The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic dehydrogenase or beta-glucuronidase. A lytic phase involved the slower loss of all platelet constituents. Both phases were inhibited by iodoacetate plus dinitrophenol, suggesting an energy requirement. In ultrastructural studies, lysis of washed platelets which appeared to contain crystals was seen. Urate crystals were also shown to induce serotonin release and platelet lysis in citrated platelet-rich plasma. Since urate crystals are deposited at a variety of sites, urate crystal-platelet interaction in vivo is a possibility. Such interactions, leading to release of platelet constituents, might contribute to gouty inflammation or to enhanced atherogenesis.
M H Ginsberg, F Kozin, M O'Malley, D J McCarty
Year: | 2024 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1994 | 1991 | 1990 | 1989 | 1988 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 2 | 1 | 2 | 4 | 6 | 4 | 5 | 4 | 5 | 5 | 3 | 4 | 1 | 1 | 5 | 4 | 3 | 2 | 3 | 4 | 1 | 3 | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 2 | 3 | 2 | 2 | 8 | 4 | 114 |
Title and authors | Publication | Year |
---|---|---|
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
I Marrocco, F Altieri, I Peluso |
Oxidative medicine and cellular longevity | 2017 |
Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke
YN Mapoure, CM Ayeah, MS Doualla, H Ba, HB Ngahane, S Mbahe, HN Luma |
Stroke Research and Treatment | 2017 |
Association of diabetes mellitus with decline in ankle-brachial index among patients on hemodialysis: A 6-year follow-up study
SC Chen, MY Lee, JC Huang, HC Mai, PL Kuo, JM Chang, HC Chen, YH Yang, X Cheng |
PloS one | 2017 |
Correlation between serum uric acid levels and residual platelet reactivity in patients undergoing PCI
G Ciccarelli, F Mangiacapra, M Pellicano, E Barbato |
Nutrition, Metabolism, and Cardiovascular Diseases | 2017 |
U-shaped relationship between uric acid and residual renal function decline in continuous ambulatory peritoneal dialysis patients: Association of UA with the rate of RRF decline in CAPD patients
YP Hsieh, Y Yang, CC Chang, CT Kor, YK Wen, PF Chiu, CC Lin |
Nephrology (Carlton, Vic.) | 2017 |