On diabetes: insulin resistance

Series edited by Alan R. Saltiel

Type 2 diabetes is a progressive disease that starts with peripheral insulin resistance, which in itself is a key feature of other human disease states. The series outlines the complex pathophysiology of insulin resistance, including the connections to obesity and cardiovascular disease.

Published January 2000

Nucleic acid therapeutics

Series edited by Bruce Sullenger

The series provides an update on progress in the field of nucleic acid-based therapeutics. Individual articles explore a number of strategies that exploit different facets of DNA and RNA biochemistry towards the development of safe and effective therapeutics.

Published January 2000

Epigenetic regulation

Series edited by Benjamin Tycko

Epigenetic effects are changes in the genetic material that alter gene expression in a manner that is heritable during somatic cell divisions but nonmutational and therefore fundamentally reversible. The articles consider the consequences of epigenetic changes for human disease phenotypes.

Published January 2000

Cancer biotherapy

Series edited by David Kirn

The series reviews the emerging field of tumor-targeted microbes, which offer great potential for antitumoral potency and selective targeting of cancer cells and act by mechanisms not subject to cross-resistance when combined with standard therapies.

Published January 2000

Stem cell biology

Series edited by Pamela Robey

The series reviews the broad array of stem cell types and stimulate discussion of the controversies and challenges that face the field. The articles suggest that a new conceptual framework is needed for thinking about stem cells and their therapeutic potential.

Published January 2000

Tissue responses to ischemia

Series edited by Gregg L. Semenza

Ischemia arises when demands for energy substrates (primarily oxygen and glucose) are not matched by supply. The consequences differ depending on the affected tissue, and the series covers the effects of ischemia in a number of different tissues and organs.

Published January 2000

Targets for cancer therapy

Series edited by William G. Kaelin, Jr.

The series reviews a number of cellular processes that provide cancer drug targets, including angiogenesis, cell cycle and checkpoint control, growth factor signaling, and apoptosis. It also discusses target selection based on genomics and the specific case of the Abl inhibitor Gleevec.

Published December 1999

Alzheimer's disease

Series edited by Sangram Sisodia

Articles in the series highlight recent advances pertaining to the accuracy of clinico-pathological diagnoses, genetic risk factors, mechanisms of disease, and therapeutic strategies, and point to areas for future investigations.

Published November 1999

Asthma

Series edited by Jack A. Elias

The series summarizes recent advances in elucidating the molecular and cellular etiology of asthma. Specific topics covered include the roles of IgE, chemokines, and Th2 cells, as well as early life origins of the disease and airway remodeling seen in patients.

Published October 1999

Angiogenesis

Series edited by David Cheresh

Therapeutic manipulation of angiogenesis would be desirable for the treatment of a variety of diseases, including cancer and heart disease. This short series focuses this therapeutic potential and specifically on integrins and matrix metalloproteinases as potential targets.

Published May 1999