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Citations to this article

Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone.
D C Dale, … , I V Guerry D, S M Wolff
D C Dale, … , I V Guerry D, S M Wolff
Published October 1, 1975
Citation Information: J Clin Invest. 1975;56(4):808-813. https://doi.org/10.1172/JCI108159.
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Research Article Article has an altmetric score of 11

Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone.

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Abstract

To study the potential application of glucocorticosteroid administration for the measurement of the bone marrow neutrophil reserve response, blood neutrophil count changes were measured in normal subjects after the administration of intravenous hydrocortisone (25, 50, 100, 200, and 400 mg) and oral prednisone (5, 10, 20, 40, and 80 mg). The upper three doses of both steroids increased the blood neutrophil count by approximately 4,000 cells/mm3. The neutrophilia occurring after hydrocortisone (200 mg) and/or prednisone (40 mg) was compared with that observed after endotoxin (0.8 ng/kg) and etiocholanolone (0.1 mg/kg) in 14 normal subjects, 7 patients with Wegener's granulomatosis on cyclophosphamide therapy and 10 patients with chronic idiopathic neutropenia. The normal responses (mean increase of blood neutrophils/mm3 above base line +/- 1 SEM) were: hydrocortisone 4,220 +/- 320, prednisone 4,610 +/- 360, endotoxin 6,060 +/- 880, and etiocholanolone 3,780 +/- 440. In the patient studies, etiocholanolone gave the smallest mean responses, but, in general, the results were similar for all agents. These data indicate that these glucocorticosteroids can be used as equivalent agents to endotoxin and etiocholanolone for measuring the neutrophil reserve response.

Authors

D C Dale, A S Fauci, I V Guerry D, S M Wolff

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Total citations by year

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Citations: 2 2 5 3 4 6 3 5 10 3 7 4 3 4 2 3 5 3 4 2 3 7 2 3 7 8 3 4 5 6 4 3 5 3 5 7 5 4 6 7 8 8 4 4 9 6 2 4 1 223
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Citations to this article in year 2016 (10)

Title and authors Publication Year
Effects of Systemically Administered Hydrocortisone on the Human Immunome
Matthew J. Olnes, Yuri Kotliarov, Angélique Biancotto, Foo Cheung, Jinguo Chen, Rongye Shi, Huizhi Zhou, Ena Wang, John Tsang, Robert Nussenblatt
Scientific Reports 2016
Immunopathology alters Th17 cell glucocorticoid sensitivity
J Banuelos, Y Cao, SC Shin, NZ Lu
Allergy 2016
A gradient of glucocorticoid sensitivity among helper T cell cytokines
J Banuelos, NZ Lu
Cytokine & Growth Factor Reviews 2016
Inhaled corticosteroids increase blood neutrophil count by decreasing the expression of neutrophil adhesion molecules Mac-1 and L-selectin
Y Pasternak, H Yarden-Bilavsky, Y Kodman, M Zoldan, H Tamary, S Ashkenazi
The American Journal of Emergency Medicine 2016
A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis
MS Abers, MS Ghebremichael, AK Timmons, HS Warren, MC Poznansky, JM Vyas
Open Forum Infectious Diseases 2016
Selection for behavior and hemopoiesis in American mink (Neovison vison)
AG Kizhina, LB Uzenbaeva, VA Ilyukha, LI Trapezova, NN Tyutyunnik, OV Trapezov
Journal of Veterinary Behavior: Clinical Applications and Research 2016
Leukocytosis and Leukemia
P Widick, ES Winer
Primary Care Clinics in Office Practice 2016
Autoimmune and other acquired neutropenias
PE Newburger
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2016
Immunopathology alters Th17 cell glucocorticoid sensitivity
J Banuelos, Y Cao, SC Shin, NZ Lu
Allergy 2016
Dexamethasone promotes granulocyte mobilization by prolonging the half-life of granulocyte-colony-stimulating factor in healthy donors for granulocyte transfusions: DEXAMETHASONE PROLONGS G-CSF HALF-LIFE
IH Hiemstra, JL van Hamme, MH Janssen, TK van Berg, TW Kuijpers
Transfusion 2016

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