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Citations to this article

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
Robert Pyo, … , Robert M. Senior, Robert W. Thompson
Robert Pyo, … , Robert M. Senior, Robert W. Thompson
Published June 1, 2000
Citation Information: J Clin Invest. 2000;105(11):1641-1649. https://doi.org/10.1172/JCI8931.
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Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

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Abstract

Abdominal aortic aneurysms represent a life-threatening condition characterized by chronic inflammation, destructive remodeling of the extracellular matrix, and increased local expression of matrix metalloproteinases (MMPs). Both 92-kD gelatinase (MMP-9) and macrophage elastase (MMP-12) have been implicated in this disease, but it is not known if either is necessary in aneurysmal degeneration. We show here that transient elastase perfusion of the mouse aorta results in delayed aneurysm development that is temporally associated with transmural mononuclear inflammation, increased local production of several elastolytic MMPs, and progressive destruction of the elastic lamellae. Elastase-induced aneurysmal degeneration was suppressed by treatment with a nonselective MMP inhibitor (doxycycline) and by targeted gene disruption of MMP-9, but not by isolated deficiency of MMP-12. Bone marrow transplantation from wild-type mice prevented the aneurysm-resistant phenotype in MMP-9–deficient animals, and wild-type mice acquired aneurysm resistance after transplantation from MMP-9–deficient donors. These results demonstrate that inflammatory cell expression of MMP-9 plays a critical role in an experimental model of aortic aneurysm disease, suggesting that therapeutic strategies targeting MMP-9 may limit the growth of small abdominal aortic aneurysms.

Authors

Robert Pyo, Jason K. Lee, J. Michael Shipley, John A. Curci, Dongli Mao, Scott J. Ziporin, Terri L. Ennis, Steven D. Shapiro, Robert M. Senior, Robert W. Thompson

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 Total
Citations: 6 7 17 21 21 14 18 14 14 9 17 14 13 21 15 17 19 11 8 6 3 7 3 4 4 4 307
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Citations to this article in year 2011 (15)

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J Xiao, J Angsana, J Wen, SV Smith, PW Park, ML Ford, CA Haller, EL Chaikof
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Matrix Metalloproteinase Activation Predicts Amelioration of Remodeling After Dietary Modification in Injured Arteries
S Tavakoli, M Razavian, J Zhang, L Nie, R Marfatia, LW Dobrucki, AJ Sinusas, S Robinson, DS Edwards, MM Sadeghi
Arteriosclerosis, thrombosis, and vascular biology 2011
Animal Models of Cardiovascular Diseases
C Zaragoza, C Gomez-Guerrero, JL Martin-Ventura, L Blanco-Colio, B Lavin, B Mallavia, C Tarin, S Mas, A Ortiz, J Egido
Journal of Biomedicine and Biotechnology 2011
Assessment of Elastase-Induced Murine Abdominal Aortic Aneurysms: Comparison of Ultrasound Imaging with In Situ Video Microscopy
J Azuma, L Maegdefessel, T Kitagawa, RL Dalman, MV McConnell, PS Tsao
Journal of Biomedicine and Biotechnology 2011
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases
Y Qin, GP Shi
Pharmacology & Therapeutics 2011
Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach
A Didangelos, X Yin, K Mandal, A Saje, A Smith, Q Xu, M Jahangiri, M Mayr
Molecular & cellular proteomics : MCP 2011
Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice
J Sun, GK Sukhova, J Zhang, H Chen, S Sjöberg, P Libby, M Xiang, J Wang, C Peters, T Reinheckel, GP Shi
Arteriosclerosis, thrombosis, and vascular biology 2011
Differential Roles of Endothelin-1 in Angiotensin II-Induced Atherosclerosis and Aortic Aneurysms in Apolipoprotein E-Null Mice
RS Suen, SN Rampersad, DJ Stewart, DW Courtman
The American Journal of Pathology 2011
Elastogenic Inductability of Smooth Muscle Cells from a Rat Model of Late Stage Abdominal Aortic Aneurysms
CE Gacchina, P Deb, JL Barth, A Ramamurthi
Tissue Engineering Part A 2011
Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties
KL Monson, MM Matsumoto, WL Young, GT Manley, T Hashimoto
Journal of the Mechanical Behavior of Biomedical Materials 2011
Bone marrow–derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation
CW Moehle, CM Bhamidipati, MR Alexander, GS Mehta, JN Irvine, M Salmon, GR Upchurch, IL Kron, GK Owens, G Ailawadi
The Journal of Thoracic and Cardiovascular Surgery 2011
Three-dimensional microstructural changes in murine abdominal aortic aneurysms quantified using immunofluorescent array tomography
S Saatchi, J Azuma, N Wanchoo, SJ Smith, PG Yock, CA Taylor, PS Tsao
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2011
Mast Cell Tryptase Deficiency Attenuates Mouse Abdominal Aortic Aneurysm Formation
J Zhang, J Sun, JS Lindholt, GK Sukhova, M Sinnamon, RL Stevens, R Adachi, P Libby, RW Thompson, GP Shi
Circulation research 2011
Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms
CJ Goergen, J Azuma, KN Barr, L Magdefessel, DY Kallop, A Gogineni, A Grewall, RM Weimer, AJ Connolly, RL Dalman, CA Taylor, PS Tsao, JM Greve
Arteriosclerosis, thrombosis, and vascular biology 2011
Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.
Gorski JP
2011

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