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Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS
J. Abuid, P. R. Larsen
J. Abuid, P. R. Larsen
Published July 1, 1974
Citation Information: J Clin Invest. 1974;54(1):201-208. https://doi.org/10.1172/JCI107744.
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Research Article Article has an altmetric score of 3

Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS

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Abstract

In 66 untreated patients with hyperthyroidism, serum triiodothyronine (T3) and thyroxine (T4) concentrations were measured by immunoassay. The mean T3 level was 478±28 ng/100 ml (all values mean±SEM) and the T4 was 20.6±0.6 μg/100 ml. The serum T4/T3 ratio by weight was 48±2 as opposed to a value of 71±3 in euthyroid adults. There was a significant inverse correlation of the T4/T3 ratios with serum T3 (r=0.77; P<0.01) but not with serum T4(r=0.21). These results suggested that relative overproduction of T3 is consistently present in patients with hyperthyroidism.

Authors

J. Abuid, P. R. Larsen

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 1 clinical guideline sources
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