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Research Article Free access | 10.1172/JCI107590

Activation of human blood monocytes by products of sensitized lymphocytes.

R E Rocklin, C T Winston, and J R David

Department of Medicine, Robert B. Brigham Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA.

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Department of Medicine, Robert B. Brigham Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA.

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Department of Medicine, Robert B. Brigham Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA.

Find articles by David, J. in: PubMed | Google Scholar

Published February 1, 1974 - More info

Published in Volume 53, Issue 2 on February 1, 1974
J Clin Invest. 1974;53(2):559–564. https://doi.org/10.1172/JCI107590.
© 1974 The American Society for Clinical Investigation
Published February 1, 1974 - Version history
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Abstract

Studies were carried out to determine whether products of activated human lymphocytes altered human monocyte function. Supernatants from sensitized human lymphocytes stimulated by specific antigen were cultured with monolayers of human monocytes. Such monocytes exhibited enhanced adherence to their culture vessels and increased glucose carbon-1 oxidation after 2-3 days of incubation. The substance responsible for these effects was found to elute from Sephadex G-100 gel columns in a fraction with 23,000 mol wt, the same fraction containing human migration inhibitory factor.

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