer, JM Schenk, P Stattin, A Tamakoshi, E Thysell, M Touvier, A Trichopoulou, KK Tsilidis, SK Eeden, SJ Weinstein, L Wilkens, BB Yeap, TJ Key, NE Allen, RC Travis |
International Journal of Cancer | 2019 |
Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism
I González-Mariscal, RA Montoro, JF OConnell, Y Kim, M Gonzalez-Freire, QR Liu, I Alfaras, OD Carlson, E Lehrmann, Y Zhang, KG Becker, S Hardivillé, P Ghosh, JM Egan |
The FASEB Journal | 2019 |
High Prevalence of Diabetes Mellitus in a Cohort of Patients with Chronic Obstructive Pulmonary Disease in Trinidad, West Indies
K Rambaran, B Bhagan, A Ali, F Ali, S Toolsie, R Lobin, S Beharry, S Ghany, S Mohammed, G Davis, S Sakhamuri, S Teelucksingh, T Seemungal |
2019 | |
The clinical impact and biological mechanisms of skeletal muscle aging
Z Aversa, X Zhang, RA Fielding, I Lanza, NK LeBrasseur |
Bone | 2019 |
Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study
RH Chen, HY Chen, KM Man, SJ Chen, W Chen, PL Liu, YH Chen, WC Chen |
Medicine | 2019 |
An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery
PT Reidy, NM Yonemura, JH Madsen, AI McKenzie, ZS Mahmassani, MT Rondina, YK Lin, K Kaput, MJ Drummond |
Acta physiologica (Oxford, England) | 2019 |
Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults
LA Consitt, C Dudley, G Saxena |
Nutrients | 2019 |
Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging
JR Pérez-Estrada, D Hernández-García, F Leyva-Castro, J Ramos-León, CB Osiris, M Díaz-Muñoz, S Castro-Obregón, R Ramírez-Solís, C García, L Covarrubias |
Free radical biology & medicine | 2019 |
Reflecting on Concepts Relevant to Contemplating the Relationships Between Glucose–Insulin Perturbations, Nutrition, and Aging
HG Preuss, N Mrvichin, GR Kaats, D Bagchi, D Clouatre |
Journal of the American College of Nutrition | 2019 |
Omega-3 PUFA metabolism and brain modifications during aging
L Chevalier, H Chappus-McCendie, C Roberge, M Plourde |
Progress in neuro-psychopharmacology & biological psychiatry | 2019 |
Healthy Aging: A Complete Guide to Clinical Management
PP Coll |
2019 | |
Association between benign prostate enlargement-related storage and voiding symptoms and systolic blood pressure: a single-center cross-sectional study
EO Güven, I Selvi, E Karaismailoğlu |
Sao Paulo Medical Journal | 2019 |
Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration
J Zivanovic, E Kouroussis, JB Kohl, B Adhikari, B Bursac, S Schott-Roux, D Petrovic, JL Miljkovic, D Thomas-Lopez, Y Jung, M Miler, S Mitchell, V Milosevic, JE Gomes, M Benhar, B Gonzalez-Zorn, I Ivanovic-Burmazovic, R Torregrossa, JR Mitchell, M Whiteman, G Schwarz, SH Snyder, BD Paul, KS Carroll, MR Filipovic |
Cell Metabolism | 2019 |
Effects of 10-Week Treadmill Exercise on the Improvement of Obesity-Induced Autophagy Dysregulation in Arterial Endothelial Cells of Mice
JS Kim, TB Jeon, KW Baek, JI Yoo, SH An, HY Moon |
Exercise Science | 2019 |
An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery.
Reidy PT, Yonemura NM, Madsen JH, McKenzie AI, Mahmassani ZS, Rondina MT, Lin YK, Kaput K, Drummond MJ |
Acta physiologica (Oxford, England) | 2019 |