Go to
JCI Insight
Citations to this article
Monica M. Colvin, … , Stefan G. Tullius, Daniel R. Goldstein
Published May 15, 2017
Citation Information: J Clin Invest. 2017;127(7):2523-2529. https://doi.org/10.1172/JCI90601.
Citation Information: J Clin Invest. 2017;127(7):2523-2529. https://doi.org/10.1172/JCI90601.
Abstract
An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal disease, this therapy has not been optimized for older patients because of our lack of understanding of the effect of aging and the immune response to organ transplantation. Here, we provide an overview of the impact of aging on both the allograft and the recipient and its effect on the immune response to organ transplantation. We describe what has been determined to date, discuss existing gaps in our knowledge, and make suggestions on necessary future studies to optimize organ transplantation for older people.
Authors
Monica M. Colvin, Candice A. Smith, Stefan G. Tullius, Daniel R. Goldstein
Total citations by year
Citation information
Citations to this article (29)
| Title and authors | Publication | Year |
|---|---|---|
|
The Potential of Neonatal Organ Donation in Central Sweden
Bluhme E, Henckel E, Hallberg B, Jorns C |
Cell Transplantation | 2025 |
|
Characteristics of mismatched eplets affecting de novo donor-specific antibody production and antibody-mediated rejection after kidney transplantation
Li MH, Zhou GX, Lan P, Li YX, Zhang X, Kuang PD, Zhang Y, Wang Y, Zhang MY, Ding XM, Xue WJ, Zheng J |
BMC Nephrology | 2025 |
|
Immunometabolism of Liver Xenotransplantation and Prospective Solutions
Deng S, Zhang Y, Shen S, Li C, Qin C |
Advanced Science | 2025 |
|
Low dose post-transplant cyclophosphamide and sirolimus induce mixed chimerism with CTLA4-Ig or lymphocyte depletion in an MHC-mismatched murine allotransplantation model.
Kabore MD, McElrath CC, Ali MAE, Almengo K, Gangaplara A, Fisher C, Barreto MA, Shaikh A, Olkhanud PB, Xu X, Gaskin D, Lopez-Ocasio M, Saxena A, McCoy JP, Fitzhugh CD |
Bone Marrow Transplantation | 2024 |
|
Editorial: Immunosenescence in organ transplantation
Iske J, Zhou H |
2024 | |
|
Older age is associated with a distinct and marked reduction of functionality of both alloreactive CD4+ and CD8+ T cells
Litjens NH, van der List AC, Klepper M, Reijerkerk D, Prevoo F, Betjes MG |
Frontiers in immunology | 2024 |
|
Pretransplant Cognitive Function and Kidney Transplant Outcomes: A Prospective Cohort Study
Gupta A, Grasing MJ, Young KJ, Montgomery RN, Murillo DJ, Cibrik DM |
Kidney Medicine | 2024 |
|
The aging of the immune system and its implications for transplantation
McGovern KE, Sonar SA, Watanabe M, Coplen CP, Bradshaw CM, Nikolich JŽ |
GeroScience | 2023 |
|
The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging
Hannah Fitzgerald, Jesse Bonin, Sudeshna Sadhu, Masharh Lipscomb, Nirupam Biswas, Christa Decker, Melisande Nabage, Ramon Bossardi, Michael Marinello, Hebe Agustina Mena, Kurrim Gilliard, Matthew Spite, Alejandro Adam, Katherine MacNamara, Gabrielle Fredman |
The American Journal of Pathology | 2023 |
|
Age associations with tacrolimus and mycophenolic acid pharmacokinetics in stable Black and White kidney transplant recipients: Implications for health inequities
Tornatore KM, Attwood K, Venuto RC, Murray B |
Clinical and Translational Science | 2023 |
|
Can We Predict Graft Intolerance Syndrome After Kidney Transplant Failure? External Validation of a Previously Developed Model
Bunthof K, Saboerali K, Wetering JV, Nurmohamed A, Bemelman F, Zuilen AV, Brand JV, Baas M, Hilbrands L |
Transplant International | 2023 |
|
Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors
Cohen GS, Kallarakal MA, Jayaraman S, Ibukun FI, Tong KP, Orzolek LD, Benjamin Larman H, Krummey SM |
Cell Reports | 2023 |
|
Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs.
