Citations to this article
Citation Information: J Clin Invest. 2017;127(7):2523-2529. https://doi.org/10.1172/JCI90601.
Abstract
An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal disease, this therapy has not been optimized for older patients because of our lack of understanding of the effect of aging and the immune response to organ transplantation. Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. We describe what has been determined to date, discuss existing gaps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantation for older people.
Authors
Monica M. Colvin, Candice A. Smith, Stefan G. Tullius, Daniel R. Goldstein
Total citations by year
Citations to this article in year 2023 (6)
| Title and authors | Publication | Year |
|---|---|---|
|
The aging of the immune system and its implications for transplantation
McGovern KE, Sonar SA, Watanabe M, Coplen CP, Bradshaw CM, Nikolich JŽ |
GeroScience | 2023 |
|
The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging
Hannah Fitzgerald, Jesse Bonin, Sudeshna Sadhu, Masharh Lipscomb, Nirupam Biswas, Christa Decker, Melisande Nabage, Ramon Bossardi, Michael Marinello, Hebe Agustina Mena, Kurrim Gilliard, Matthew Spite, Alejandro Adam, Katherine MacNamara, Gabrielle Fredman |
The American Journal of Pathology | 2023 |
|
Age associations with tacrolimus and mycophenolic acid pharmacokinetics in stable Black and White kidney transplant recipients: Implications for health inequities
Tornatore KM, Attwood K, Venuto RC, Murray B |
Clinical and Translational Science | 2023 |
|
Can We Predict Graft Intolerance Syndrome After Kidney Transplant Failure? External Validation of a Previously Developed Model
Bunthof K, Saboerali K, Wetering JV, Nurmohamed A, Bemelman F, Zuilen AV, Brand JV, Baas M, Hilbrands L |
Transplant International | 2023 |
|
Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors
Cohen GS, Kallarakal MA, Jayaraman S, Ibukun FI, Tong KP, Orzolek LD, Benjamin Larman H, Krummey SM |
Cell Reports | 2023 |
|
Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs.
Kirchner VA, Badshah JS, Hong SK, Martinez O, Pruett TL, Niedernhofer LJ |
Transplantation | 2023 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)