An inhibitory effect of furosemide on sodium reabsorption by the proximal tubule of the rat nephron

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Abstract

The evidence from previous micropuncture studies for an inhibitory effect of furosemide on proximal sodium reabsorption in the rat has been conflicting. Intrinsic reabsorptive capacity, estimated in free flow and shrinking drop experiments, has been reported to be depressed, whereas fractional reabsorption usually remains unchanged.

Authors

Barry M. Brenner, Robert I. Keimowitz, Fred S. Wright, Robert W. Berliner