Go to
JCI Insight
Citations to this article
Abstract
Hypothyroid rats were examined with conventional renal clearance and micropuncture techniques to elicit the mechanism and site within the nephron responsible for the increased salt and water excretion observed in these animals. When compared with age-matched control rats, a decrease in inulin clearance of 30% (P < 0.001) and in Hippuran clearance of 32% (P < 0.005) was observed in the hypothyroid rats. Absolute excretion of sodium and water was increased 3-fold (P < 0.02) and 2-fold (P < 0.025), respectively, while fractional excretion of sodium and water was increased 4.3-fold (P < 0.02) and 2.9-fold (P < 0.05), respectively, in the hypothyroid animals.
Authors
Ulrich F. Michael, Robert L. Barenberg, Rafaelita Chavez, Carlos A. Vaamonde, Solomon Papper
Total citations by year
Citation information
Citations to this article (83)
| Title and authors | Publication | Year |
|---|---|---|
|
Salt-losing nephropathy associated with severe hypothyroidism.
Liang J, Pyles J, Bhat Z, Alrawi O |
BMJ case reports | 2024 |
|
Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males
Unlu H, Yehia A, Manji K, Manji N, Treviño-Alvarez AM, Cabeza De Baca T, Frye MA, Thomas LF, Abulseoud OA |
Frontiers in Nephrology | 2024 |
|
Protocol and Methods: Role of Levothyroxine on the Progression of Chronic Kidney Disease in Subclinical Hypothyroid Populations (LP-CKD) - A Multicenter Randomized Controlled Trial.
Prasad N, Singh S, Kumar V, Sahay M, Chaudhury AR, Behera MR, Kushwaha RS, Yadav D, Gautam S, Jaiswal A |
Indian journal of nephrology | 2023 |
|
Identification of Protein Changes in the Urine of Hypothyroid Patients Treated with Thyroxine Using Proteomics Approach
A Masood, H Benabdelkamel, AA Jammah, AA Ekhzaimy, AA Alfadda |
ACS Omega | 2021 |
|
THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE
AR Volkova, OD Dygun, IM Abramova, EV Nechaeva, OV Galkina, LA Belyakova |
2019 | |
|
Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics
H Wu, K Uchimura, EL Donnelly, Y Kirita, SA Morris, BD Humphreys |
Cell Stem Cell | 2018 |
|
Subclinical and overt hypothyroidism is associated with reduced glomerular filtration rate and proteinuria: a large cross-sectional population study
YC Chang, CH Chang, YC Yeh, LM Chuang, YK Tu |
Scientific Reports | 2018 |
|
THYROID DYSFUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: THE STATE OF THE PROBLEM AND THE WAYS OF SOLVING
AR Volkova, OD Dygun, BG Lukichev, SV Dora, OV Galkina |
2018 | |
|
Distal renal tubular acidosis in two children with acquired hypothyroidism
NE Guerra-Hernández, KV Ordaz-López, R Vargas-Poussou, L Escobar-Pérez, VM García-Nieto |
Nefrología (English Edition) | 2018 |
|
Unusual Presentation of Central Diabetes Insipidus in a Patient With Neurosarcoidosis
V Sanghi, A Kapoor |
Journal of Investigative Medicine High Impact Case Reports | 2016 |
|
Thyroid dysfunction and kidney disease: An update
P Iglesias, MA Bajo, R Selgas, JJ Díez |
Reviews in Endocrine and Metabolic Disorders | 2016 |
|
Chronic Renal Disease
P Delanaye, AD Rule |
2015 | |
|
Cytochrome P4504A inhibitors attenuate the exaggerated natriuretic response to volume expansion in thyroidectomized rats
C Colombero, M Venara, D Gonzalez, RJ Roman, S Nowicki |
Physiological Reports | 2014 |
|
The relationships between cortisol levels, insulin levels, and thyroid hormones with 24-h urinary sodium excretion in never treated essential hypertensive patients
B Afsar, M Ay |
ARYA Atherosclerosis | 2014 |
|
Hormonal regulation of salt and water excretion: a mathematical model of whole kidney function and pressure natriuresis
R Moss, SR Thomas |
