Citations to this article

Evidence for Two Pathways of Iodothyronine 5′-Deiodination in Rat Pituitary That Differ in Kinetics, Propylthiouracil Sensitivity, and Response to Hypothyroidism
Theo J. Visser, … , Jack L. Leonard, P. Reed Larsen
Theo J. Visser, … , Jack L. Leonard, P. Reed Larsen
Published April 1, 1983
Citation Information: J Clin Invest. 1983;71(4):992-1002. https://doi.org/10.1172/JCI110854.
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Research Article

Evidence for Two Pathways of Iodothyronine 5′-Deiodination in Rat Pituitary That Differ in Kinetics, Propylthiouracil Sensitivity, and Response to Hypothyroidism

Abstract

We have studied 5′-deiodination of thyroxine (T4) and 3,3′,5′-triiodothyronine (rT3) in rat pituitary tissue in vitro, with respect to substrate specificity, reaction kinetics, effects of 6-n-propyl-2-thiouracil (PTU), and the time course of effects of thyroid hormone depletion and repletion. Removal of one phenolic iodine or both tyrosyl iodines from the T4 molecule resulted in compounds that were not deiodinated, but alterations in the alanine side chain had little effect.

Authors

Theo J. Visser, Michael M. Kaplan, Jack L. Leonard, P. Reed Larsen

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Citations to this article (110)

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3 The iodothyronine deiodinases and 5′-deiodination
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5′ Deiodinase activity in brain regions of adult rats: Modifications in different situations of experimental hypothyroidism
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4 The molecular mechanisms of thyroid hormone action
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JE Silva 		Baillière's Clinical Endocrinology and Metabolism 1988
THYROXINE 5’-DEIODINATION BY A RAT MAMMARY ADENOCARCINOMA CELL LINE
ML Ong, AC Wong, A Malkin 		Biomedical Research 1988
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A Donda, MJ Reymond, MG Zürich, T Lemarchand-Béraud 		Molecular and Cellular Endocrinology 1987
Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat
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Iodothyronine 5′-deiodinase activity in rat brown adipose tissue during development
R Iglesias, JA Fernandez, T Mampel, MJ Obregón, F Villarroya 		Biochimica et Biophysica Acta (BBA) - General Subjects 1987
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S Kobayshi, Y Gao, RL Ong, CS Pittman 		Life Sciences 1986
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Comparison of type I 5′-deiodination of thyroxine and of reverse-triiodothyronine in rat and chicken liver homogenates
P Rudas 		General and Comparative Endocrinology 1986
Type-II thyroxine 5′-deiodinase is present in the rat pineal gland
K Tanaka, M Murakami, MA Greer 		Biochemical and Biophysical Research Communications 1986
Requirement of gene transcription and protein synthesis for cold-and norepinephrine-induced stimulation of thyroxine deiodinase in rat brown adipose tissue
R Jones, L Henschen, N Mohell, J Nedergaard 		Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1986
Clinical Endocrinology
A Labhart 		Clinical Endocrinology 1986
Comparative study of pituitary-thyroid hormone economy in fasting and hypothyroid rats
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Metabolic effect of 3,3',5'-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. Evidence for a unique mechanism of thyroid hormone action
DL st Germain 		Journal of Clinical Investigation 1985
Characteristics of thyroxine 5'-deiodination in cultured human placental cells. Regulation by iodothyronines
JT Hidal, MM Kaplan 		Journal of Clinical Investigation 1985
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats
JE Silva, PR Larsen 		Journal of Clinical Investigation 1985
Effects of Iodine and Iodine-Containing Compounds on Thyroid Function
JE Silva 		Medical Clinics of North America 1985
The Dilemma of Abnormal Thyroid Function Tests — Is Thyroid Disease Present or Not?
JE Griffin 		The American Journal of the Medical Sciences 1985
Purification and characterization of a cytosolic protein enhancing GSH-dependent microsomal iodothyronine 5'-monodeiodination
A Goswami, IN Rosenberg 		The Journal of biological chemistry 1985
Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man
SM Lum, JT Nicoloff, CA Spencer, EM Kaptein 		Journal of Clinical Investigation 1984
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats
JE Silva, MB Gordon, FR Crantz, JL Leonard, PR Larsen 		Journal of Clinical Investigation 1984
Production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. Responses to hypothyroidism
JE Silva, PS Matthews 		Journal of Clinical Investigation 1984
Iodothyronine 5'-deiodinase in rat kidney microsomes. Kinetic behavior at low substrate concentrations
A Goswami, IN Rosenberg 		Journal of Clinical Investigation 1984
Somatostatin inhibits rat hepatic T4-5'-deiodinase. The effect is independent of the associated hypoinsulinemia
LA Gavin, M Moeller 		Journal of Clinical Investigation 1983
Adrenergic activation of triiodothyronine production in brown adipose tissue
JE Silva, PR Larsen 		Nature 1983
New Comprehensive Biochemistry
S Yamamoto 		New Comprehensive Biochemistry 1983
TSH neuroregulation and alterations in disease states
JR Peters, SM Foord, C Dieguez, MF Scanlon 		Clinics in Endocrinology and Metabolism 1983

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