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Citations to this article

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
Robert Pyo, … , Robert M. Senior, Robert W. Thompson
Robert Pyo, … , Robert M. Senior, Robert W. Thompson
Published June 1, 2000
Citation Information: J Clin Invest. 2000;105(11):1641-1649. https://doi.org/10.1172/JCI8931.
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Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

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Abstract

Abdominal aortic aneurysms represent a life-threatening condition characterized by chronic inflammation, destructive remodeling of the extracellular matrix, and increased local expression of matrix metalloproteinases (MMPs). Both 92-kD gelatinase (MMP-9) and macrophage elastase (MMP-12) have been implicated in this disease, but it is not known if either is necessary in aneurysmal degeneration. We show here that transient elastase perfusion of the mouse aorta results in delayed aneurysm development that is temporally associated with transmural mononuclear inflammation, increased local production of several elastolytic MMPs, and progressive destruction of the elastic lamellae. Elastase-induced aneurysmal degeneration was suppressed by treatment with a nonselective MMP inhibitor (doxycycline) and by targeted gene disruption of MMP-9, but not by isolated deficiency of MMP-12. Bone marrow transplantation from wild-type mice prevented the aneurysm-resistant phenotype in MMP-9–deficient animals, and wild-type mice acquired aneurysm resistance after transplantation from MMP-9–deficient donors. These results demonstrate that inflammatory cell expression of MMP-9 plays a critical role in an experimental model of aortic aneurysm disease, suggesting that therapeutic strategies targeting MMP-9 may limit the growth of small abdominal aortic aneurysms.

Authors

Robert Pyo, Jason K. Lee, J. Michael Shipley, John A. Curci, Dongli Mao, Scott J. Ziporin, Terri L. Ennis, Steven D. Shapiro, Robert M. Senior, Robert W. Thompson

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 Total
Citations: 6 7 17 21 21 14 18 14 14 9 17 14 13 21 15 17 19 11 8 6 3 7 3 4 4 4 307
Citation information
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Citations to this article in year 2008 (11)

Title and authors Publication Year
Plasminogen-dependent Macrophage Trans-Extracellular Matrix Migration Requires Matrix Metalloproteinase-9 Activation in vivo
Yanqing Gong, Erika Hart, Aleksey Shchurin, Jane Hoover-Plow
Journal of Clinical Investigation 2008
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice
X Ma, M Tittiger, RH Knutsen, A Kovacs, L Schaller, RP Mecham, KP Ponder
Molecular Genetics and Metabolism 2008
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis
JA Jones, FG Spinale, JS Ikonomidis
Journal of Vascular Research 2008
Gene expression analysis of a porcine native abdominal aortic aneurysm model
M Sadek, RL Hynecek, S Goldenberg, KC Kent, ML Marin, PL Faries
Surgery 2008
Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm
L Smallwood, R Allcock, F Bockxmeer, N Warrington, LJ Palmer, B Iacopetta, J Golledge, PE Norman
The British journal of surgery 2008
A randomized, placebo-controlled trial of doxycycline after endoluminal aneurysm repair
AE Hackmann, BG Rubin, LA Sanchez, PA Geraghty, RW Thompson, JA Curci
Journal of Vascular Surgery 2008
Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
W Xiong, RA Knispel, HC Dietz, F Ramirez, BT Baxter
Journal of Vascular Surgery 2008
Differential Regulation of Aortic Growth in Male and Female Rodents Is Associated With AAA Development
BS Cho, DT Woodrum, KJ Roelofs, JC Stanley, PK Henke, GR Upchurch
The Journal of surgical research 2008
SM22α-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
N El-Bizri, C Guignabert, L Wang, A Cheng, K Stankunas, CP Chang, Y Mishina, M Rabinovitch
Development (Cambridge, England) 2008
Cardiovascular Activity
Vogel HG
2008
The development of abdominal aortic aneurysms in mice is enhanced by benzo(a)pyrene
Zhang Y, Ramos KS
Vascular Health and Risk Management 2008

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