Go to
JCI Insight
Citations to this article
Thomas Vogl, … , Thomas Pap, Johannes Roth
Published April 3, 2018
Citation Information: J Clin Invest. 2018;128(5):1852-1866. https://doi.org/10.1172/JCI89867.
Citation Information: J Clin Invest. 2018;128(5):1852-1866. https://doi.org/10.1172/JCI89867.
Abstract
Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DAMPs), are indispensable for manifestation of local inflammation. S100A8/S100A9 complexes are the most abundant DAMPs in many autoimmune diseases. However, regulatory mechanisms locally restricting DAMP activities are barely understood. We now unravel for the first time, to our knowledge, a mechanism of autoinhibition in mice and humans restricting S100-DAMP activity to local sites of inflammation. Combining protease degradation, pull-down assays, mass spectrometry, and targeted mutations, we identified specific peptide sequences within the second calcium-binding EF-hands triggering TLR4/MD2-dependent inflammation. These binding sites are free when S100A8/S100A9 heterodimers are released at sites of inflammation. Subsequently, S100A8/S100A9 activities are locally restricted by calcium-induced (S100A8/S100A9)2 tetramer formation hiding the TLR4/MD2-binding site within the tetramer interphase, thus preventing undesirable systemic effects. Loss of this autoinhibitory mechanism in vivo results in TNF-α–driven fatal inflammation, as shown by lack of tetramer formation in crossing S100A9–/– mice with 2 independent TNF-α–transgene mouse strains. Since S100A8/S100A9 is the most abundant DAMP in many inflammatory diseases, specifically blocking the TLR4-binding site of active S100 dimers may represent a promising approach for local suppression of inflammatory diseases, avoiding systemic side effects.
Authors
Thomas Vogl, Athanasios Stratis, Viktor Wixler, Tom Völler, Sumita Thurainayagam, Selina K. Jorch, Stefanie Zenker, Alena Dreiling, Deblina Chakraborty, Mareike Fröhling, Peter Paruzel, Corinna Wehmeyer, Sven Hermann, Olympia Papantonopoulou, Christiane Geyer, Karin Loser, Michael Schäfers, Stephan Ludwig, Monika Stoll, Tomas Leanderson, Joachim L. Schultze, Simone König, Thomas Pap, Johannes Roth
Total citations by year
Citation information
Citations to this article (119)
| Title and authors | Publication | Year |
|---|---|---|
|
Roles of the Receptor for Advanced Glycation End Products and Its Ligands in the Pathogenesis of Alzheimer’s Disease
Li W, Chen Q, Peng C, Yang D, Liu S, Lv Y, Jiang L, Xu S, Huang L |
International Journal of Molecular Sciences | 2025 |
|
RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8
Ran X, Li Y, Ren Y, Chang W, Deng R, Wang H, Zhu W, Zhang Y, Cai Y, Hu J, Wang D, Liu Z |
Cell Death & Disease | 2025 |
|
The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA
Leib L, Juli J, Jurida L, Mayr-Buro C, Priester J, Weiser H, Wirth S, Hanel S, Heylmann D, Weber A, Schmitz ML, Papantonis A, Bartkuhn M, Wilhelm J, Linne U, Meier-Soelch J, Kracht M |
EMBO Reports | 2025 |
|
Unmet needs and research gaps in Still’s disease across ages: proceedings from a pediatric and adult joint expert panel
Bracaglia C, Minoia F, Vastert SJ, Kessel C, Dagna L, Ravelli A, De Benedetti F |
Pediatric Rheumatology | 2025 |
|
S100A8/A9 high-expression macrophages mediate renal tubular epithelial cell damage in acute kidney injury following acute type A aortic dissection surgery
Cai X, Li X, Shi J, Tang L, Yang J, Yu R, Wang Z, Wang D |
Frontiers in Molecular Biosciences | 2025 |
|
S100A9 as a promising therapeutic target for diabetic foot ulcers
Wan R, Fang S, Zhang X, Zhou W, Bi X, Yuan L, Lv Q, Song Y, Tang W, Shi Y, Li T |
Chinese Medical Journal | 2025 |
|
Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses’ Health Study II
Sasamoto N, Ngo LH, Vitonis AF, Dillon ST, Aziz M, Shafrir AL, Missmer SA, Libermann TA, Terry KL |
eBioMedicine | 2025 |
|
Chronic skin and systemic inflammation modulated by S100A8 and S100A9 complexes.
