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Research Article Free access | 10.1172/JCI104735

THE “INDUCTION” OF DIHYDROFOLIC REDUCTASE ACTIVITY IN LEUKOCYTES AND ERYTHROCYTES OF PATIENTS TREATED WITH AMETHOPTERIN

J. R. Bertino, D. M. Donohue, B. Simmons, B. W. Gabrio, R. Silber, and F. M. Huennekens

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Bertino, J. in: PubMed | Google Scholar

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Donohue, D. in: PubMed | Google Scholar

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Simmons, B. in: PubMed | Google Scholar

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Gabrio, B. in: PubMed | Google Scholar

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Silber, R. in: PubMed | Google Scholar

Department of Medicine, University of Washington and King County Blood Bank, Seattle, Wash.

Department of Biochemistry, University of Washington and King County Blood Bank, Seattle, Wash.

†

Postdoctoral Fellow of the National Heart Institute, U. S. Public Health Service. Present address: Department of Pharmacology, Yale University School of Medicine, New Haven, Conn.

‡

Special Fellow of the National Cancer Institute, U. S. Public Health Service. Present address: Department of Medicine, New York University, N. Y., N. Y.

§

Present address: Division of Biochemistry, Scripps Clinic and Research Foundation, La Jolla, Calif.

*

This work was supported in part by U. S. Public Health Service grants CYP-4252 and OG-13, and by American Cancer Society grant P-203. Part of this work was presented elsewhere in preliminary form (1).

Find articles by Huennekens, F. in: PubMed | Google Scholar

Published April 1, 1963 - More info

Published in Volume 42, Issue 4 on April 1, 1963
J Clin Invest. 1963;42(4):466–475. https://doi.org/10.1172/JCI104735.
© 1963 The American Society for Clinical Investigation
Published April 1, 1963 - Version history
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