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Usage Information

Ceruloplasmin in Wilson's Disease
Neil A. Holtzman, Michael A. Naughton, Frank L. Iber, Bonnie M. Gaumnitz
Neil A. Holtzman, Michael A. Naughton, Frank L. Iber, Bonnie M. Gaumnitz
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Research Article

Ceruloplasmin in Wilson's Disease

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Abstract

Ceruloplasmin was highly purified from one patient with Wilson's disease and partially purified from a second unrelated patient. The highly purified ceruloplasmin was indistinguishable from normal ceruloplasmin by electrophoresis, tryptic peptide map, oxidase activity, and copper, amino acid, and sugar composition. The partially purified ceruloplasmin was indistinguishable electrophoretically from normal ceruloplasmin. With penicillamine therapy, ceruloplasmin disappeared from the serum of the first patient; it reappeared after the drug was discontinued. The significance of this observation in regard to the basic defect in Wilson's disease is discussed.

Authors

Neil A. Holtzman, Michael A. Naughton, Frank L. Iber, Bonnie M. Gaumnitz

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 298 37
PDF 177 6
Figure 0 2
Scanned page 858 4
Citation downloads 204 0
Totals 1,537 49
Total Views 1,586
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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