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D T Baran, … , E Slatopolsky, L V Avioli
Published June 1, 1978
Citation Information: J Clin Invest. 1978;61(6):1691-1696. https://doi.org/10.1172/JCI109090.
Citation Information: J Clin Invest. 1978;61(6):1691-1696. https://doi.org/10.1172/JCI109090.
Abstract
Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.
Authors
D T Baran, M P Schwartz, M A Bergfeld, S L Teitelbaum, E Slatopolsky, L V Avioli
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Citations to this article in year 2013 (2)
| Title and authors | Publication | Year |
|---|---|---|
|
Inhibition of caudal fin regeneration in Corydoras aeneus by lithium chloride
O Zarnescu, S Stavri, L Moldovan |
Micron | 2013 |
|
Effects of lithium on extraction socket healing in rats assessed with micro-computed tomography
YT Zeng, B Fu, GH Tang, L Zhang, YF Qian |
Acta Odontologica Scandinavica | 2013 |
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