Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Journal stats
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • ASCI Milestone Awards
    • Video Abstracts
    • Conversations with Giants in Medicine
  • Reviews
    • View all reviews ...
    • Emerging therapeutic strategies in breast cancer (Oct 2026)
    • The cGAS-STING pathway: DNA sensing in health and disease (Jun 2026)
    • Neurodegeneration (Mar 2026)
    • Clinical innovation and scientific progress in GLP-1 medicine (Nov 2025)
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • ASCI Milestone Awards
  • Video Abstracts
  • Conversations with Giants in Medicine
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Journal stats
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI104065

THE PHYSIOLOGICAL SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION. III. EVIDENCE FOR A DIRECT IMMEDIATE EFFECT OF INSULIN ON THE BALANCE OF GLUCOSE ACROSS THE LIVER

Leonard L. Madison, Burton Combes, Reuben Adams, and William Strickland

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas

‡

Established Investigator of The American Heart Association.

*

This work was supported in part by a grant from the Upjohn Company and in part by the Dallas Heart Association.

†

Presented in part before the Metabolism Section of the American Society for Clinical Investigation, Atlantic City, May 3, 1959, and at the Symposium on Insulin and Oral Hypoglycemic Agents held at the Indiana University Medical Center, Indianapolis, February 27 and 28, 1959.

Find articles by Madison, L. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas

‡

Established Investigator of The American Heart Association.

*

This work was supported in part by a grant from the Upjohn Company and in part by the Dallas Heart Association.

†

Presented in part before the Metabolism Section of the American Society for Clinical Investigation, Atlantic City, May 3, 1959, and at the Symposium on Insulin and Oral Hypoglycemic Agents held at the Indiana University Medical Center, Indianapolis, February 27 and 28, 1959.

Find articles by Combes, B. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas

‡

Established Investigator of The American Heart Association.

*

This work was supported in part by a grant from the Upjohn Company and in part by the Dallas Heart Association.

†

Presented in part before the Metabolism Section of the American Society for Clinical Investigation, Atlantic City, May 3, 1959, and at the Symposium on Insulin and Oral Hypoglycemic Agents held at the Indiana University Medical Center, Indianapolis, February 27 and 28, 1959.

Find articles by Adams, R. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School, Dallas, Texas

Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas

‡

Established Investigator of The American Heart Association.

*

This work was supported in part by a grant from the Upjohn Company and in part by the Dallas Heart Association.

†

Presented in part before the Metabolism Section of the American Society for Clinical Investigation, Atlantic City, May 3, 1959, and at the Symposium on Insulin and Oral Hypoglycemic Agents held at the Indiana University Medical Center, Indianapolis, February 27 and 28, 1959.

Find articles by Strickland, W. in: PubMed | Google Scholar

Published March 1, 1960 - More info

Published in Volume 39, Issue 3 on March 1, 1960
J Clin Invest. 1960;39(3):507–522. https://doi.org/10.1172/JCI104065.
© 1960 The American Society for Clinical Investigation
Published March 1, 1960 - Version history
View PDF
Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 507
page 507
icon of scanned page 508
page 508
icon of scanned page 509
page 509
icon of scanned page 510
page 510
icon of scanned page 511
page 511
icon of scanned page 512
page 512
icon of scanned page 513
page 513
icon of scanned page 514
page 514
icon of scanned page 515
page 515
icon of scanned page 516
page 516
icon of scanned page 517
page 517
icon of scanned page 518
page 518
icon of scanned page 519
page 519
icon of scanned page 520
page 520
icon of scanned page 521
page 521
icon of scanned page 522
page 522
Version history
  • Version 1 (March 1, 1960): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts