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Clair Crewe, … , Yu Aaron An, Philipp E. Scherer
Published January 3, 2017
Citation Information: J Clin Invest. 2017;127(1):74-82. https://doi.org/10.1172/JCI88883.
Citation Information: J Clin Invest. 2017;127(1):74-82. https://doi.org/10.1172/JCI88883.
Abstract
There are three dominant contributors to the pathogenesis of dysfunctional adipose tissue (AT) in obesity: unresolved inflammation, inappropriate extracellular matrix (ECM) remodeling and insufficient angiogenic potential. The interactions of these processes during AT expansion reflect both a linear progression as well as feed-forward mechanisms. For example, both inflammation and inadequate angiogenic remodeling can drive fibrosis, which can in turn promote migration of immune cells into adipose depots and impede further angiogenesis. Therefore, the relationship between the members of this triad is complex but important for our understanding of the pathogenesis of obesity. Here we untangle some of these intricacies to highlight the contributions of inflammation, angiogenesis, and the ECM to both “healthy” and “unhealthy” AT expansion.
Authors
Clair Crewe, Yu Aaron An, Philipp E. Scherer
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Citations to this article (387)
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Editorial: Metabolic associated fatty liver disease: clinical perspectives from pathogenesis to diagnosis and treatment
Huang Z, Ye D, Loomes K, Cheng KK, Hui HX |
Frontiers in Endocrinology | 2023 |
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The beneficial effects of genetic or pharmacological GHSR blockade in rodents fed with a high-fat diet are sexually dimorphic
Andras Leko, Adriana Gregory-Flores, Renata Marchette, Juan Gomez, Janaina Vendruscolo, Vez Repunte-Canonigo, Vicky Chuong, Sara L. Deschaine, Kimberly Whiting, Shelley Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Kim Janda, Barry Zorman, Pavel Sumazin, George Koob, Michael Michaelides, Pietro Sanna, Leandro Vendruscolo, Lorenzo Leggio |
Research square | 2023 |
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The role of extracellular vesicle-derived miRNAs in adipose tissue function and metabolic health
Paneru BD, Hill DA |
2023 | |
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Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding
Hoch J, Burkhard N, Zhang S, Rieder M, Marchini T, Geest V, Krauel K, Zahn T, Schommer N, Hamad MA, Bauer C, Gauchel N, Stallmann D, Normann C, Wolf D, Scharf RE, Duerschmied D, Schanze N |
Frontiers in immunology | 2023 |
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Non-contrast CT-based radiomics nomogram of pericoronary adipose tissue for predicting haemodynamically significant coronary stenosis in patients with type 2 diabetes.
Chen C, Chen M, Tao Q, Hu S, Hu C |
BMC medical imaging | 2023 |
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White adipose tissue mitochondrial bioenergetics in metabolic diseases.
Sabaratnam R, Hansen DR, Svenningsen P |
Reviews in endocrine & metabolic disorders | 2023 |
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Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles.
Crewe C |
Comprehensive Physiology | 2023 |
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Effects of body mass index on the immune response within the first days after major stroke in humans.
Ruhnau J, Heuer C, Witt C, Ceesay S, Schulze J, Gross S, Waize M, Kromrey ML, Kühn JP, Langner S, Grunwald U, Bröker BM, Petersmann A, Steveling A, Dressel A, Vogelgesang A |
2023 | |
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Obesity phenotypes and cardiovascular risk: From pathophysiology to clinical management.
Preda A, Carbone F, Tirandi A, Montecucco F, Liberale L |
Reviews in endocrine & metabolic disorders | 2023 |
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Role of Leptin and Adiponectin in Carcinogenesis
Bocian-Jastrzębska A, Malczewska-Herman A, Kos-Kudła B |
Cancers | 2023 |
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Enhanced Angiogenesis in HUVECs Preconditioned with Media from Adipocytes Differentiated from Lipedema Adipose Stem Cells In Vitro
Al-Ghadban S, Walczak SG, Isern SU, Martin EC, Herbst KL, Bunnell BA |
International journal of molecular sciences | 2023 |
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Bilobalide Induces Apoptosis in 3T3-L1 Mature Adipocytes through ROS-Mediated Mitochondria Pathway
Bu S, Xiong A, Yang Z, Aissa-Brahim F, Chen Y, Zhang Y, Zhou X, Cao F |
Molecules (Basel, Switzerland) | 2023 |
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Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich’s ataxia mouse model
Turchi R, Sciarretta F, Ceci V, Tiberi M, Audano M, Pedretti S, Panebianco C, Nesci V, Pazienza V, Ferri A, Carotti S, Chiurchiù V, Mitro N, Lettieri-Barbato D, Aquilano K |
iScience | 2023 |
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Computed tomography measured epicardial adipose tissue and psoas muscle attenuation: new biomarkers to predict major adverse cardiac events (MACE) and mortality in patients with heart disease and critically ill patients. Part I: Epicardial adipose tissue
Walpot J, Van Herck P, Van de Heyning CM, Bosmans J, Massalha S, Malbrain ML, Heidbuchel H, Inácio JR |
2023 | |
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Human iPSC-derived proinflammatory macrophages cause insulin resistance in an isogenic white adipose tissue microphysiological system
Qi L, Matsuo K, Pereira A, Lee YT, Zhong F, He Y, Zushin PJ, Gröger M, Sharma A, Willenbring H, Hsiao EC, Stahl A |
Small (Weinheim an Der Bergstrasse, Germany) | 2023 |
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Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort.
Yew YW, Mina T, Ng HK, Lam BCC, Riboli E, Lee ES, Lee J, Ngeow J, Elliott P, Thng STG, Chambers JC, Loh M |
International Journal of Obesity | 2023 |
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Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans
Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K |
Frontiers in Cardiovascular Medicine | 2023 |
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Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue
Han X, Li W, He X, Lu X, Zhang Y, Li Y, Bi G, Ma X, Huang X, Bai R, Zhang H |
Stem Cell Research & Therapy | 2023 |
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The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity.
AlZaim I, de Rooij LPMH, Sheikh BN, Börgeson E, Kalucka J |
Nature reviews. Endocrinology | 2023 |
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Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity
Bairqdar A, Shakhtshneider E, Ivanoshchuk D, Mikhailova S, Kashtanova E, Shramko V, Polonskaya Y, Ragino Y |
Journal of Personalized Medicine | 2023 |
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Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.
Taylor J, Uhl L, Moll I, Hasan SS, Wiedmann L, Morgenstern J, Giaimo BD, Friedrich T, Alsina-Sanchis E, De Angelis Rigotti F, Mülfarth R, Kaltenbach S, Schenk D, Nickel F, Fleming T, Sprinzak D, Mogler C, Korff T, Billeter AT, Müller-Stich BP, Berriel Diaz M, Borggrefe T, Herzig S, Rohm M, Rodriguez-Vita J, Fischer A |
Nature cancer | 2023 |
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Generation of Connective Tissue-Free Microvascular Fragment Isolates from Subcutaneous Fat Tissue of Obese Mice.
Meßner FC, Metzger W, Marschall JE, Bickelmann C, Menger MD, Laschke MW |
Tissue Engineering and Regenerative Medicine | 2023 |
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Thrombospondin1 antagonist peptide treatment attenuates obesity-associated chronic inflammation and metabolic disorders in a diet-induced obese mouse model
Zhou Q, Gwag T, Wang S |
Scientific Reports | 2023 |
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Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis
Gong S, Li C, Leng Q, Liu C, Zhu Y, Zhang H, Li X |
Heliyon | 2023 |
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MiR-221-3p/222-3p Cluster Expression in Human Adipose Tissue Is Related to Obesity and Type 2 Diabetes.
Gentile AM, Lhamyani S, Mengual-Mesa M, García-Fuentes E, Bermúdez-Silva FJ, Rojo-Martínez G, Clemente-Postigo M, Rodriguez-Cañete A, Olveira G, El Bekay R |
International journal of molecular sciences | 2023 |
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Targeting the Adipose Tissue–Liver–Gut Microbiota Crosstalk to Cure MASLD
Gabbia D, De Martin S |
Biology | 2023 |
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CT Coronary Angiography: Technical Approach and Atherosclerotic Plaque Characterization.
Dell'Aversana S, Ascione R, Vitale RA, Cavaliere F, Porcaro P, Basile L, Napolitano G, Boccalatte M, Sibilio G, Esposito G, Franzone A, Di Costanzo G, Muscogiuri G, Sironi S, Cuocolo R, Cavaglià E, Ponsiglione A, Imbriaco M |
Journal of Clinical Medicine | 2023 |
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Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism.