Palomo-Irigoyen M, Bakiri L, Hendrikx T, Hayer S, Schaffenrath J, Widder S, Bachg S, Simmons J, Gallo RL, Starkl P, Roth J, Wagner EF |
Cell death and differentiation | 2025 |
|
S100A9 exerts insulin-independent antidiabetic and anti-inflammatory effects.
Ursino G, Lucibello G, Teixeira PDS, Höfler A, Veyrat-Durebex C, Odouard S, Visentin F, Galgano L, Somm E, Vianna CR, Widmer A, Jornayvaz FR, Boland A, Ramadori G, Coppari R |
Science Advances | 2024 |
|
The pyrin inflammasome, a leading actor in pediatric autoinflammatory diseases
La Bella S, Di Ludovico A, Di Donato G, Basaran O, Ozen S, Gattorno M, Chiarelli F, Breda L |
Frontiers in immunology | 2024 |
|
Current understanding of macrophages in intracranial aneurysm: relevant etiological manifestations, signaling modulation and therapeutic strategies
Duan J, Zhao Q, He Z, Tang S, Duan J, Xing W |
Frontiers in immunology | 2024 |
|
Lack of Elevated Expression of TGFβ3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas.
Gao N, Yu FS |
Investigative ophthalmology & visual science | 2024 |
|
Effect of acute inflammatory reaction induced by biopsy on tumor microenvironment.
Chen Y, Liu H, Sun Y |
Journal of Cancer Research and Clinical Oncology | 2024 |
|
Computational inhibition of S100A8 (calgranulin A) as a potential non-invasive biomarker for rheumatoid arthritis
Choudhury K, Khadanga A, Purty RS |
In Silico Pharmacology | 2024 |
|
S100A9 as a Key Myocardial Injury Factor Interacting with ATP5 Exacerbates Mitochondrial Dysfunction and Oxidative Stress in Sepsis-Induced Cardiomyopathy
Pei H, Qu J, Chen J, Zhao G, Lu Z |
Journal of inflammation research | 2024 |
|
Advances in the study of S100A9 in cardiovascular diseases
Chen F, He Z, Wang C, Si J, Chen Z, Guo Y |
Cell Proliferation | 2024 |
|
Evaluation of neutrophil activation marker in patients with vitiligo.
El-Sadek HM, Elmadbouly AA, Risha BEM |
Irish journal of medical science | 2024 |
|
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling.
Özbay Kurt FG, Cicortas BA, Balzasch BM, De la Torre C, Ast V, Tavukcuoglu E, Ak C, Wohlfeil SA, Cerwenka A, Utikal J, Umansky V |
Journal for immunotherapy of cancer | 2024 |
|
Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds
Franz S, Torregrossa M, Anderegg U, Ertel A, Saalbach A |
International Journal of Molecular Sciences | 2024 |
|
FPR1 signaling aberrantly regulates S100A8/A9 production by CD14+FCN1hi macrophages and aggravates pulmonary pathology in severe COVID-19
Wang Z, Wang Y, Yan Q, Cai C, Feng Y, Huang Q, Li T, Yuan S, Huang J, Luo ZH, Zhou J |
Communications Biology | 2024 |
|
Blocking S100A9-signaling is detrimental to the initiation of anti-tumor immunity.
Demir MF, Lin YH, Costa Cruz PH, Tajima M, Honjo T, Müller E |
Frontiers in immunology | 2024 |
|
Endogenous Ligands of TLR4 in Microglia: Potential Targets for Related Neurological Diseases.
