Effect of renal vasodilatation on the distribution of cortical blood flow in the kidney of the dog

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Abstract

Studies were performed to evaluate the validity of using the radioactive microsphere technique to measure regional blood flow in the renal cortex. A technique was developed in which the renal cortex was divided into four equal zones, and the fractional and absolute distribution of blood flow in these zones was determined. It was consistently found that approximately 70% of the renal blood flow was distributed to the two outer cortical zones with the remaining 30% going to the two inner cortical zones. In addition, there was a reproducible pattern of distribution of blood flow in different areas of the same kidney after a single injection of microspheres and in the same area of the kidney after multiple injections of microspheres.

Authors

Jay H. Stein, Thomas F. Ferris, James E. Huprich, Timothy C. Smith, Richard W. Osgood