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Research Article Free access | 10.1172/JCI107481
Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Find articles by Henney, C. in: JCI | PubMed | Google Scholar
Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Find articles by Lichtenstein, L. in: JCI | PubMed | Google Scholar
Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Find articles by Gillespie, E. in: JCI | PubMed | Google Scholar
Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Find articles by Rolley, R. in: JCI | PubMed | Google Scholar
Published November 1, 1973 - More info
The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 μg cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2→C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival.
The mechanism of the immune suppression is apparently related to the known adenylate cyclase stimulatory activities of choleragen.