Chen B, Di B |
Current drug targets | 2024 |
|
Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
Napoli M, Immler R, Rohwedder I, Lupperger V, Pfabe J, Gonzalez Pisfil M, Yevtushenko A, Vogl T, Roth J, Salvermoser M, Dietzel S, Slak Rupnik M, Marr C, Walzog B, Sperandio M, Pruenster M |
eLife | 2024 |
|
Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis
Van Espen B, Prideaux EB, Wilson AR, Machado CR, Sendo S, Parker J, Seumois G, Sacchetti C, Belongia AC, Perumal NB, Vijayanand P, Linnik MD, Benschop RJ, Wang W, Bottini N, Firestein GS, Stanford SM |
Arthritis & rheumatology (Hoboken, N.J.) | 2024 |
|
S100A9 is indispensable for survival of pneumococcal pneumonia in mice
Lena Ostermann, Benjamin Seeliger, Sascha David, Carolin Flasche, Regina Maus, Marieke S. Reinboth, Martin Christmann, Konstantin Neumann, Korbinian Brand, Stephan Seltmann, Frank Bühling, James Paton, Johannes Roth, Thomas Vogl, Dorothee Viemann, Tobias Welte, Ulrich Maus |
PLoS pathogens | 2023 |
|
Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DA, Wanderley CW, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PC, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz\u2010Junior CM, Santos FR, de Souza FR, Costa VV, Barroso SP, Morrot A, Van Weyenbergh J, Sordi R, Alisson\u2010Silva F, Cunha FQ, Rocha EL, Chollet\u2010Martin S, Hurtado\u2010Nedelec MM, Martin C, Burgel P, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko\u2010Sarsat V, Spiller F |
British Journal of Pharmacology | 2023 |
|
S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of Leukocytes
Wolf M, Joseph R, Austermann J, Scharrnbeck-Davis C, Hermann S, Roth J, Vogl T |
Biomedicines | 2023 |
|
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling
Sun Y, Nascimento Da Conceicao V, Chauhan A, Sukumaran P, Chauhan P, Ambrus JL, Vissink A, Kroese FG, Muniswamy M, Mishra BB, Singh BB |
Clinical and Translational Medicine | 2023 |
|
Novel mechanisms of thrombo-inflammation during infection: spotlight on neutrophil extracellular trap-mediated platelet activation
Colicchia M, Perrella G, Gant P, Rayes J |
Research and Practice in Thrombosis and Haemostasis | 2023 |
|
The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9
Möller A, Jauch-Speer SL, Gandhi S, Vogl T, Roth J, Fehler O |
Frontiers in immunology | 2023 |
|
S100A8 and S100A9 are associated with endometrial shedding during menstruation.
Arai K, Kubota A, Iwasaki T, Sonoda A, Sakane J |
Medical Molecular Morphology | 2023 |
|
Toward an understanding of the conformational plasticity of S100A8 and S100A9 Ca2+-binding proteins
Polakowska M, Steczkiewicz K, Szczepanowski RH, Wysłouch-Cieszyńska A |
The Journal of biological chemistry | 2023 |
|
Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis
Zhou L, Yan Z, Yang W, Buckley JA, Al Diffalha S, Benveniste EN, Qin H |
Frontiers in immunology | 2023 |
|
Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice
Deshmukh M, Subhash S, Hu Z, Mohammad M, Jarneborn A, Pullerits R, Jin T, Kopparapu PK |
Frontiers in microbiology | 2023 |
|
Role of neutrophils in different stages of atherosclerosis.
Zhang X, Kang Z, Yin D, Gao J |
Innate immunity | 2023 |
|
When to stop medication in juvenile idiopathic arthritis
Abel D, Weiss PF |
Current Opinion in Rheumatology | 2023 |
|
S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
Saito-Sasaki N, Sawada Y |
Diagnostics | 2023 |
|
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models.
