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Citations to this article

Interruption of the enterohepatic circulation of digitoxin by cholestyramine: I. Protection against lethal digitoxin intoxication
James H. Caldwell, Norton J. Greenberger
James H. Caldwell, Norton J. Greenberger
Published December 1, 1971
Citation Information: J Clin Invest. 1971;50(12):2626-2637. https://doi.org/10.1172/JCI106763.
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Interruption of the enterohepatic circulation of digitoxin by cholestyramine: I. Protection against lethal digitoxin intoxication

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Abstract

Previous studies have demonstrated that considerable amounts of parenterally administered cardiac glycosides are excreted in the bile and reabsorbed across the intestinal mucosa in several species. It is currently believed that the more prolonged action of nonpolar digitalis glycosides is due to their retention and recycling in the enterohepatic circulation. This report describes studies carried out to evaluate the effects of pharmacologic interruption of this enterohepatic cycle with the intraluminal sequestering agent cholestyramine.

Authors

James H. Caldwell, Norton J. Greenberger

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Total citations by year

Year: 2021 2020 2018 2003 2002 2001 1997 1991 1988 1985 1984 1983 1982 1981 1980 1978 1977 1976 1975 1974 1973 1972 1962 Total
Citations: 1 1 1 1 1 1 1 1 2 5 5 4 9 4 1 7 3 3 4 1 2 1 1 60
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (60)

