Review Series
113 series available.
Series edited by Henry R. Kranzler
Substance use disorders are characterized by heavy, regular use of one or more psychoactive substances, such as alcohol, nicotine, opioids, cannabis, and stimulants, as well as the development of tolerance and loss of control over use, risk-taking behavior, and physiological dependence. Misuse of psychoactive substances constitutes a growing worldwide burden with broad-ranging health consequences. In this review series, curated by Dr. Henry R. Kranzler, reviews will provide detailed updates on studies of the genetics, biology, and evolving treatment of substance use disorders.
Published October 2024
Series edited by Kenneth Walsh
All cells in the body accumulate somatic mutations over time, but the hematopoietic system is disproportionately affected by driver gene mutations that produce clonal events due to its high rate of turnover. When clonal HSPC expansion is detected in the absence of an overt hematological phenotype, it is referred to as clonal hematopoiesis. This collection of reviews, curated by series editor Kenneth Walsh, will explore factors that drive clonal hematopoiesis, including stress, aging, and cancer therapies. Other reviews will unpack the links between clonal hematopoiesis and disease.
Published October 2024
Series edited by Barbara Stranger
Biological sex profoundly influences disease risk, pathogenesis, progression, and treatment, but there are persistent gaps in the study of sex differences that span all areas of medicine. Reviews in this series will examine sex as a biological variable in cancer, metabolism, cardiovascular disease, autoimmunity, and more and highlight the potential to leverage these sex differences to optimize therapies for all.
Published September 2024
Series edited by Miikka Vikkula
Vascular malformations in arteries, veins, and lymphatic vessels occur in a broad range of conditions that vary widely in severity and presentation. Leveraging the mechanisms specific to each type of malformation will be essential for optimizing disease management. This review series, developed with series editor Miikka Vikkula, will span hemangioma, hereditary hemorrhagic telangiectasia, lymphatic abnormalities, cerebral small vessel disease, capillary malformations, and more, with reviews contributed by leading experts in each condition.
Published April 2024
Series edited by Susanne Herold
The lungs are regularly exposed to airborne irritants, pathogens, and other sources of inflammation that cause injury to the lung epithelium and its underlying structure. Repair and regeneration are essential for healthy lung function throughout life, yet these processes can also influence development and progression of acute and chronic conditions. Series editor Suzanne Herold developed this review series on lung inflammatory injury and tissue repair to reveal the many cell populations involved in normal and aberrant reparative responses. Ranging from discussion of lung stroma and vasculature to adaptive and innate immune systems, the reviews in this series describe the many complex mechanisms that influence pathogen-, inflammation-, and aging-driven injury to the lung and can contribute to aberrant healing, resolution of inflammation, and fibrosis. Reviews also discuss a wide range of potential therapies targeting injury and repair processes that represent promising progress toward better clinical options for patients with acute and chronic lung conditions.
Published July 2023
Series edited by Amy B Heimberger and Daniel J. Brat and Maciej S. Lesniak
Glioblastomas are high-grade and aggressive CNS tumors. Due to heterogeneous composition, rapid growth, and suppressive immune microenvironment, gliomablastomas remain difficult to successfully treat. JCI editors Amy Heimberger, Daniel Brat, and Maciej Lesniak curated the reviews in this issue’s series to confront the many aspects of immune involvement in these clinically challenging tumors. Reviews in this series describe how tumor-associated macrophages, microglia, and neutrophils modulate glioblastoma progression and therapy response. They also explore new concepts for targeting the immune microenvironment in glioblastoma, including strategies targeting immunometabolism or epigenetic regulation, personalized immunotherapy approaches, and next-generation antigen presenting cell-based therapies.
Published February 2023
The Stanley J. Korsmeyer Award recognizes the outstanding achievements of ASCI members in advancing knowledge in a specific field and in mentoring future generations of life science researchers. The recognition, which was first known as the ASCI Award, was renamed in 2006 in honor of Dr. Stanley J. Korsmeyer, a dedicated and accomplished physician-scientist and mentor who was the first recipient in 1998 and who passed away in 2005. 2023 marks the 25th Anniversary of the Korsmeyer Award, and the ASCI and JCI commemorate this milestone with a collection of articles contributed by the award's past winners. Articles will be added to this collection throughout the year.
Published January 2023
Series edited by James L. Kirkland
Aging plays a central role in many chronic diseases affecting all systems of the body. Nine hallmarks of aging have been identified: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This new review series on Aging closely examines how these hallmarks contribute to the initiation and progression of disease. Curated by series editor Dr. James Kirkland, topics span aging’s role in immune system function, cancer, cognitive decline and neurodegenerative disease, and metabolism. The reviews also discuss the latest developments in senotherapeutic strategies that destroy senescent cells, reverse senescence, or target specific aging hallmarks with a critical eye.
Published July 2022
Series edited by Ben Ho Park
Next-generation sequencing (NGS) technology enables rapid, high-throughput sequencing of thousands of genes or even entire genomes. The speed and scale of these techniques makes them powerful tools in medicine, creating an opportunity to build and search deep genetic databases, refine diagnoses, and inform precision medicine approaches. In this series, designed by Ben H. Park, five reviews describe how NGS is revolutionizing clinical insights into disease. Wensel et al. compare key NGS methods for investigating the microbiome, emphasizing the need for careful study design and validation as these techniques become more widely adopted. Schuler et al. outline the capabilities and limitations of current genetic testing approaches and provide examples of clinical scenarios in which NGS was combined with other strategies to make a diagnosis. The contribution from Waarts et al. describes how NGS has contributed to the identification of targetable mutations in a range of cancers and discusses challenges to achieving maximal therapeutic benefit of targeted treatments. Halima et al. focus on high-throughput NGS approaches that are revealing the fundamental genetic processes that govern immunity, influencing how we design and implement cancer immunotherapy. Finally, Dang and Park’s review on circulating tumor DNA discusses the advantages of blood-based diagnosis as well as strategies to overcome technical limitations and improve detection of cancer in its earliest stages.
Published June 2022
Series edited by Daniel P. Kelly
Cardiovascular diseases remain a leading cause of death worldwide, and treatment is complicated by the inadequacies of available therapies. This collection of reviews, developed by Daniel P. Kelly, explores emerging strategies for treating a range of cardiac pathologies, including: recent discoveries of epigenetic regulators that can be targeted to combat cardiac fibrosis, state of the art in genome-editing therapies, interactions of the vascular endothelium with metabolic tissues, current understanding of myosin modulators, and novel targets for treating dyslipidemia. Together, the reviews provide a broad update on numerous advances in cardiovascular medicine.
Published March 2022
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ISSN: 0021-9738 (print), 1558-8238 (online)