Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.
D T Baran, M P Schwartz, M A Bergfeld, S L Teitelbaum, E Slatopolsky, L V Avioli
Title and authors | Publication | Year |
---|---|---|
The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas
SK Wong, KY Chin, S Ima-Nirwana |
Frontiers in pharmacology | 2020 |
Endocrinological disorders related to the medical use of lithium. A narrative review
G García-Maldonado, R de Jesús Castro-García |
2019 | |
Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review
MA Makrygiannakis, EG Kaklamanos, AE Athanasiou |
The European Journal of Orthodontics | 2018 |
Alteraciones endocrinas vinculadas a la prescripción médica de carbonato de litio. Una revisión narrativa
G García-Maldonado, RJ Castro-García |
Revista colombiana de psiquiatria | 2017 |
Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats
VS Kagy, LT Muniz, AC Michels, ST Luiz, LR Alanis, JA Brancher, AM Grégio, SA Ignácio, ES Camargo, MÂ Machado, AC Johann, PC Trackman |
PloS one | 2016 |
Systemic Administration of Lithium Improves Distracted Bone Regeneration in Rats
X Wang, S Zhu, X Jiang, Y Li, D Song, J Hu |
Calcified Tissue International | 2015 |
Lithium-end-capped polylactide thin films influence osteoblast progenitor cell differentiation and mineralization: Lithium-End-Capped Polylactide Thin Films
CT Gomillion, RK Lakhman, RM Kasi, RA Weiss, LT Kuhn, AJ Goldberg |
Journal of biomedical materials research. Part A | 2014 |
Inhibition of caudal fin regeneration in Corydoras aeneus by lithium chloride
O Zarnescu, S Stavri, L Moldovan |
Micron | 2013 |
Effects of lithium on extraction socket healing in rats assessed with micro-computed tomography
YT Zeng, B Fu, GH Tang, L Zhang, YF Qian |
Acta Odontologica Scandinavica | 2013 |
Lithium-Associated Hyperparathyroidism: Surgical Strategies in the Era of Minimally Invasive Parathyroidectomy
AR Skandarajah, FF Palazzo, JF Henry |
World Journal of Surgery | 2011 |
Lithium's effect on bone mineral density
A Zamani, GR Omrani, MM Nasab |
Bone | 2009 |
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
P Clément-Lacroix, M Ai, F Morvan, S Roman-Roman, B Vayssière, C Belleville, K Estrera, ML Warman, R Baron, G Rawadi |
Proceedings of the National Academy of Sciences | 2005 |
The effect of lithium on the precipitation of hydroxyapatite from aqueous solutions
PG Koutsoukos, GH Nancollas |
Colloids and Surfaces | 1986 |
Endocrine and Metabolic Effects of Lithium
JH Lazarus, KJ Collard |
1986 | |
Lithium prophylaxis of recurrent affective disorders
AI Glen |
Journal of Affective Disorders | 1985 |
Alterations in human serum alkaline phosphatase and its bone isoenzyme by chronic administration of lithium
PD Broulik, JJ Štěpán, K Souček, V Pacovský |
Clinica Chimica Acta | 1984 |
Lithium effects on calcium, magnesium and phosphate in man: effects on balance, bone mineral content, faecal and urinary excretion
P Plenge, OJ Rafaelsen |
Acta Psychiatrica Scandinavica | 1982 |
Interaction between Li, Ni and Sr content in human cancellous bone
M Knuuttila, R Lappalainen, S Lammi, E Alhava, H Olkkonen |
Chemico-Biological Interactions | 1982 |
Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration
TJ Hahn, LR Halstead, SL Teitelbaum, BH Hahn |
Journal of Clinical Investigation | 1979 |
Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments
DT Baran, JK Burks, CA Richardson, JB Hamilton, LR Halstead, TJ Hahn, SL Teitelbaum, LV Avioli |
Calcified Tissue International | 1979 |