Title and authors Publication Year
Pharmacological aspects of acute treatment glycoside intoxication
MI Sperling, EG Kruchinin, AS Gogolevsky
2021
Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan
X Gong, Q Zhang, Y Ruan, M Hu, Z Liu, L Gong
Alcohol and Alcoholism 2020
Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review
C Litou, A Effinger, ES Kostewicz, KJ Box, N Fotaki, JB Dressman
The Journal of pharmacy and pharmacology 2018
Verapamil regulates activity and mRNA-expression of human ?-glucuronidase in HepG2 cells
M Grube, C Kunert-Keil, B Sperker, HK Kroemer
Naunyn-Schmiedeberg's Archives of Pharmacology 2003
Absence of a pharmacokinetic interaction between digoxin and levofloxacin
SC Chien, MC Rogge, RR Williams, J Natarajan, F Wong, AT Chow
Journal of Clinical Pharmacy and Therapeutics 2002
Sevelamer Hydrochloride (Renagel®), a Nonabsorbed Phosphate-Binding Polymer, Does Not Interfere with Digoxin or Warfarin Pharmacokinetics
S Burke, N Amin, C Incerti, M Plone, N Watson
The Journal of Clinical Pharmacology 2001
The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans:
B Sperker, JT Backman, HK Kroemer
Clinical Pharmacokinetics 1997
Digoxin Toxicity in the Aged: Characterising and Avoiding the Problem
AP Passmore, GD Johnston
Drugs & Aging 1991
Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide
PJ Neuvonen, K Kivistö, EL Hirvisalo
British Journal of Clinical Pharmacology 1988
Digitalis: An Update of Clinical Pharmacokinetics, Therapeutic Monitoring Techniques and Treatment Recommendations
AD Mooradian
Clinical Pharmacokinetics 1988
Pharmacokinetic interactions between digoxin and other drugs
FI Marcus
Journal of the American College of Cardiology 1985
Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man
MN Cayen
Pharmacology & Therapeutics 1985
Digitalis: where are we now?
DA Chamberlain
British heart journal 1985
Digoxin Specific Antibody (Fab) Fragments in 34 Cases of Severe Digitalis Intoxication
A Smolarz, E Roesch, E Lenz, H Neubert, P Abshagen
Journal of Toxicology: Clinical Toxicology 1985
The Effects of Activated Charcoal on Digoxin and Digitoxin Clearance
GD Park, MJ Goldberg, R Spector, GF Johnson, RD Feldman, CK Quee, P Roberts, JF Feliu, I Lukosevicius
1985
Diagnosis and Management of Digitalis Intoxication
SK Huang, FI Marcus
Journal of Cardiovascular Electrophysiology 1984
DRUG INTERACTIONS IN ANTIARRHYTHMIC THERAPY
JT Bigger, EG Giardina
Annals of the New York Academy of Sciences 1984
Effects of cholestyramine and colestipol on the plasma concentrations of propranolol
DM Hibbard, JR Peters, DB Hunninghake
British Journal of Clinical Pharmacology 1984
THERAPEUTIC PROGRESS—REVIEW XIII
DA Boldy, BM Buckley, JA Vale
Journal of Clinical Pharmacy and Therapeutics 1984
Enhancement of Xenobiotic Elimination: Role of Intestinal Excretion
ZH Israili, PG Dayton
Drug Metabolism Reviews 1984
Biliary excretion and enterohepatic circulation of paracetamol in the rat
CP Siegers, K Rozman, CD Klaassen
Xenobiotica 1983
Cholestyramine Resin in the Treatment of Digitoxin Toxicity
AM Baciewicz, ML Isaacson, GL Lipscomb
1983
Herzrhythmusstörungen
G Breithardt, B Brisse, E Jähnchen, W Kasper, HJ Knieriem, ER von Leitner, B Lüderitz, P Matthiesen, D Mecking, T Meinertz, CN dAlnoncourt, H Nawrath, H Neuss, J Ostermeyer, M Schlepper, L Seipel, G Steinbeck, K Theisen, J Thormann, D Trenk, HA Tritthart
1983
Wandlungen in der Therapie der Herzinsuffizienz
N Rietbrock, B Schnieders, J Schuster
1983
Digitalis
KO Haustein
Pharmacology & Therapeutics 1982
Suicidal digoxin poisoning: Conventional treatment and antibody therapy
T Hess, HU Dubach, G Scholtysik, W Riesen
Klinische Wochenschrift 1982
Studies on the in vitro binding of D-penicillamine to cholestyramine
H Allgayer, W Kruis, G Paumgartner
Experientia 1982
The effect of oral castor oil on the disposition of methyprylon in intoxicated dogs
PR Gwilt, MC Pankaskie, JJ Mitala
Canadian Anaesthetists’ Society Journal 1982
Effect of cholestyramine on the disposition of pentachlorophenol in rhesus monkeys
T Rozman, L Ballhorn, K Rozman, C Klaassen, H Greim
Journal of Toxicology and Environmental Health 1982
Effect of mineral oil and/or cholestyramine in the diet on biliary and intestinal elimination of 2,4,5,2′,4′,5′‐hexabromobiphenyl in the rhesus monkey
KK Rozman, TA Rozman, J Williams, HA Greim
Journal of Toxicology and Environmental Health 1982
Massive digitoxin intoxication. Treatment by amberlite XAD 4 resin hemoperfusion
D Mathieu, B Gosselin, M Nolf, B Dupuis, X Marchandise, M Boidein, F Wattel
Journal of Toxicology: Clinical Toxicology 1982
The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery
CJ Packard, J Shepherd
Journal of lipid research 1982
Clinical Pharmacokinetics of Oral Activated Charcoal in Acute Intoxications:
PJ Neuvonen
Clinical Pharmacokinetics 1982
Properties of Agarose-Encapsulated Adsorbents I. Adsorption of Dixogin from Human Serum
CJ Holloway, K Harstick, G Brunner, I Haeger
Artificial Cells, Blood Substitutes and Biotechnology 1981
Enhanced fecal elimination of stored hexachlorobenzene from rats and rhesus monkeys by hexadecane or mineral oil
K Rozman, T Rozman, H Greim
Toxicology 1981
La digitoxinémie. Etude comparative après administration de gouttes et de comprimés de digitaline
R Bloch, C Steimer, J Schwartz
La Revue de Médecine Interne 1981
Acute, Massive Poisoning with Digitoxin: Report of Seven Cases and Discussion of Treatment
V Hansteen, D Jacobsen, K Knudsen, Å Reikvam, BJ Skuterud
Clinical Toxicology 1981
Intestinal secretion of digoxin in the rat: Augmentation by feeding activated charcoal
JH Caldwell, PB Caldwell, JW Murphy, CW Beachler
Naunyn-Schmiedeberg's Archives of Pharmacology 1980
Digoxin and digitoxin elimination in man by charcoal hemoperfusion
HJ Gilfrich, S Okonek, M Manns, CJ Schuster
Klinische Wochenschrift 1978
Interaction by Cholestyramine on the Uptake of Hydrocortisone in the Gastrointestinal Tract
C Johansson, U Adamsson, U Stierner, T Lindsten
Acta Medica Scandinavica 1978
ATOPY AND COW'S MILK
RJ Wolstenholme
The Lancet 1978
TREATMENT OF MASSIVE DIGITOXIN OVERDOSE BY CHARCOAL HÆMOPERFUSION AND CHOLESTYRAMINE
HJ Gilfrich, W Kasper, T Meinertz, S Okonek, R Bork
The Lancet 1978
Decreased bioavailability of digoxin due to hypocholesterolemic interventions
DD Brown, RP Juhl, SL Warner
Circulation 1978
84. Kongreß
B Schlegel
1978
Drug Interactions with Digitalis Glycosides:
PF Binnion
Drugs 1978
Reversal of Advanced Digitoxin Toxicity and Modification of Pharmacokinetics by Specific Antibodies and Fab Fragments
HR Ochs, TW Smith
Journal of Clinical Investigation 1977
Effect of cholestyramine on digoxin absorption and excretion in man
WH Hall, SD Shappell, JE Doherty
The American Journal of Cardiology 1977
Clinical Pharmacokinetics of Digitoxin:
D Perrier, M Mayersohn, FI Marcus
Clinical Pharmacokinetics 1977
Digitalis Assay and Its Clinical Application
S Oparil
Medical Clinics of North America 1976
Inhibition of Digoxin Absorption by Neomycin
J Lindenbaum, RM Maulitz, VP Butler
Gastroenterology 1976
Bioavailability of Prednisolone During Simultaneous Treatment with Cholestyramine
V Audétat, J Bircher
Gastroenterology 1976
Pharmacokinetics of tritiated ouabain, digoxin and digitoxin in guinea-pigs
D Proppe
Clinical and Experimental Pharmacology and Physiology 1975
Cardiovascular Drug Interactions
DE Hutcheon
The Journal of Clinical Pharmacology 1975
Biliary Excretion of Xenobiotics
CD Klaassen, GL Plaa
Critical Reviews in Toxicology 1975
Concepts in Biochemical Pharmacology
JR Gillette, JR Mitchell
1975
Clinical Pharmacy CASE Studies: Case Number 26 Digitalis Toxicity
MM McCarron, LK Porter
1974
Effect of cholestyramine on absorption of3H digoxin in rats
WG Thompson
The American Journal of Digestive Diseases 1973
Antiarrhythmic Agents1 II: Therapeutic Considerations
DT Mason, AN DeMaria, EA Amsterdam, R Zelis, RA Massumi
Drugs 1973
Contribution of Quantitative Assay Technics to the Understanding of the Clinical Pharmacology of Digitalis
TW Smith
Circulation 1972
Cardiac Glycosides
DG Friend
New England Journal of Medicine 1962

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