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Citations to this article

Characterization of Serum Resistance of Neisseria gonorrhoeae that Disseminate: ROLES OF BLOCKING ANTIBODY AND GONOCOCCAL OUTER MEMBRANE PROTEINS
Peter A. Rice, Dennis L. Kasper
Peter A. Rice, Dennis L. Kasper
Published July 1, 1982
Citation Information: J Clin Invest. 1982;70(1):157-167. https://doi.org/10.1172/JCI110589.
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Characterization of Serum Resistance of Neisseria gonorrhoeae that Disseminate: ROLES OF BLOCKING ANTIBODY AND GONOCOCCAL OUTER MEMBRANE PROTEINS

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Abstract

Neisseria gonorrhoeae isolated from patients with disseminated infection (DGI) often resist complement (C′)-dependent killing by normal human serum (NHS) and less commonly by convalescent DGI serum. 7 of 10 NHS specimens completely inhibited killing of serum-resistant (serr) gonococci by convalescent or immune DGI serum. Immunoglobulin G (IgG) purified from NHS was shown to be the blocking agent. In addition, IgM (plus C′) purified from NHS was shown to be fivefold more effective (wt/wt) in killing serum-sensitive (sers) gonococci than equivalent amounts of IgM tested in the presence of IgG (whole serum). Although inhibition of NHS killing of sers gonococci required a 640% excess of IgG, only a 40% excess was required to block immune serum killing of serr gonococci. F(ab′)2 prepared from IgG also blocked killing of serr gonococci by immune serum indicating antigenic specificity of blocking IgG.

Authors

Peter A. Rice, Dennis L. Kasper

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Total citations by year

Year: 2024 2023 2021 2020 2019 2016 2012 2011 2010 2008 2005 2004 2003 2002 2001 2000 1998 1996 1995 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 Total
Citations: 2 2 1 1 1 1 1 3 2 1 1 1 1 2 1 1 3 1 1 1 2 3 2 5 2 3 3 8 2 1 59
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Citations to this article in year 2012 (1)

Title and authors Publication Year
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012

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Referenced in 9 patents
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