Cho E, Mun SJ, Kim HK, Ham YS, Gil WJ, Yang CS |
Acta Pharmacologica Sinica | 2023 |
|
Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis
Bartels YL, van Lent PL, van der Kraan PM, Blom AB, Bonger KM, van den Bosch MH |
Rheumatology (Oxford, England) | 2023 |
|
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing
S Franz, A Ertel, K Engel, J Simon, A Saalbach |
Theranostics | 2022 |
|
S100A9 blockade improves the functional recovery after spinal cord injury via mediating neutrophil infiltration
F Sun, H Zhang, T Huang, J Shi, T Wei, Y Wang |
Experimental and therapeutic medicine | 2022 |
|
Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin
L Rochette, G Dogon, E Rigal, M Zeller, Y Cottin, C Vergely |
Cells | 2022 |
|
S100A9 is a functional effector of infarct wall thinning after myocardial infarction
U Chalise, M Becirovic-Agic, M nd, S Konfrst, J Rodriguez-Paar, D Feng, J Salomon, D Anderson, L Cook, M Lindsey |
American journal of physiology. Heart and circulatory physiology | 2022 |
|
S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation
E Sprenkeler, J Zandstra, N van Kleef, I Goetschalckx, B Verstegen, C Aarts, H Janssen, A Tool, G van Mierlo, R van Bruggen, I Jongerius, T Kuijpers |
Cells | 2022 |
|
Regulation of zinc-dependent enzymes by metal carrier proteins
M Thompson |
BioMetals | 2022 |
|
A Structural Perspective on Calprotectin as a Ligand of Receptors Mediating Inflammation and Potential Drug Target
V Garcia, Y Perera, W Chazin |
Biomolecules | 2022 |
|
C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9
S Jauch-Speer, M Herrera-Rivero, N Ludwig, B Carvalho, L Martens, J Wolf, A Chasan, A Witten, B Markus, B Schieffer, T Vogl, J Rossaint, M Stoll, J Roth, O Fehler |
eLife | 2022 |
|
Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?
Valdrighi N, Vago JP, Blom AB, van de Loo FA, Blaney Davidson EN |
Frontiers in pharmacology | 2022 |
|
The Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation
Austermann J, Roth J, Barczyk-Kahlert K |
Cells | 2022 |
|
Gut Bacterial Isoamylamine Promotes Age-Related Cognitive Dysfunction by Promoting Microglial Cell Death
Teng Y, Mu J, Xu F, Zhang X, Sriwastva MK, Liu QM, Li X, Lei C, Sundaram K, Hu X, Zhang L, Park JW, Hwang JY, Rouchka EC, Zhang X, Yan J, Merchant ML, Zhang HG |
Cell Host & Microbe | 2022 |
|
Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis
Ursino G, Ramadori G, Höfler A, Odouard S, Teixeira PD, Visentin F, Veyrat-Durebex C, Lucibello G, Firnkes R, Ricci S, Vianna CR, Jia L, Dirlewanger M, Klee P, Elmquist JK, Roth J, Vogl T, Schwitzgebel VM, Jornayvaz FR, Boland A, Coppari R |
Nature Communications | 2022 |
|
Multifunctional Role of S100 Protein Family in the Immune System: An Update
Singh P, Ali SA |
Cells | 2022 |
|
Insights into innate immune activation via PS-ASO–protein–TLR9 interactions
Pollak AJ, Zhao L, Vickers TA, Huggins IJ, Liang XH, Crooke ST |
Nucleic Acids Research | 2022 |
|
Antimicrobial peptides: Defending the mucosal epithelial barrier
Johnstone KF, Herzberg MC |
2022 | |
|
Use of MRP8/14 in clinical practice as a predictor of outcome after methotrexate withdrawal in patients with juvenile idiopathic arthritis
Sumner EJ, Almeida B, Palman J, Bale P, Heard C, Holzinger D, Roth J, Foell D, Robinson E, Ursu S, Wallace C, Gilmour K, Wedderburn LR, Ralph E |
Clinical Rheumatology | 2022 |
|
Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease
