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Usage Information

Aggregation of γG3 proteins: relevance to the hyperviscosity syndrome
J. D. Capra, H. G. Kunkel
J. D. Capra, H. G. Kunkel
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Research Article

Aggregation of γG3 proteins: relevance to the hyperviscosity syndrome

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Abstract

Studies on the sera and isolated proteins from 14 patients with γG3 multiple myeloma revealed a concentration- and temperature-dependent aggregation which was not encountered in 26 sera from patients with multiple myeloma involving other γG subgroups. When the γG3 myeloma sera were diluted and characterized by analytical ultracentrifugation, complex formation was minimal. However, when these sera were examined undiluted, marked complex formation was observed. Studies on the isolated proteins, their enzymatic fragments, as well as their heavy and light polypeptide chains localized the aggregating sites to the Fd fragment of the heavy chains. The findings were also documented by acrylamide-gel electrophoresis and capillary tube viscometry.

Authors

J. D. Capra, H. G. Kunkel

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 283 32
PDF 114 18
Figure 0 3
Scanned page 739 1
Citation downloads 113 0
Totals 1,249 54
Total Views 1,303
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