This report describes a search for tumor-specific transplantation antigens in man by testing four sets of identical siblings using the mixed leukocyte transformation reaction. In each case, one member of the set had acute leukemia in relapse. In no instance did the leukemic cells of the patient stimulate the cells of the normal twin, nor did cells from the normal twin stimulate cells from the leukemic patient. Possible explanations for the failure to detect a leukemia-associated antigen in these studies are discussed.
Robert H. Rudolph, Eric Mickelson, E. Donnall Thomas
Title and authors | Publication | Year |
---|---|---|
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken |
Advances in Cancer Research Volume 110 | 2011 |
Allogeneic bone marrow transplantation for acute leukemia refractory to induction chemotherapy
AR Zander, KA Dicke, M Keating, L Vellekoop, S Culbert, G Spitzer, M Kanojia, S Jagannath, S Schell, J Hester, R Ayyar, D Verma, K McCredie, L Peters, CH Poynton, EJ Freireich |
Cancer | 1985 |
Leukaemia-associated antigens in man
T Mohanakumar, RB Raney |
Clinics in Haematology | 1978 |
Postmyocardial infarction (Dressler's) syndrome: Report of a case with immunological and viral studies
HL Kennedy, SK Das |
American Heart Journal | 1976 |
Immunological aspects of acute leukemia in man
WF Piessens, WC Moloney |
European Journal of Cancer (1965) | 1976 |
Leukaemia antigens. Stimulation of lymphocytes in mixed culture by cells from HL-A identical siblings
A Fefer, E Mickelson, ED Thomas |
Clinical & Experimental Immunology | 1976 |
Lymphocyte reactivity to autochthonous tumor cells in dogs with spontaneous malignancies
MS Tsoi, PL Weiden, R Storb |
Cellular Immunology | 1974 |
Leukaemia antigens: mixed leucocyte culture tests on twelve leukaemic patients with identical twins
A Fefer, E Mickelson, ED Thomas |
Clinical & Experimental Immunology | 1974 |
Investigation and Stimulation of Immunity in Cancer Patients
G Mathé, R Weiner |
1974 | |
Paroxysmal Nocturnal Haemoglobinuria and Refractory Marrow Failure Treated by Marrow Transplantation
R Storb, RS Evans, ED Thomas, CD Buckner, RA Clift, A Fefer, P Neiman, SE Wright |
British Journal of Haematology | 1973 |
LEUKAEMIC ANTIGENS
GD Pegrum |
British Journal of Haematology | 1973 |
Selection of Leukaemic Cell Populations by Freezing and Thawing
J Farrant, SC Knight, JA O'brien, GJ Morris |
Nature | 1973 |
Failure to demonstrate immunity to leukemia associated antigens by lymphocyte transformationin vitro
M Schweitzer, CJ Melief, VP Eijsvoogel |
International Journal of Cancer | 1973 |
LEUKÆMIC TRANSFORMATION OF ENGRAFTED HUMAN MARROW CELLS IN VIVO
ED Thomas, CD Buckner, A Fefer, P Neiman, JI Bryant, RA Clift, FL Johnson, RE Ramberg, R Storb |
The Lancet | 1972 |
APLASTIC ANAEMIA TREATED BY MARROW TRANSPLANTATION
ED Thomas, R Storb, A Fefer, SJ Slichter, JI Bryant, CD Buckner, PE Neiman, RA Clift, DD Funk, KE Lerner |
The Lancet | 1972 |
Transplantation Antigens
FT Rapaport |
Transplantation Antigens | 1972 |
Antigen Solubilized from Human Leukemia: Lymphocyte Stimulation
JU Gutterman, G Mavligit, KB McCredie, GP Bodey, EJ Freireich, EM Hersh |
Science | 1972 |
HL-A ANTIGENS AND CHORIOCARCINOMA
RH Rudolph, ED Thomas |
The Lancet | 1971 |
Changing Concepts of Treatment in Acute Leukemia
BD Clarkson, J Fried |
Medical Clinics of North America | 1971 |