Mellor LF, Gago-Lopez N, Bakiri L, Schmidt FN, Busse B, Rauber S, Jimenez M, Megías D, Oterino-Sogo S, Sanchez-Prieto R, Grivennikov S, Pu X, Oxford J, Ramming A, Schett G, Wagner EF |
Annals of the rheumatic diseases | 2022 |
|
S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
Real F, Zhu A, Huang B, Belmellat A, Sennepin A, Vogl T, Ransy C, Revol M, Arrigucci R, Lombès A, Roth J, Gennaro ML, Bouillaud F, Cristofari S, Bomsel M |
Nature Communications | 2022 |
|
Evolution avoids a pathological stabilizing interaction in the immune protein S100A9
Harman JL, Reardon PN, Costello SM, Warren GD, Phillips SR, Connor PJ, Marqusee S, Harms MJ |
Proceedings of the National Academy of Sciences | 2022 |
|
S100A9‑containing serum exosomes obtained from patients with burn injuries promote myocardial cell pyroptosis through NLRP3
Wang A, Zheng N, Jia Q, Chen Y, Xu S |
Experimental and therapeutic medicine | 2022 |
|
Role of S100A8/A9 in Platelet–Neutrophil Complex Formation during Acute Inflammation
Revenstorff J, Ludwig N, Hilger A, Mersmann S, Lehmann M, Grenzheuser JC, Kardell M, Bone J, Kötting NM, Marx NC, Roth J, Vogl T, Rossaint J |
Cells | 2022 |
|
Circulatory levels of alarmins in patients with non-segmental vitiligo: Potential biomarkers for disease diagnosis and activity/severity assessment
He K, Wu W, Wang X, Dai W, Wang S, Li C, Li S |
Frontiers in immunology | 2022 |
|
A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model.
Ortega-Rivera OA, Shin MD, Moreno-Gonzalez MA, Pokorski JK, Steinmetz NF |
2022 | |
|
Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes
Russo A, Schürmann H, Brandt M, Scholz K, Matos AL, Grill D, Revenstorff J, Rembrink M, von Wulffen M, Fischer\u2010Riepe L, Hanley PJ, Häcker H, Prünster M, Sánchez\u2010Madrid F, Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J |
Advanced Science | 2022 |
|
IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19
Renieris G, Karakike E, Gkavogianni T, Droggiti DE, Stylianakis E, Andriopoulou T, Spanou VM, Kafousopoulos D, Netea MG, Eugen-Olsen J, Simard J, Giamarellos-Bourboulis EJ |
Journal of Innate Immunity | 2022 |
|
Characteristic analysis of skin keratinocytes in patients with type 2 diabetes based on the single-cell levels
Liao B, Ouyang Q, Song H, Wang Z, Ou J, Huang J, Liu L |
Chinese Medical Journal | 2022 |
|
The expanding family of neutrophil-derived extracellular vesicles
Marki A, Ley K |
Immunological Reviews | 2022 |
|
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DA, Wanderley CW, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC, Paula NM, Silva PC, Fonseca FR, Aires L, Heck N, Starick MR, Queiroz-Junior CM, Santos FR, de Souza FR, Costa VV, Barroso SP, Morrot A, Van Weyenbergh J, Sordi R, Alisson-Silva F, Cunha FQ, Rocha EL, Chollet-Martin S, Hurtado-Nedelec MM, Martin C, Burgel PR, Mansur DS, Maurici R, Macauley MS, Báfica A, Witko-Sarsat V, Spiller F |
2022 | |
|
S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development
LM Davison, AA Alberto, HA Dand, EJ Keller, M Patt, A Khan, N Dvorina, A White, N Sakurai, LN Liegl, T Vogl, TN Jorgensen |
Frontiers in immunology | 2021 |
|
Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and proinflammatory immune reprogramming
SJ Denstaedt, AC Bustamante, MW Newstead, BB Moore, TJ Standiford, RL Zemans, BH Singer |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
|
Calprotectin (S100A8/A9) Is an Innate Immune Effector in Experimental Periodontitis
