Bilirubin pigments were studied in the bile of 20 normal adults, 25 patients with Gilbert's syndrome, 9 children with Crigler-Najjar disease, and 6 patients with hemolysis, to determine how a deficiency of hepatic bilirubin UDP-glucuronosyltransferase would affect the end products of bilirubin biotransformation.
Johan Fevery, Norbert Blanckaert, Karel P. M. Heirwegh
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European Journal of Clinical Investigation | 2003 |
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Journal of Hepatology | 2003 |
Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert’s syndrome
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Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters
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European Journal of Clinical Investigation | 2001 |
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Human Mutation | 2000 |
Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases
B Burchell, M Soars, G Monaghan, A Cassidy, D Smith, B Ethell |
Toxicology Letters | 2000 |
A replication-deficient rSV40 mediates liver-directed gene transfer and a long-term amelioration of jaundice in Gunn rats
BV Sauter, B Parashar, NR Chowdhury, A Kadakol, Y Ilan, H Singh, J Milano, DS Strayer, JR Chowdhury |
Gastroenterology | 2000 |
Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide
BT Kren, B Parashar, P Bandyopadhyay, NR Chowdhury, JR Chowdhury, CJ Steer |
Proceedings of the National Academy of Sciences | 1999 |
Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler-Najjar syndrome type I with a chimeric oligonucleotide
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Proceedings of the National Academy of Sciences | 1999 |
Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation
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New England Journal of Medicine | 1998 |
Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II
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Environmental Health Perspectives | 1997 |
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Pediatric Research | 1997 |
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Journal of Gastroenterology and Hepatology | 1996 |
Current therapy for Crigler-Najjar syndrome type 1: Report of a world registry: Current therapy for Crigler-Najjar syndrome type 1: Report of a world registry
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Hepatology | 1996 |
UDP-Glucuronosyltransferase in gilbert’s syndrome
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Pathology | 1996 |
The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome
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New England Journal of Medicine | 1995 |
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Life Sciences | 1995 |
Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase
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Function and regulation of UDP-glucuronosyltransferase genes in health and liver disease: Report of the seventh international workshop on glucuronidation, september 1993, Pitlochry, Scotland
BB MCRPath., MW Coughtrie, PL Jansen |
Hepatology | 1994 |
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity
FC Kauffman |
1994 | |
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
PJ Bosma, J Seppen, B Goldhoorn, C Bakker, RP Elferink, JR Chowdhury, NR Chowdhury, PL Jansen |
The Journal of biological chemistry | 1994 |
Genetic heterogeneitiy of Crigler-Najjar syndrome type I: A study of 14 cases
P Labrune, A Myara, M Hadchouel, F Ronchi, O Bernard, F Trivin, NR Chowdhury, JR Chowdhury, A Munnich, M Odivre |
Human Genetics | 1994 |
Unveiling the mysteries of inherited disorders of bilirubin glucuronidation
JR Chowdury, NR Chowdury |
Gastroenterology | 1993 |
Prenatal diagnosis of bilirubin-UDP-glucuronosyltransferase deficiency in rats by genomic DNA analysis
TJ Huang, JR Chowdhury, P Lahiri, PC Yerneni, VR Bommineni, IM Arias, NR Chowdhury |
Hepatology | 1992 |
Characterisation of a human bilirubin UDP-glucuronosyltransferase stably expressed in hamster lung fibroblast cell cultures
L Sutherland, S Senafi, T Ebner, DJ Clarke, B Burchell |
FEBS Letters | 1992 |
Responsiveness to phenobarbital in an adult with crigler-najjar disease associated with neurological involvement and skin hyperextensibility
