Peroxidative Hemolysis of Red Blood Cells from Patients with Abetalipoproteinemia (Acanthocytosis)

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Abstract

The effect of peroxidative stress on tissue was studied by exposure of red blood cells (RBC) from patients with abetalipoproteinemia to minute amounts of H2O2in vitro. Red blood cells from untreated patients showed a marked sensitivity to H2O2, as evidenced by hemolysis and lipid peroxidation (peroxidative hemolysis).

Authors

James T. Dodge, Gerald Cohen, Herbert J. Kayden, Gerald B. Phillips