American journal of physiology. Renal physiology | 2014 |
|
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
|
Interactions between thyroid disorders and kidney disease
G Basu, A Mohapatra |
Indian journal of endocrinology and metabolism | 2012 |
|
Rein et dysthyroïdies
M Ponsoye, R Paule, V Gueutin, G Deray, H Izzedine |
Néphrologie & Thérapeutique | 2012 |
|
A Literature Review on the Adverse Effects of Hypothyroidism on Kidney Function
AR Mansourian |
Pakistan Journal of Biological Sciences | 2012 |
|
Severe Hyponatremia in Association with I131 Therapy in a Patient with Metastatic Thyroid Cancer
T Nozu, Y Yoshida, M Ohira, T Okumura |
Internal Medicine | 2011 |
|
Salt sensitivity in experimental thyroid disorders in rats
R Perez-Abud, I Rodríguez-Gómez, AB Villarejo, JM Moreno, R Wangensteen, M Tassi, F O'Valle, A Osuna, F Vargas |
American journal of physiology. Endocrinology and metabolism | 2011 |
|
Hypothyroidism and renal function in patients with systolic heart failure
R Merla, JD Martinez, MA Martinez, W Khalife, S Bionat, J Bionat, A Barbagelata |
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital | 2010 |
|
Interactions between thyroid and kidney function in pathological conditions of these organ systems: A review
I Hoek, S Daminet |
General and Comparative Endocrinology | 2009 |
|
Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine
I Hoek, HP Lefebvre, K Peremans, E Meyer, S Croubels, E Vandermeulen, H Kooistra, JH Saunders, D Binst, S Daminet |
Domestic Animal Endocrinology | 2009 |
|
Disorders of the Posterior Pituitary
LJ Muglia, JA Majzoub |
Pediatric Endocrinology | 2008 |
|
Effect of thyroid hormone on the postnatal renal expression of NHE8
J Gattineni, D Sas, A Dagan, V Dwarakanath, M Baum |
American journal of physiology. Renal physiology | 2008 |
|
Effect of thyroid hormone on the postnatal renal expression of NHE8
J Gattineni, D Sas, A Dagan, V Dwarakanath, M Baum |
American journal of physiology. Renal physiology | 2007 |
|
Thyroid Hormone-Induced Alterations in Membrane Structure-Function Relationships: Studies on Kinetic Properties of Rat Kidney Microsomal Na+,K+-ATPase and Lipid/Phospholipid Profiles
SS Katyare, HR Modi, SP Patel, MA Patel |
Journal of Membrane Biology | 2007 |
|
Thyroid Hormone-Induced Alterations in Membrane Structure-Function Relationships: Studies on Kinetic Properties of Rat Kidney Microsomal Na+,K+-ATPase and Lipid/Phospholipid Profiles
SS Katyare, HR Modi, SP Patel, MA Patel |
The Journal of Membrane Biology | 2007 |
|
Hypothyroidism induces expression of the peptide transporter PEPT2
F Döring, R Schmitt, WM Bernhardt, M Klapper, S Bachmann, H Daniel, DA Groneberg |
Biological Chemistry | 2005 |
|
Pediatric Endocrinology
PS Thornton |
Pediatric Endocrinology | 2005 |
|
Thyroid hormone modulates renin and ANG II receptor expression in fetal sheep
K Chen, LC Carey, NK Valego, J Liu, JC Rose |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
|
Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability
M Baum, R Quigley |
American journal of physiology. Renal physiology | 2004 |
|
Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys
R Schmitt, T Kahl, K Mutig, S Bachmann |
Histochemistry and Cell Biology | 2004 |
|
Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins
MA Cadnapaphornchai, YW Kim, AK Gurevich, SN Summer, S Falk, JM Thurman, RW Schrier |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats
R Schmitt, E Klussmann, T Kahl, DH Ellison, S Bachmann |
American journal of physiology. Renal physiology | 2003 |
|
Molecular basis of renal handling of calcium in response to thyroid hormone status of rat
Vivek Kumar, Rajendra Prasad |
Biochimica et Biophysica Acta | 2002 |