M Persico, M Romano, M Muraca |
Hepatology | 1991 |
The influence of gestational age on bilirubin conjugation in newborns
D Ullrich, J Fevery, A Sieg, T Tischler, J Bircher |
European Journal of Clinical Investigation | 1991 |
The differential diagnosis of Crigler—Najjar disease, types 1 and 2, by bile pigment analysis
M Sinaasappel, PL Jansen |
Gastroenterology | 1991 |
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds
E Arinç, JB Schenkman, E Hodgson |
1991 | |
Endogenous bilirubin excretion in Bolivian squirrel monkeys with a Gilbert's‐like syndrome
BA Myers, ML Bruss, JW George, CE Cornelius |
Journal of Medical Primatology | 1991 |
Pigment Gallstone Disease
BW Trotman |
Gastroenterology Clinics of North America | 1991 |
High-performance liquid chromatographic separation of bilirubin conjugates: The effects of change in molarity and pH
CA Goresky, ER Gordon |
Journal of Chromatography B: Biomedical Sciences and Applications | 1990 |
Proportion of conjugated bilirubin in bile in relation to hepatic bilirubin UDP-glucuronyltransferase activity
Y Adachi, M Yamashita, T Nanno, T Yamamoto |
Clinical Biochemistry | 1990 |
Physico-chemical factors predisposing to pigment gallstone formation in liver cirrhosis
D Alvaro, M Angelico, C Gandin, SG Corradini, L Capocaccia |
Journal of Hepatology | 1990 |
Increase in the relative amount of bilirubin diconjugates in rat bile and serum under infusion of phthaleins and indocyanine green
VA Mesa, JD Groote, J Fevery |
Journal of Hepatology | 1990 |
Effects of uridine diphosphate glucuronosyltransferase activity on the maximal secretion rate of bilirubin conjugates in the rat
WV Steenbergen, J Fevery |
Gastroenterology | 1990 |
Thyroid hormones and the hepatic handling of bilirubin. I. Effects of hypothyroidism and hyperthyroidism on the hepatic transport of bilirubin mono- and diconjugates in the wistar rat
WV Steenbergen, J Fevery, RD Vos, R Leyten, KP Heirwegh, JD Groote |
Hepatology | 1989 |
UDP-glucuronosyltransferases
B Burchell, MW Coughtrie |
Pharmacology & Therapeutics | 1989 |
High-performance liquid chromatographic separation of bilirubin conjugates
CA Goresky, ER Gordon |
Analytical Biochemistry | 1989 |
Monoconjugated bilirubin is a major component of hemolysis-induced gallstones in mice
BW Trotman, CR Nair, SE Bernstein |
Hepatology | 1988 |
Nonbacterial transformation of bilirubin in bile
H Oyabu, M Tabata, F Nakayama |
Digestive Diseases and Sciences | 1987 |
Familial hyperbilirubinaemia
BH Billing |
Journal of Gastroenterology and Hepatology | 1987 |
Plasma bilirubin pigments in health and disease
J Fevery, M Muraca, V Mesa, WV Steenbergen, N Blanckaert |
Molecular Aspects of Medicine | 1987 |
Analysis of bilirubin conjugates in human bile by column liquid chromatography—Changes in their composition in hepatobiliary diseases
M Yamashita, Y Adachi, T Yamamoto |
Journal of Gastroenterology and Hepatology | 1987 |
Relationships between serum bilirubins and production and conjugation of bilirubin
M Muraca, J Fevery, N Blanckaert |
Gastroenterology | 1987 |
Orthotopic liver transplantation for type I Crigler-Najjar syndrome
SS Kaufman, RP Wood, BW Shaw, RS Markin, P Rosenthal, B Gridelli, JA Vanderhoof |
Hepatology | 1986 |
Application of a rapid and efficient h.p.l.c. method to measure bilirubin and its conjugates from native bile and in model bile systems. Potential use as a tool for kinetic reactions and as an aid in diagnosis of hepatobiliary disease
W Spivak, W Yuey |
Biochemical Journal | 1986 |
Regulation of bilirubin glucuronide synthesis in primate (Macaca fascicularis) liver
SC Hauser, JC Ziurys, JL Gollan |
Gastroenterology | 1986 |
Effects of anesthetic agents on bile pigment excretion in the rat
GR Gourley, W Mogilevsky, RA Arend, FL Siegel, GB Odell |
Hepatology | 1985 |
The bilirubin diglucuronide controversy
J Fevery |
Journal of Hepatology | 1985 |
An unusual case of Crigler-Najjar disease in the adult
G Duhamel, N Blanckaert, JM Metreau, AM Préaux, M Bouvry, J Fevery, P Berthelot |
Journal of Hepatology | 1985 |
Characterization of a Gilbert‐Like Syndrome in Squirrel Monkeys (Saimiri sciureus)
CE Cornelius, PA Rodgers, ML Bruss, CE Ahlfors |
