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Usage Information

Plasma Lipoproteins in Liver Disease: I. Immunologically Distinct Low-Density Lipoproteins in Patients with Biliary Obstruction
Sam Switzer
Sam Switzer
Published November 1, 1967
Citation Information: J Clin Invest. 1967;46(11):1855-1866. https://doi.org/10.1172/JCI105676.
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Research Article Article has an altmetric score of 3

Plasma Lipoproteins in Liver Disease: I. Immunologically Distinct Low-Density Lipoproteins in Patients with Biliary Obstruction

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Abstract

Sera from patients with extrahepatic biliary obstruction were found to have an abnormal lipoprotein (obstructive lipoprotein) which failed to react with antibodies to normal lipoproteins of d < 1.063. Preparations of this abnormal lipoprotein made by a combination of immunoprecipitation and multiple polyanion precipitations revealed a high content of free cholesterol (26%) and phospholipids (61%) but only trace amounts of cholesterol esters and triglycerides. Protein content varied from 13% to a corrected low of 5% when ultracentrifugation was also performed. Amino acid analyses of the latter preparations resembled that of lipoproteins of d < 1.006.

Authors

Sam Switzer

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