Wang B, Du M |
Critical Reviews in Food Science and Nutrition | 2023 |
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The Importance of Nutrition in Menopause and Perimenopause—A Review
Erdélyi A, Pálfi E, Tűű L, Nas K, Szűcs Z, Török M, Jakab A, Várbíró S |
Nutrients | 2023 |
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Adipose tissue fibrosis: the unwanted houseguest invited by obesity
Gliniak CM, Pedersen L, Scherer PE |
The Journal of endocrinology | 2023 |
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Transcript profile of CLSTN3B gene in human white adipose tissue is associated with obesity and mitochondrial gene program
Bai N, Lu X, Wang Y, Li X, Zhang R, Yu H, Hu C, Ma X, Bao Y, Yang Y |
Life Metabolism | 2023 |
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Cyclooxygenase-2 in adipose tissue macrophages limits adipose tissue dysfunction in obese mice
Yu Pan, Shirong Cao, Jiaqi Tang, Juan P Arroyo, Andrew S Terker, Yinqiu Wang, Aolei Niu, Xiaofeng Fan, Suwan Wang, Yahua Zhang, Ming Jiang, David H. Wasserman, Ming-Zhi Zhang, Raymond Harris |
Journal of Clinical Investigation | 2022 |
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Targeting the vasculature in cardiometabolic disease
Nabil Boutagy, Abhishek Singh, William Sessa |
Journal of Clinical Investigation | 2022 |
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CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue
Ningning Bai, Xuhong Lu, Li Jin, Miriayi Alimujiang, Jingyuan Ma, Fan Hu, Yuejie Xu, Jingjing Sun, Jun Xu, Rong Zhang, Junfeng Han, Cheng Hu, Ying Yang |
Molecular Metabolism | 2022 |
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Obesity I: Overview and molecular and biochemical mechanisms
R Lustig, D Collier, C Kassotis, T Roepke, M Kim, E Blanc, R Barouki, A Bansal, M Cave, S Chatterjee, M Choudhury, M Gilbertson, D Lagadic-Gossmann, S Howard, L Lind, C Tomlinson, J Vondracek, J Heindel |
Biochemical Pharmacology | 2022 |
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Visceral adiposity, inflammation, and hippocampal function in obesity
A Stranahan |
Neuropharmacology | 2022 |
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Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis
S Wang, Y Liang, C Dai |
Kidney Diseases | 2022 |
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Angiogenesis: Methods and Protocols
A Benest |
2022 | |
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Survivin is essential for thermogenic program and metabolic homeostasis in mice
M Alimujiang, J Sun, S Chen, N Bai, S Chen, F Hu, J Ma, Y Xu, J Xu, X Ma, Y Yang |
Molecular Metabolism | 2022 |
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Adipocyte Utx Deficiency Promotes High-Fat Diet-Induced Metabolic Dysfunction in Mice
F Li, S Wang, X Cui, J Jing, L Yu, B Xue, H Shi |
Cells | 2022 |
|
Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity
A Dhore-patil, T Thannoun, R Samson, T Jemtel |
Frontiers in physiology | 2022 |
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Leptin to adiponectin ratio in puberty is associated with bone mineral density in 18-year-old males
R Tamme, J Jürimäe, E Mäestu, L Remmel, P Purge, E Mengel, V Tillmann |
Bone Reports | 2022 |
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Healthy Subcutaneous and Omental Adipose Tissue Is Associated with High Expression of Extracellular Matrix Components
M Soták, MR Rajan, M Clark, C Biörserud, V Wallenius, CE Hagberg, E Börgeson |
International journal of molecular sciences | 2022 |
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Why does obesity cause diabetes?