KF Johnstone, Y Wei, PD Bittner-Eddy, GW Vreeman, IA Stone, JB Clayton, CS Reilly, TB Walbon, EN Wright, SL Hoops, WS Boyle, M Costalonga, MC Herzberg, M Whiteley |
Infection and immunity | 2021 |
|
Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia
K Woods, B Guezguez |
Frontiers in Cell and Developmental Biology | 2021 |
|
Screening of key biomarkers and immune infiltration in Pulmonary Arterial Hypertension via integrated bioinformatics analysis
Y Zeng, N Li, Z Zheng, R Chen, W Liu, J Cheng, J Zhu, M Zeng, M Peng, C Hong |
Bioengineered | 2021 |
|
Discerning the promising binding sites of S100/calgranulins and their therapeutic potential in atherosclerosis
H Singh, V Rai, DK Agrawal |
Expert Opinion on Therapeutic Patents | 2021 |
|
Role of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors
Y Zhou, J Hann, V Schenten, S Plançon, JL Bueb, F Tolle, S Bréchard |
International journal of molecular sciences | 2021 |
|
Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
AC Mihaila, L Ciortan, RD Macarie, M Vadana, S Cecoltan, MB Preda, A Hudita, AM Gan, G Jakobsson, MM Tucureanu, E Barbu, S Balanescu, M Simionescu, A Schiopu, E Butoi |
Frontiers in immunology | 2021 |
|
Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis
M Shankar, N Uwamahoro, E Backman, S Holmberg, MJ Niemiec, J Roth, T Vogl, CF Urban |
Frontiers in immunology | 2021 |
|
Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes
C Christmann, S Zenker, L Martens, J Hübner, K Loser, T Vogl, J Roth |
Frontiers in immunology | 2021 |
|
Calprotectin: from biomarker to biological function
A Jukic, L Bakiri, EF Wagner, H Tilg, TE Adolph |
Gut | 2021 |
|
Development of anti-thrombotic vaccine against human S100A9 in rhesus monkey
M Shimamura, K Kaikita, H Nakagami, T Kawano, N Ju, H Hayashi, R Nakamaru, S Yoshida, T Sasaki, H Mochizuki, K Tsujita, R Morishita |
Scientific Reports | 2021 |
|
S100A8/A9 is not essential for the development of inflammation and joint pathology in interleukin-1 receptor antagonist knockout mice
ID Ceglie, PL van Lent, EJ Geven, MI Koenders, AB Blom, T Vogl, J Roth, MH van den Bosch |
Arthritis Research & Therapy | 2021 |
|
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
NB Leimkühler, HF Gleitz, L Ronghui, IA Snoeren, SN Fuchs, JS Nagai, B Banjanin, KH Lam, T Vogl, C Kuppe, US Stalmann, G Büsche, H Kreipe, I Gütgemann, P Krebs, Y Banz, P Boor, EW Tai, TH Brümmendorf, S Koschmieder, M Crysandt, E Bindels, R Kramann, IG Costa, RK Schneider |
Cell Stem Cell | 2021 |
|
Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection
X Wang, G Xu, X Liu, Y Liu, S Zhang, Z Zhang |
Cellular and Molecular Immunology | 2021 |
|
Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
R Loera-Valencia, MA Ismail, J Goikolea, M Lodeiro, L Mateos, I Björkhem, E Puerta, MA Romão, CM Gomes, P Merino-Serrais, S Maioli, A Cedazo-Minguez |
Molecular Neurobiology | 2021 |
|
Molecular Evolution of Transition Metal Bioavailability at the Host–Pathogen Interface
GT Antelo, AJ Vila, DP Giedroc, DA Capdevila |
Trends in Microbiology | 2021 |
|
Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer
S Zhu, AH Ma, Z Zhu, E Adib, T Rao, N Li, K Ni, VC Chittepu, R Prabhala, JG Risco, D Kwiatkowski, K Mouw, G Sonpavde, F Cheng, C Pan |
Journal for ImmunoTherapy of Cancer | 2021 |
|
S100A8 expression in oviduct mucosal epithelial cells is regulated by estrogen and affects mucosal immune homeostasis