|
Maturation of proximal straight tubule NaCl transport: role of thyroid hormone
M Shah, R Quigley, M Baum |
American journal of physiology. Renal physiology | 2000 |
|
Thyroid hormone stimulates the renal Na/H exchanger NHE3 by transcriptional activation
A Cano, M Baum, OW Moe |
The American journal of physiology | 1999 |
|
Abnormal taste preference for saccharin in hypothyroid rats
BH Gordon, GY Wong, J Liu, RS Rivlin |
Physiology & Behavior | 1992 |
|
Short-Term Hypothyroidism and Vasopressin Gene Expression in the Rat
RL Howard, S Summer, N Rossi, JK Kim, RW Schrier |
American Journal of Kidney Diseases | 1992 |
|
Effects of thyroid hormones on urinary and renal kallikreins
S Avigdor, F Alhenc-Gelas, J Bouhnik |
American journal of physiology. Endocrinology and metabolism | 1992 |
|
The Protective Mechanism of Thyroidectomy in a Rat Model of Chronic Renal Failure
JD Conger, SA Falk, DM Gillum |
American Journal of Kidney Diseases | 1989 |
|
Thyroid hormones and renal transport: Cellular and biochemical aspects
G Capasso, NG de Santo, R Kinne |
Kidney International | 1987 |
|
Response of the medullary thick ascending limb to hypothyroidism in the rat
AG Bentley, KM Madsen, RG Davis, CC Tisher |
The American Journal of Pathology | 1985 |
|
Thyroid hormones increase Na+-H+ exchange activity in renal brush border membranes
J Kinsella, B Sacktor |
Proceedings of the National Academy of Sciences | 1985 |
|
Renal concentrating ability in obesity. Effect of modified fasting and the supplementation of T3, sodium chloride and carbohydrate
HP Koppeschaar, AE Meinders, F Schwarz |
Metabolism | 1985 |
|
Regulation of volume reabsorption by thyroid hormones in the proximal tubule of rat: Minor role of luminal sodium permeability
G Capasso, E Kinne-Saffran, NG Santo, R Kinne |
Pflügers Archiv - European Journal of Physiology | 1985 |
|
Short term effect of low doses of tri-iodothyronine on proximal tubular membrane Na−K-ATPase and potassium permeability in thyroidectomized rats
G Capasso, , NG Santo, R Kinne |
Pflügers Archiv - European Journal of Physiology | 1985 |
|
Effects of thyroid status on renal calcium and magnesium handling
C McCaffrey, GA Quamme |
Canadian journal of comparative medicine. Revue canadienne de médecine comparée | 1984 |
|
Kidney structure in hypothyroidism
RG Davis, KM Madsen, MJ Fregly, CC Tisher |
The American Journal of Pathology | 1983 |
|
X-ray microanalysis of cardiocytes in the Snell dwarf mouse
NK Smith, A Lewiński, A Bartke, S Stabler-Morris |
Biochemical and Biophysical Research Communications | 1983 |
|
Effect of experimental hyperthyroidism on the elemental content of rat hepatocytes
NK Smith, A Lewiński, S Stabler-Morris |
Biochemical and Biophysical Research Communications | 1983 |
|
Current Topics in Membranes and Transport
J Gliemann, WD Rees |
Current Topics in Membranes and Transport | 1983 |
|
Renal tubular sodium reabsorption and oxygen consumption in the hypothyroid dog
B Rosenbaum, VA DiScala |
Metabolism | 1982 |
|
Changes in glomerulotubular dimensions, single nephron glomerular filtration rates and the renin-angiotensin system in hypothyroid rats
SE Bradley, JB Coelho, JE Sealey, KD Edwards, F Stéphan |
Life Sciences | 1982 |
|
Tubular transport processes in proximal tubules of hypothyroid rats. Lack of relationship between thyroidal dependent rise of isotonic fluid reabsorption and Na+−K+-ATPase activity
NG Santo, G Capasso, R Kinne, B Moewes, C Carella, P Anastasio, C Giordano |
Pflügers Archiv - European Journal of Physiology | 1982 |
|
Effect of triiodothyronine on renal growth and renal sodium reabsorption in hypothyroid rats
CS Lo, D Gerendasy, TN Lo |
