Citations to this article
Citation Information: J Clin Invest. 1975;56(4):808-813. https://doi.org/10.1172/JCI108159.
Abstract
To study the potential application of glucocorticosteroid administration for the measurement of the bone marrow neutrophil reserve response, blood neutrophil count changes were measured in normal subjects after the administration of intravenous hydrocortisone (25, 50, 100, 200, and 400 mg) and oral prednisone (5, 10, 20, 40, and 80 mg). The upper three doses of both steroids increased the blood neutrophil count by approximately 4,000 cells/mm3. The neutrophilia occurring after hydrocortisone (200 mg) and/or prednisone (40 mg) was compared with that observed after endotoxin (0.8 ng/kg) and etiocholanolone (0.1 mg/kg) in 14 normal subjects, 7 patients with Wegener's granulomatosis on cyclophosphamide therapy and 10 patients with chronic idiopathic neutropenia. The normal responses (mean increase of blood neutrophils/mm3 above base line +/- 1 SEM) were: hydrocortisone 4,220 +/- 320, prednisone 4,610 +/- 360, endotoxin 6,060 +/- 880, and etiocholanolone 3,780 +/- 440. In the patient studies, etiocholanolone gave the smallest mean responses, but, in general, the results were similar for all agents. These data indicate that these glucocorticosteroids can be used as equivalent agents to endotoxin and etiocholanolone for measuring the neutrophil reserve response.
Authors
D C Dale, A S Fauci, I V Guerry D, S M Wolff
Total citations by year
| Year: | 2025 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1962 | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Citations: | 2 | 2 | 5 | 3 | 4 | 6 | 3 | 5 | 10 | 3 | 7 | 4 | 3 | 4 | 2 | 3 | 5 | 3 | 4 | 2 | 3 | 7 | 2 | 3 | 7 | 8 | 3 | 4 | 5 | 6 | 4 | 3 | 5 | 3 | 5 | 7 | 5 | 4 | 6 | 7 | 8 | 8 | 4 | 4 | 9 | 6 | 2 | 4 | 1 | 223 |
Citations to this article in year 2018 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Multi-dimensional flow cytometry analysis reveals increasing changes in the systemic neutrophil compartment during seven consecutive days of endurance exercise
S van Staveren, T ten Haaf, M Klöpping, B Hilvering, GH Tinnevelt, K de Ruiter, MF Piacentini, B Roelands, R Meeusen, JJ de Koning, JJ Jansen, N Vrisekoop, L Koenderman, A Gaggar |
PloS one | 2018 |
|
Extensive hypopigmented cribriform lesions with fine scaling in a child
A Gupta, K Sardana, P Arora, M Bhardwaj |
Pediatric Dermatology | 2018 |
|
Effect of circadian variation on neutrophil mobilization to the peripheral blood in benign constitutional neutropenia
JT Filho, RD Portugal, M Nucci |
Experimental Hematology | 2018 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)