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Concise Publication Free access | 10.1172/JCI106995

Transport function of transcobalamin II

Mary E. Rappazzo and Charles A. Hall

Hematology Research Laboratory, Veterans Administration Hospital, Albany, New York 12208

Department of Medicine, Albany Medical College of Union University, Albany, New York 12208

Find articles by Rappazzo, M. in: JCI | PubMed | Google Scholar

Hematology Research Laboratory, Veterans Administration Hospital, Albany, New York 12208

Department of Medicine, Albany Medical College of Union University, Albany, New York 12208

Find articles by Hall, C. in: JCI | PubMed | Google Scholar

Published July 1, 1972 - More info

Published in Volume 51, Issue 7 on July 1, 1972
J Clin Invest. 1972;51(7):1915–1918. https://doi.org/10.1172/JCI106995.
© 1972 The American Society for Clinical Investigation
Published July 1, 1972 - Version history
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Abstract

The uptake of free and bound 57CoB12, principally to transcobalamin II (TC II), was studied in isolated, perfused liver and kidney of the dog. (1) There was good uptake of canine TC II-B12 by both organs. (2) In the liver TC II enhanced uptake over that of free B-12. (3) Renal uptake of free B-12 was greater than that of TC II-B12. Free B-12 was neither lost in the urine nor returned to the circulation. (4) On a per gram tissue basis, renal uptake of TC II-B12 was greater than hepatic. (5) There was renal release or production of TC II (6) Some TC II but more of a larger molecular size binder came from the liver. (7) Passing free B-12 through the kidney enhanced its uptake by the liver. (8) Passing free B-12 through the liver depressed its uptake by the kidney. (9) It is postulated that the distribution of B-12 can be modified by (a) different responses of tissue to TC II-B12, (b) synthesis of TC II by an organ, and (c) the effects of B-12 passing through one organ to another.

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Referenced in 6 patents
4 readers on Mendeley
See more details