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Research Article Free access | 10.1172/JCI108075

Binding of the products of prothrombin activation to human platelets.

D M Tollefsen, C M Jackson, and P W Majerus

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Published July 1, 1975 - More info

Published in Volume 56, Issue 1 on July 1, 1975
J Clin Invest. 1975;56(1):241–245. https://doi.org/10.1172/JCI108075.
© 1975 The American Society for Clinical Investigation
Published July 1, 1975 - Version history
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Abstract

Binding of prothrombin and activation intermediates 1 and 2 to human platelets was tested with 125-I-labeled protein preparations. None of these precursors of thrombin bound to platelets under conditions in which high affinity binding of thrombin was observed,nor did they cause platelet aggregation or serotonin release. The molecular conformation required for binding to platelets as well as for induction of platelet aggregation and release is present, therefore, only after the final step in prothrombin activation.

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