X Li, G Cao, H Yang, D Zhi, L Li, D Wang, M Liu, H Su, L Chen |
PloS one | 2021 |
|
Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
M Kasper, M Heming, D Schafflick, X Li, T Lautwein, MM zu Horste, D Bauer, K Walscheid, H Wiendl, K Loser, A Heiligenhaus, GM zu Hörste |
eLife | 2021 |
|
Targeting S100A9 Reduces Neutrophil Recruitment, Inflammation and Lung Damage in Abdominal Sepsis
Z Ding, F Du, RG V, G Jakobsson, CF Rönnow, M Rahman, A Schiopu, H Thorlacius |
International journal of molecular sciences | 2021 |
|
Role of the Alarmin S100A9 protein in inducing Achilles tendinopathy in rats
B Zhao, J Li, C Xue, J Li, H Ge, B Cheng, Q Su |
Annals of translational medicine | 2021 |
|
Danger-associated molecular pattern molecules and the receptor for advanced glycation end products enhance ANCA-induced responses
T Page, D Chiappo, F Brunini, J Garnica, J Blackburn, F Dudhiya, M Prendecki, S McAdoo, C Pusey |
Rheumatology | 2021 |
|
The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function
W Skronska-Wasek, S Durlanik, H Le, V Schroeder, K Kitt, J Garnett, S Pflanz |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2021 |
|
Surgical trauma‐induced immunosuppression in cancer: Recent advances and the potential therapies
F Tang, Y Tie, C Tu, X Wei |
Clinical and Translational Medicine | 2020 |
|
PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism
S Liu, Y Xie, W Luo, Y Dou, H Xiong, Z Xiao, XL Zhang |
Frontiers in microbiology | 2020 |
|
S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation
D Viemann |
Frontiers in immunology | 2020 |
|
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
A Silvin, N Chapuis, G Dunsmore, AG Goubet, A Dubuisson, L Derosa, C Almire, C Hénon, O Kosmider, N Droin, P Rameau, C Catelain, A Alfaro, C Dussiau, C Friedrich, E Sourdeau, N Marin, TA Szwebel, D Cantin, L Mouthon, D Borderie, M Deloger, D Bredel, S Mouraud, D Drubay, M Andrieu, AS Lhonneur, V Saada, A Stoclin, C Willekens, F Pommeret, F Griscelli, LG Ng, Z Zhang, P Bost, I Amit, F Barlesi, A Marabelle, F Pène, B Gachot, F André, L Zitvogel, F Ginhoux, M Fontenay, E Solary |
Cell | 2020 |
|
S100A8/A9 in Myocardial Infarction: A Promising Biomarker and Therapeutic Target
ZL Cai, Q Xie, T Hu, Q Yao, J Zhao, Q Wu, Q Tang |
Frontiers in Cell and Developmental Biology | 2020 |
|
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
A Marki, K Buscher, C Lorenzini, M Meyer, R Saigusa, Z Fan, YT Yeh, N Hartmann, JM Dan, WB Kiosses, GJ Golden, R Ganesan, H Winkels, M Orecchioni, S McArdle, Z Mikulski, Y Altman, J Bui, M Kronenberg, S Chien, JD Esko, V Nizet, D Smalley, J Roth, K Ley |
Journal of Experimental Medicine | 2020 |
|
The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis
AB Blom, MH van den Bosch, EN Davidson, J Roth, T Vogl, FA van de Loo, M Koenders, PM van der Kraan, EJ Geven, PL van Lent |
Arthritis Research & Therapy | 2020 |
|
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis
KM Sohn, SG Lee, HJ Kim, S Cheon, H Jeong, J Lee, IS Kim, P Silwal, YJ Kim, S Paik, C Chung, C Park, YS Kim, EK Jo |
Journal of Korean Medical Science | 2020 |
|
Roles of Interactions Between Toll-Like Receptors and Their Endogenous Ligands in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still’s Disease
JY Jung, JW Kim, CH Suh, HA Kim |
Frontiers in immunology | 2020 |
|
Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis
JY Ma, S Shao, G Wang |
Chinese Medical Journal | 2020 |
|
