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Research Article Free access | 10.1172/JCI106446

Mixed leukocyte reactivity and leukemia: study of identical siblings

Robert H. Rudolph, Eric Mickelson, and E. Donnall Thomas

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

U. S. Public Health Service Hospital, Seattle, Washington 98144

Find articles by Rudolph, R. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

U. S. Public Health Service Hospital, Seattle, Washington 98144

Find articles by Mickelson, E. in: JCI | PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105

U. S. Public Health Service Hospital, Seattle, Washington 98144

Find articles by Thomas, E. in: JCI | PubMed | Google Scholar

Published December 1, 1970 - More info

Published in Volume 49, Issue 12 on December 1, 1970
J Clin Invest. 1970;49(12):2271–2275. https://doi.org/10.1172/JCI106446.
© 1970 The American Society for Clinical Investigation
Published December 1, 1970 - Version history
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Abstract

This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stimulate the cells of the normal twin, nor did cells from the normal twin stimulate cells from the leukemic patient. Possible explanations for the failure to detect a leukemia-associated antigen in these studies are discussed.

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