Measurement of Inorganic Pyrophosphate in Biological Fluids, ELEVATED LEVELS IN SOME PATIENTS WITH OSTEOARTHRITIS, PSEUDOGOUT, ACROMEGALY, AND UREMIA

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Abstract

A rapid and relatively simple method for measurement of inorganic pyrophosphate (PPi) in biological samples has been described. The mean ±SEM of plasma samples from 94 normal subjects was 1.8±0.06 μM, giving a normal range (99% confidence limits) of 0.16 - 3.40 μmol/liter. Analysis of 17 plasma samples in duplicate showed a standard deviation of 0.18, giving a 99% probability that a single determination of plasma PPi would be ±0.68 μM of the true value.

Authors

Donald C. Silcox, Daniel J. McCarty