S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis
N Tomonobu, R Kinoshita, M Sakaguchi |
Translational oncology | 2020 |
|
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation
X Duan, X Liu, N Liu, Y Huang, Z Jin, S Zhang, Z Ming, H Chen |
Cell Death and Disease | 2020 |
|
Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis
I Müller, T Vogl, U Kühl, A Krannich, A Banks, T Trippel, M Noutsias, AS Maisel, S Linthout, C Tschöpe |
ESC Heart Failure | 2020 |
|
Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions
DM Mossel, K Moganti, V Riabov, C Weiss, S Kopf, J Cordero, G Dobreva, MG Rots, H Klüter, MC Harmsen, J Kzhyshkowska |
Frontiers in immunology | 2020 |
|
Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9
JL Harman, AN Loes, GD Warren, MC Heaphy, KJ Lampi, MJ Harms |
eLife | 2020 |
|
Elevated S100A9 expression in chronic rhinosinusitis coincides with elevated MMP production and proliferation in vitro
M Boruk, C Railwah, A Lora, S Nath, D Wu, L Chow, P Borhanjoo, AJ Dabo, S Chowdhury, R Kaiser, RF Foronjy, R Rosenfeld, P Geraghty |
Scientific Reports | 2020 |
|
Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma
DH Kim, A Gu, JS Lee, EJ Yang, A Kashif, MH Hong, G Kim, BS Park, SJ Lee, IS Kim |
International journal of medical sciences | 2020 |
|
S100A9 extends lifespan in insulin deficiency
G Ramadori, S Ljubicic, S Ricci, D Mikropoulou, X Brenachot, C Veyrat-Durebex, E Aras, RM Ioris, J Altirriba, E Malle, D Foell, T Vogl, R Coppari |
Nature Communications | 2019 |
|
Ubiquitination of Listeria Virulence Factor InlC Contributes to the Host Response to Infection
E Gouin, D Balestrino, O Rasid, MA Nahori, V Villiers, F Impens, S Volant, T Vogl, Y Jacob, O Dussurget, P Cossart, NE Freitag |
mBio | 2019 |
|
Synergistic TLR/IFNα/β-Signaling Facilitates Escape of IL-18 Expression from Endotoxin Tolerance
E Verweyen, D Holzinger, T Weinhage, C Hinze, H Wittkowski, P Pickkers, S Albeituni, K Verbist, KE Nichols, G Schulert, A Grom, D Foell, C Kessel |
American journal of respiratory and critical care medicine | 2019 |
|
Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases
D Holzinger, K Tenbrock, J Roth |
Frontiers in immunology | 2019 |
|
S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma
M Huang, R Wu, L Chen, Q Peng, S Li, Y Zhang, L Zhou, L Duan |
Frontiers in immunology | 2019 |
|
The role of calprotectin in rheumatoid arthritis
Q Wang, W Chen, J Lin |
Journal of Translational Internal Medicine | 2019 |
|
miRNAs Regulate Cytokine Secretion Induced by Phosphorylated S100A8/A9 in Neutrophils
N Jung, V Schenten, JL Bueb, F Tolle, S Bréchard |
International journal of molecular sciences | 2019 |
|
Circulating calprotectin (S100A8/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs
EC de Moel, J Rech, M Mahler, J Roth, T Vogl, A Schouffoer, RJ Goekoop, TW Huizinga, CF Allaart, RE Toes, G Schett, D van der Woude |
Arthritis Research & Therapy | 2019 |
|
Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?: The importance of alarmins in OA
MH van den Bosch |
Clinical & Experimental Immunology | 2018 |
|
The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status
M Kasper, K Walscheid, B Laffer, D Bauer, M Busch, L Wildschütz, B Wang, K Loser, T Vogl, RS Grajewski, T Langmann, A Heiligenhaus |
Frontiers in immunology | 2018 |
|
S100 proteins as therapeutic targets
AR Bresnick |
Biophysical Reviews | 2018 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)