Journal of Medical Primatology | 1985 |
A Nonhuman Primate Model of Gilbert's Syndrome
OW Portman, JR Chowdhury, NR Chowdhury, M Alexander, CE Cornelius, IM Arias |
Hepatology | 1984 |
The Liver in Crigler-Najjar Syndrome, Protoporphyria, and Other Metabolic Disorders
JR Bloomer, HL Sharp |
Hepatology | 1984 |
Effect of cimetidine on the metabolism of cholephilic dyes in Gilbert's syndrome
K Kutz, M Deres |
European Journal of Clinical Pharmacology | 1984 |
90. Kongreß: Gehalten zu Wiesbaden vom 29. April bis 3. Mai 1984
JF Bergmann |
1984 | |
Effect of phenobarbital on serum and biliary parameters in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis
BW Trotman, L Shaw, J Roy-Chowdhury, PF Malet, EF Rosato |
Digestive Diseases and Sciences | 1983 |
Analysis of Bilirubins in Biological Fluids by Extraction and Thin-Layer Chromatography of the Intact Tetrapyrroles: Application to Bile of Patients with Gilbert's Syndrome, Hemolysis, or Cholelithiasis
J Fevery, N Blanckaert, P Leroy, R Michiels, KP Heirwegh |
Hepatology | 1983 |
Effect of low-dose phenobarbital on hepatic microsomal udp-glucuronyl transferase activity
N Tavoloni, R Wittman, MJ Jones, PD Berk |
Biochemical Pharmacology | 1983 |
Biochemistry of Gallstone Formation
IA Bouchier |
1983 | |
Bilirubin diglucuronide formation in intact rats and in isolated Gunn rat liver
JR Chowdhury, NR Chowdhury, U Gärtner, AW Wolkoff, IM Arias |
Journal of Clinical Investigation | 1982 |
Pigment gallstone disease: Summary of the national institutes of health-international workshop
BW Trotman, RD Soloway |
Hepatology | 1982 |
Azodipyrroles of unconjugated and conjugated bilirubin using diazotized ethyl anthranilate in dimethyl sulfoxide
BW Trotman, J Roy-Chowdhury, GD Wirt, SE Bernstein |
Analytical Biochemistry | 1982 |
Pathogenesis of Gilbert's syndrome
J Fevery |
European Journal of Clinical Investigation | 1981 |
Mechanism of Bilirubin Diglucuronide Formation in Intact Rats BILIRUBIN DIGLUCURONIDE FORMATION IN VIVO
N Blanckaert, J Gollan, R Schmid |
Journal of Clinical Investigation | 1980 |
Glucuronidation of bilirubin and the occurrence of pigment gallstones in patients with chronic haemolytic diseases
J Fevery, R Verwilghen, TG Tan, JD Groote |
European Journal of Clinical Investigation | 1980 |
Analysis of bilirubin and bilirubin mono- and di-conjugates. Determination of their relative amounts in biological samples
N Blanckaert |
Biochemical Journal | 1980 |
Separation and characterization of bilirubin conjugates by high-performance liquid chromatography
PL Jansen, A Tangerman |
Journal of Chromatography B Biomedical Sciences and Applications | 1980 |
Possible role of a defect in hepatic bilirubin glucuronidation in the initiation of cholesterol gallstones
P Duvaldestin, JL Mahu, JM Metreau, J Arondel, AM Preaux, P Berthelot |
Gut | 1980 |
Bilirubin diglucuronide synthesis by a UDP-glucuronic acid-dependent enzyme system in rat liver microsomes
N Blanckaert, J Gollan, R Schmid |
Proceedings of the National Academy of Sciences | 1979 |
The formation and distribution of bilirubin monoglucuronide and diglucuronide in rat liver slices
MT Campbell, GJ Dutton |
Biochemical Journal | 1979 |
Self-association of unconjugated bilirubin-IX alpha in aqueous solution at pH 10.0 and physical-chemical interactions with bile salt monomers and micelles
MC Carey, AP Koretsky |
Biochemical Journal | 1979 |
Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver
S Onishi, N Kawade, S Itoh, K Isobe, S Sugiyama |
Biochemical Journal | 1979 |
Crigler-Najjar Syndrome (Type I) in an Adult Male
AW Wolkoff, JR Chowdhury, LA Gartner, AL Rose, L Biempica, DR Giblin, D Fink, IM Arias |
Gastroenterology | 1979 |
Gilbert??s Syndrome and Drug Metabolism:
AF Macklon, RL Savage, MD Rawlins |
Clinical Pharmacokinetics | 1979 |
New insights into the classification and mechanisms of hereditary, chronic, non-haemolytic hyperbilirubinaemias
P Berthelot, D Dhumeaux |
Gut | 1978 |
Marked hyperbilirubinemia with Gilbert syndrome and immunohemolytic anemia
AM Lake, JT Truman, HH Bode, JC Tucker, RK Mathis |
The Journal of Pediatrics | 1978 |
Twenty-five years of progress in bilirubin metabolism (1952-77)
BH Billing |
Gut | 1978 |
Bilirubin metabolism: State of the art
R Schmid |
Gastroenterology | 1978 |