Citations to this article
Citation Information: J Clin Invest. 1975;56(4):808-813. https://doi.org/10.1172/JCI108159.
Abstract
To study the potential application of glucocorticosteroid administration for the measurement of the bone marrow neutrophil reserve response, blood neutrophil count changes were measured in normal subjects after the administration of intravenous hydrocortisone (25, 50, 100, 200, and 400 mg) and oral prednisone (5, 10, 20, 40, and 80 mg). The upper three doses of both steroids increased the blood neutrophil count by approximately 4,000 cells/mm3. The neutrophilia occurring after hydrocortisone (200 mg) and/or prednisone (40 mg) was compared with that observed after endotoxin (0.8 ng/kg) and etiocholanolone (0.1 mg/kg) in 14 normal subjects, 7 patients with Wegener's granulomatosis on cyclophosphamide therapy and 10 patients with chronic idiopathic neutropenia. The normal responses (mean increase of blood neutrophils/mm3 above base line +/- 1 SEM) were: hydrocortisone 4,220 +/- 320, prednisone 4,610 +/- 360, endotoxin 6,060 +/- 880, and etiocholanolone 3,780 +/- 440. In the patient studies, etiocholanolone gave the smallest mean responses, but, in general, the results were similar for all agents. These data indicate that these glucocorticosteroids can be used as equivalent agents to endotoxin and etiocholanolone for measuring the neutrophil reserve response.
Authors
D C Dale, A S Fauci, I V Guerry D, S M Wolff
Total citations by year
| Year: | 2025 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1962 | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Citations: | 2 | 2 | 5 | 3 | 4 | 6 | 3 | 5 | 10 | 3 | 7 | 4 | 3 | 4 | 2 | 3 | 5 | 3 | 4 | 2 | 3 | 7 | 2 | 3 | 7 | 8 | 3 | 4 | 5 | 6 | 4 | 3 | 5 | 3 | 5 | 7 | 5 | 4 | 6 | 7 | 8 | 8 | 4 | 4 | 9 | 6 | 2 | 4 | 1 | 223 |
Citations to this article in year 2019 (6)
| Title and authors | Publication | Year |
|---|---|---|
|
MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA A receptors without causing systemic immune suppression
NM Zahn, AT Huber, BN Mikulsky, ME Stepanski, AS Kehoe, G Li, M Schussman, MS Roni, R Kodali, JM Cook, DC Stafford, DA Steeber, LA Arnold |
Basic & Clinical Pharmacology & Toxicology | 2019 |
|
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
LM Franco, M Gadkari, KN Howe, J Sun, L Kardava, P Kumar, S Kumari, Z Hu, ID Fraser, S Moir, JS Tsang, RN Germain |
Journal of Experimental Medicine | 2019 |
|
Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery
XA Zhang, A Yates, N Vasilevsky, JP Gourdine, TJ Callahan, LC Carmody, D Danis, MP Joachimiak, V Ravanmehr, ER Pfaff, J Champion, K Robasky, H Xu, K Fecho, NA Walton, RL Zhu, J Ramsdill, CJ Mungall, S Köhler, MA Haendel, CJ McDonald, DJ Vreeman, DB Peden, TD Bennett, JA Feinstein, B Martin, AL Stefanski, LE Hunter, CG Chute, PN Robinson |
2019 | |
|
Isolated Chronic and Transient Neutropenia
N Singh, S Singh, L Dabrowski |
Cureus | 2019 |
|
Chronic captivity stress in wild animals is highly species-specific
CP Fischer, LM Romero, S Cooke |
Conservation Physiology | 2019 |
|
A Case of Enzootic Bovine Leukosis in a Five-month-old Calf
T WAKATSUKI, S SUGIYAMA, A TAKAOKA, A HASHIDA, C MIZUKAMI, Y HIROSE, K KADOTA, S TAKESHIMA, Y AIDA |
Journal of the Japan Veterinary Medical Association | 2019 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)