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Research Article Free access | 10.1172/JCI107603

The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.

D M Williams, G R Lee, and G E Cartwright

Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112, USA.

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Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112, USA.

Find articles by Lee, G. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84112, USA.

Find articles by Cartwright, G. in: JCI | PubMed | Google Scholar

Published February 1, 1974 - More info

Published in Volume 53, Issue 2 on February 1, 1974
J Clin Invest. 1974;53(2):665–667. https://doi.org/10.1172/JCI107603.
© 1974 The American Society for Clinical Investigation
Published February 1, 1974 - Version history
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Abstract

Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.

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