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Research Article Free access | 10.1172/JCI107481

In Vivo Suppression of the Immune Response to Alloantigen by Cholera Enterotoxin

Christopher S. Henney, Lawrence M. Lichtenstein, Elizabeth Gillespie, and Ronald T. Rolley

Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Find articles by Henney, C. in: PubMed | Google Scholar

Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Find articles by Lichtenstein, L. in: PubMed | Google Scholar

Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Find articles by Gillespie, E. in: PubMed | Google Scholar

Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239

Find articles by Rolley, R. in: PubMed | Google Scholar

Published November 1, 1973 - More info

Published in Volume 52, Issue 11 on November 1, 1973
J Clin Invest. 1973;52(11):2853–2857. https://doi.org/10.1172/JCI107481.
© 1973 The American Society for Clinical Investigation
Published November 1, 1973 - Version history
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Abstract

The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 μg cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2→C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival.

The mechanism of the immune suppression is apparently related to the known adenylate cyclase stimulatory activities of choleragen.

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