Pflügers Archiv - European Journal of Physiology | 1981 |
|
Thyroid Function in a Uremic Rat Model EVIDENCE SUGGESTING TISSUE HYPOTHYROIDISM
VS Lim, C Henriquez, H Seo, S Refetoff, E Martino |
Journal of Clinical Investigation | 1980 |
|
RENIN AND ALDOSTERONE IN HYPOTHYROIDISM: RELATION TO EXCRETION OF SODIUM AND POTASSIUM
T Saruta, W Kitajima, M Hayashi, E Kato, S Matsuki |
Clinical Endocrinology | 1980 |
|
[Hypothyroid hyponatremia: dilution defect non-correctable with demeclocycline]
C Caron, GE Plante, R Bélanger, T Nawar |
Canadian Medical Association journal | 1980 |
|
Inhibition of the anti-natriuretic action of aldosterone by thyroid hormone in the rat
J Diezi, M Nenniger, BC Rossier |
Pflügers Archiv - European Journal of Physiology | 1980 |
|
Tubular transport processes in proximal tubules of hypothyroid rats: Micropuncture studies on isotonic fluid, amino acid and buffer reabsorption
NG Santo, G Capasso, C Paduano, C Carella, C Giordano |
Pflügers Archiv - European Journal of Physiology | 1980 |
|
Neurohypophyseal peptides in hypothyroid rats: Plasma levels and kidney response
SM Seif, AG Robinson, TV Zenser, BB Davis, AB Huellmantel, C Haluszczak |
Metabolism | 1979 |
|
Effectors of Thermogenesis
L Girardier, J Seydoux |
1978 | |
|
Renal Pharmacology
M Martinez-Maldonado |
1978 | |
|
Urinary sodium and calcium in various dog models and relationship to endogenous plasma glucagon
C Bornhof, PO Schwille |
Urological Research | 1977 |
|
Renal studies in the hypothyroid rat
MJ Kinney |
Metabolism | 1977 |
|
Hormonal control of renal water excretion
KM McDonald, PD Miller, RJ Anderson, T Berl, RW Schrier |
Kidney International | 1976 |
|
Effects of L-Thyroxine in acute renal failure
E Straub |
Research in Experimental Medicine | 1976 |
|
The activity of mitochondrial α-glycerophosphate dehydrogenase in the rat nephron following triiodo-L-Thyronine treatment
NO Jacobsen |
Histochemistry | 1976 |
|
Oxygen Transport to Tissue — II
J Grote, D Reneau, G Thews |
1976 | |
|
Impaired urinary acidification in the hypothyroid rat
UF Michael, R Chavez, SL Cookson, CA Vaamonde |
Pflügers Archiv - European Journal of Physiology | 1976 |
|
Methods in Pharmacology
M Martinez-Maldonado, A Schwartz |
1976 | |
|
Dependence of renal (Na+ + k+)-adenosine triphosphatase activity on thyroid status
SC Lo, TR August, UA Liberman, IS Edelman |
The Journal of biological chemistry | 1976 |
|
The activity of mitochondrial α-glycerophosphate dehydrogenase in the rat nephron following triiodo-L-Thyronine treatment: A. Histochemical study
NO Jacobsen |
Histochemistry | 1976 |
|
Nonosmolar Factors Affecting Renal Water Excretion
RW Schrier, T Berl |
New England Journal of Medicine | 1975 |
|
Thyroidal Regulation of Renal Energy Metabolism and (Na+ + K+)-Activated Adenosine Triphosphatase Activity
IS Edelman |
Medical Clinics of North America | 1975 |
|
The basic requirements for the function of the isolated cell free perfused rat kidney
HJ Schurek, JP Brecht, H Lohfert, K Hierholzer |
Pflügers Archiv - European Journal of Physiology | 1975 |
|
Mechanism of Impaired Water Excretion in the Hypothyroid Rat
DS Emmanouel, MD Lindheimer, AI Katz |
Journal of Clinical Investigation | 1974 |
|
The thyroid and the kidney
SE Bradley, F Stéphan, JB Coelho, P Réville |
Kidney International | 1974 |
|
Studies of glomerulotubular interaction
SE Bradley, JB Coelho |
Transactions of the American Clinical and Climatological Association | 1974 |
|
Renal Sodium- and Potassium-Activated Adenosine Triphosphatase and Sodium Reabsorption in the Hypothyroid Rat
AI Katz, MD Lindheimer |
Journal of Clinical Investigation | 1973 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)