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Citations to this article

Release of platelet constituents by monosodium urate crystals.
M H Ginsberg, … , M O'Malley, D J McCarty
M H Ginsberg, … , M O'Malley, D J McCarty
Published November 1, 1977
Citation Information: J Clin Invest. 1977;60(5):999-1007. https://doi.org/10.1172/JCI108880.
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Research Article

Release of platelet constituents by monosodium urate crystals.

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Abstract

The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic dehydrogenase or beta-glucuronidase. A lytic phase involved the slower loss of all platelet constituents. Both phases were inhibited by iodoacetate plus dinitrophenol, suggesting an energy requirement. In ultrastructural studies, lysis of washed platelets which appeared to contain crystals was seen. Urate crystals were also shown to induce serotonin release and platelet lysis in citrated platelet-rich plasma. Since urate crystals are deposited at a variety of sites, urate crystal-platelet interaction in vivo is a possibility. Such interactions, leading to release of platelet constituents, might contribute to gouty inflammation or to enhanced atherogenesis.

Authors

M H Ginsberg, F Kozin, M O'Malley, D J McCarty

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Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1994 1991 1990 1989 1988 1986 1985 1984 1983 1982 1981 1980 1979 1978 Total
Citations: 2 1 2 4 6 4 5 4 5 5 3 4 1 1 5 4 3 2 3 4 1 3 3 3 2 1 1 1 1 1 3 2 1 2 2 3 2 2 8 4 114
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (1)

Title and authors Publication Year
An increase in serum uric acid concentrations is associated with an increase in the Framingham risk score in Korean adults
GE Nam, KS Lee, YG Park, KH Cho, SH Lee, BJ Ko, DH Kim
Clinical Chemistry and Laboratory Medicine 2011

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