Kirchner VA, Badshah JS, Hong SK, Martinez O, Pruett TL, Niedernhofer LJ |
Transplantation | 2023 |
|
Predictors of Serological Response to SARS-CoV-2 Vaccination in Kidney Transplant Patients: Baseline Characteristics, Immunosuppression, and the Role of IMPDH Monitoring
L Liefeldt, P Glander, J Klotsche, H Straub-Hohenbleicher, K Budde, B Eberspächer, F Friedersdorff, F Halleck, P Hambach, J Hofmann, N Koch, D Schmidt, E Schrezenmeier, E Seelow, U Weber, B Zukunft, K Eckardt, M Choi, F Bachmann, J Waiser |
Journal of Clinical Medicine | 2022 |
|
Are older adults safe and suitable candidate donors or recipients for kidney transplantation?
Hong YA |
Kidney Research and Clinical Practice | 2022 |
|
Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)
Jeong JC, Koo TY, Ro H, Lee DR, Lee DW, Oh J, Kim J, Chae DW, Kim YH, Huh KH, Park JB, Kim YH, Han S, Choi SJ, Lee S, Min SI, Ha J, Kim MS, Ahn C, Yang J |
Scientific Reports | 2022 |
|
Absence of TSC1 Accelerates CD8+ T cell-mediated Acute Cardiac Allograft Rejection
Tan L, Xu Y, Lan G, Wang H, Liang Z, Zhang Z, Tian Q, Hou Y, Zhao Y, Xie X |
Aging and disease | 2022 |
|
Assessment of human leukocyte antigen matching algorithm PIRCHE‐II on liver transplantation outcomes
Kok G, Verstegen MM, Houwen RH, Nieuwenhuis EE, Metselaar HJ, Polak WG, van der Laan LJ, Spierings E, den Hoed CM, Fuchs SA |
Liver Transplantation | 2022 |
|
Aging, cancer, and antitumor immunity
H Ikeda, Y Togashi |
International Journal of Clinical Oncology | 2021 |
|
Targeting age‐specific changes in CD4 + T cell metabolism ameliorates alloimmune responses and prolongs graft survival
Y Nian, J Iske, R Maenosono, K Minami, T Heinbokel, M Quante, Y Liu, H Azuma, J Yang, R Abdi, H Zhou, A Elkhal, SG Tullius |
Aging Cell | 2021 |
|
Ageing of Immune System and Response to a Live-Attenuated Herpes Zoster Vaccine in Lung Transplant Candidates
L Wang, EA Verschuuren, D Paap, C Rondaan, E Raveling-Eelsing, S Liu, J Westra, NA Bos |
Human vaccines | 2021 |
|
Immunosuppression Considerations for Older Kidney Transplant Recipients
W Cheungpasitporn, KL Lentine, JC Tan, M Kaufmann, Y Caliskan, S Bunnapradist, NN Lam, M Schnitzler, DA Axelrod |
Current Transplantation Reports | 2021 |
|
Transplant of Elderly Patients
C Cottone, NA Polanco, KR Bhamidimarri |
Clinics in Liver Disease | 2021 |
|
Recipient efficacy and safety of kidney transplantation from older living donor: consideration for using older kidney as a solution to the shortage of organs
Song JY, Lee KW, Kim K, Kim KD, Yang J, Kwon JE, Lee O, Park JB |
2021 | |
|
Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19
J Chen, WJ Kelley, DR Goldstein |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
|
Unfavorable Contribution of a Tissue-Engineering Cartilage Graft to Osteochondral Defect Repair in Young Rabbits
Z Lu, S Zhou, J Vaida, G Gao, A Stewart, J Parenti, L Yan, M Pei |
Frontiers in Cell and Developmental Biology | 2020 |
|
Age-associated decrease in de novo donor-specific antibodies in renal transplant recipients reflects changing humoral immunity
S von Moos, G Schalk, TF Mueller, G Laube |
Immunity & Ageing | 2019 |
|
Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry
OK Jawitz, V Raman, J Klapper, M Hartwig, CB Patel, C Milano |
Transplant International | 2019 |
|
Biomarkers in solid organ transplantation
T van Gelder |
British Journal of Clinical Pharmacology | 2017 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)