We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure–associated locus within the
Xue Bai, Kevin D. Mangum, Rachel A. Dee, George A. Stouffer, Craig R. Lee, Akinyemi Oni-Orisan, Cam Patterson, Jonathan C. Schisler, Anthony J. Viera, Joan M. Taylor, Christopher P. Mack
Title and authors | Publication | Year |
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Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling
Kevin D Mangum, Qinmengge Li, Katherine Hartmann, Tyler M Bauer, Sonya J. Wolf, James Shadiow, Jadie Y. Moon, Emily Barrett, Amrita Joshi, Gabriela Saldana de Jimenez, Sabrina A. Rocco, Zara Ahmed, Rachael Bogle, Kylie Boyer, Andrea Obi, Frank M Davis, Lin Chang, Lam Tsoi, Johann Gudjonsson, Scott M. Damrauer, Katherine Gallagher |
Journal of Clinical Investigation | 2025 |
Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration
Yao H, Chen J, Wang Y, Li Y, Tang P, Liang M, Jiang Q |
BMC Pregnancy and Childbirth | 2025 |
Serum response factor promoting axonal regeneration by activating the Ras–Raf‐Cofilin signaling pathway after the spinal cord injury
Gao L, Zhang C, Zhu Y, Zhang N, Zhang C, Zhou S, Feng G, Huang F, Zhang L |
CNS Neuroscience & Therapeutics | 2024 |
Gene editing of angiotensin for blood pressure management
Masi S, Dalpiaz H, Borghi C |
International Journal of Cardiology. Cardiovascular Risk and Prevention | 2024 |
Prdm6 promotes a ductus arteriosus-selective gene program in smooth muscle cells that drives ductus arteriosus contractility and closure
Meng Zou, Kevin D Mangum, Justin C Magin, Heidi H Cao, Michael T Yarboro, Elaine L. Shelton, Joan Taylor, Jeff Reese, Terrence Furey, Christopher Mack |
JCI Insight | 2023 |
Semaphorin3A Exacerbates Cardiac Microvascular Rarefaction in Pressure Overload‐Induced Heart Disease
Li C, Zhao Y, Li F, Wang Z, Qiu Z, Yang Y, Xiong W, Wang R, Chen H, Xu F, Zang T, Pei Z, Wang Y, Shi B, Shen L, Ge J |
Advanced Science | 2023 |
Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.
Ye Z, Mo C, Liu S, Gao S, Feng L, Zhao B, Canida T, Wu YC, Hatch KS, Ma Y, Mitchell BD, Hong LE, Kochunov P, Chen C, Zhao B, Chen S, Ma T |
Journal of Neuroscience Research | 2023 |
Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci
Hodonsky CJ, Turner AW, Khan MD, Barrientos NB, Methorst R, Ma L, Lopez NG, Mosquera JV, Auguste G, Farber E, Ma WF, Wong D, Onengut-Gumuscu S, Kavousi M, Peyser PA, van der Laan SW, Leeper NJ, Kovacic JC, Björkegren JL, Miller CL |
2023 | |
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
A Alsheikh, S Wollenhaupt, E King, J Reeb, S Ghosh, L Stolzenburg, S Tamim, J Lazar, J Davis, H Jacob |
BMC Medical Genomics | 2022 |
Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity
M Arvanitis, K Tayeb, B Strober, A Battle |
The American Journal of Human Genetics | 2022 |
Unfolding the genotype-to-phenotype black box of cardiovascular diseases through cross-scale modeling.
Xi X, Li H, Chen S, Lv T, Ma T, Jiang R, Zhang P, Wong WH, Zhang X |
iScience | 2022 |
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS |
Circulation research | 2022 |
Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases
CC Tseng, MC Wong, WT Liao, CJ Chen, SC Lee, JH Yen, SJ Chang |
International journal of molecular sciences | 2021 |
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings
Q Li, M Dibus, A Casey, CS Yee, SO Vargas, S Luo, SM Rosen, JA Madden, CA Genetti, J Brabek, CA Brownstein, S Kazerounian, BA Raby, K Schmitz-Abe, JC Kennedy, MP Fishman, MP Mullen, JM Taylor, D Rosel, PB Agrawal, RQ Cron |
PLoS genetics | 2021 |
The actin depolymerizing factor destrin serves as a negative feedback inhibitor of smooth muscle cell differentiation
KA Liao, KV Rangarajan, X Bai, JM Taylor, CP Mack |
American journal of physiology. Heart and circulatory physiology | 2021 |
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension
C Li, L Ma, Q Wang, X Shao, L Guo, J Chen, W Wang, J Yu |
Journal of Hypertension | 2021 |
Crispr-Cas9 deletion of hepatic Angiotensinogen gene results in sustained control of Hypertension: A Potential for Cure?
Sun H, Hodgkinson CP, Pratt RE, Dzau VJ |
2021 | |
Transcriptional and posttranscriptional regulation of the SMC-selective blood pressure-associated gene, ARHGAP42
KD Mangum, EJ Freeman, JC Magin, JM Taylor, CP Mack |
American journal of physiology. Heart and circulatory physiology | 2020 |
Transforming growth factor β‐mediated micromechanics modulates disease progression in primary myelofibrosis
P Teodorescu, S Pasca, A Jurj, G Gafencu, JP Joelsson, S Selicean, C Moldovan, R Munteanu, A Onaciu, AB Tigu, M Buse, AA Zimta, R Stiufiuc, B Petrushev, M Desmirean, D Dima, C Vlad, JT Bergthorsson, C Berce, S Ciurea, G Ghiaur, C Tomuleasa |
Journal of Cellular and Molecular Medicine | 2020 |
Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo
R Dee, X Bai, C Mack, J Taylor |
Cells | 2020 |
Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure–Associated Single Nucleotide Polymorphisms
M Mishra, E Liang, A Geurts, P Auer, P Liu, S Rao, A Greene, M Liang, Y Liu |
Hypertension | 2020 |
Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated
CP Cabrera, FL Ng, HL Nicholls, A Gupta, MR Barnes, PB Munroe, MJ Caulfield |
Human Molecular Genetics | 2019 |
Haploinsufficiency of ARHGAP42 is associated with hypertension
AS Fjorder, MB Rasmussen, MM Mehrjouy, L Nazaryan-Petersen, C Hansen, M Bak, N Grarup, A Nørremølle, LA Larsen, H Vestergaard, T Hansen, N Tommerup, I Bache |
European Journal of Human Genetics | 2019 |
A polymorphism in intron I of the human angiotensinogen gene ( hAGT ) affects binding by HNF3 and hAGT expression and increases blood pressure in mice
B Mopidevi, MK Kaw, I Sivankutty, S Jain, SK Perla, A Kumar |
The Journal of biological chemistry | 2019 |
Druggable targets in the Rho pathway and their promise for therapeutic control of blood pressure
RA Dee, KD Mangum, X Bai, CP Mack, JM Taylor |
Pharmacology & Therapeutics | 2019 |
Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension
AB Azam, EA Azizan |
International Journal of Endocrinology | 2018 |
GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure
X Bai, K Mangum, M Kakoki, O Smithies, CP Mack, JM Taylor |
Small GTPases | 2017 |
Role of ARHGAP42 in hypertension
EF Carney |
Nature Reviews Nephrology | 2017 |