In Vivo Suppression of the Immune Response to Alloantigen by Cholera Enterotoxin

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Abstract

The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 μg cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2→C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival.

Authors

Christopher S. Henney, Lawrence M. Lichtenstein, Elizabeth Gillespie, Ronald T. Rolley