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Research Article Free access | 10.1172/JCI109090

Lithium inhibition of bone mineralization and osteoid formation.

D T Baran, M P Schwartz, M A Bergfeld, S L Teitelbaum, E Slatopolsky, and L V Avioli

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Published June 1, 1978 - More info

Published in Volume 61, Issue 6 on June 1, 1978
J Clin Invest. 1978;61(6):1691–1696. https://doi.org/10.1172/JCI109090.
© 1978 The American Society for Clinical Investigation
Published June 1, 1978 - Version history
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Abstract

Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.

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