S Klein, A Gastaldelli, H Yki-Järvinen, P Scherer |
Cell Metabolism | 2022 |
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Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review
S Camastra, E Ferrannini |
Reviews in Endocrine and Metabolic Disorders | 2022 |
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Biological Determinants of Metabolic Syndrome in Visceral and Subcutaneous Adipose Tissue from Severely Obese Women
Ó Osorio-Conles, A Vega-Beyhart, A Ibarzabal, J Balibrea, J Vidal, A de Hollanda |
International journal of molecular sciences | 2022 |
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Gender differences in cardiometabolic health and disease in a cross-sectional observational obesity study
C Strack, G Behrens, S Sag, M Mohr, J Zeller, C Lahmann, U Hubauer, T Loew, L Maier, M Fischer, A Baessler |
Biology of sex differences | 2022 |
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The shades of grey in adipose tissue reprogramming
Y Qi, X Hui |
Bioscience Reports | 2022 |
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Adequacy and Vitamin D in the Preoperative Period of Roux-en-Y Gastric Bypass, Bariatric Surgery, Can Protect Metabolic Health in Metabolically Healthy and Unhealthy Individuals
S da Cruz, S Cruz, S Pereira, C Saboya, J Veiga, A Ramalho |
Nutrients | 2022 |
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Localization of aquaglyceroporins in human and murine white adipose tissue
F Iena, J Kalucka, L Nielsen, E Søndergaard, S Nielsen, J Lebeck |
Histochemistry and Cell Biology | 2022 |
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Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
S Maqdasy, S Lecoutre, G Renzi, S Frendo-Cumbo, D Rizo-Roca, T Moritz, M Juvany, O Hodek, H Gao, M Couchet, M Witting, A Kerr, M Bergo, R Choudhury, M Aouadi, J Zierath, A Krook, N Mejhert, M Rydén |
Nature metabolism | 2022 |
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Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process
A Kozlov |
Infectious agents and cancer | 2022 |
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P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet
F Raggi, C Rossi, F Faita, M Distaso, C Kusmic, A Solini |
Journal of inflammation research | 2022 |
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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance
V Pellegrinelli, S Rodriguez-Cuenca, C Rouault, E Figueroa-Juarez, H Schilbert, S Virtue, J Moreno-Navarrete, G Bidault, M Vázquez-Borrego, A Dias, B Pucker, M Dale, M Campbell, S Carobbio, Y Lin, M Vacca, J Aron-Wisnewsky, S Mora, M Masiero, A Emmanouilidou, S Mukhopadhyay, G Dougan, M den Hoed, R Loos, J Fernández-Real, D Chiarugi, K Clément, A Vidal-Puig |
Nature metabolism | 2022 |
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Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
R Hachiya, M Tanaka, M Itoh, T Suganami |
Inflammation and Regeneration | 2022 |
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Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9
Y Levy, T Ciaraldi, S Mudaliar, S Phillips, R Henry |
Adipocyte | 2022 |
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β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway
Y Zhou, T Takano, X Li, Y Wang, R Wang, Z Zhu, M Tanokura, T Miyakawa, S Hachimura |
2022 | |
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Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity
Crouse WL, Das SK, Le T, Keele G, Holl K, Seshie O, Craddock AL, Sharma NK, Comeau ME, Langefeld CD, Hawkins GA, Mott R, Valdar W, Solberg Woods LC |
Physiological genomics | 2022 |
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Large Yellow Tea Extract Ameliorates Metabolic Syndrome by Suppressing Lipogenesis through SIRT6/SREBP1 Pathway and Modulating Microbiota in Leptin Receptor Knockout Rats
Wu G, Sun X, Cheng H, Xu S, Li D, Xie Z |
Foods | 2022 |
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Obesity: The Fat Tissue Disease Version of Cancer
Boubertakh B, Silvestri C, Di Marzo V |
Cells | 2022 |
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Fecal carriage of vanB antibiotic resistance gene affects adipose tissue function under vancomycin use
Vliex LM, Le GN, Fassarella M, Reijnders D, Goossens GH, Zoetendal EG, Penders J, Blaak EE |
Gut microbes | 2022 |
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Cardiac computed tomography radiomics: a narrative review of current status and future directions
Shang J, Guo Y, Ma Y, Hou Y |
Quantitative imaging in medicine and surgery | 2022 |
|
Maternal and Offspring Sugar Consumption Increases Perigonadal Adipose Tissue Hypertrophy and Negatively Affects the Testis Histological Organization in Adult Rats
Gabriela CS, Leticia NT, Margarita CR, Nicté XA, María de Lourdes AC, Elena Z, Estela CR, Jorge RA |
Frontiers in Cell and Developmental Biology | 2022 |
|
Artificial Intelligence in Coronary CT Angiography: Current Status and Future Prospects
Liao J, Huang L, Qu M, Chen B, Wang G |
Frontiers in Cardiovascular Medicine | 2022 |
|
Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice
Chen KY, De Angulo A, Guo X, More A, Ochsner SA, Lopez E, Saul D, Pang W, Sun Y, McKenna NJ, Tong Q |
2022 | |
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Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan U, Varughese I, Sun AR, Wu X, Crawford R, Prasadam I |
Frontiers in immunology | 2022 |
|
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention
Zhu Y, Li N, Huang M, Chen X, An YA, Li J, Zhao S, Funcke JB, Cao J, He Z, Zhu Q, Zhang Z, Wang ZV, Xu L, Williams KW, Li C, Grove K, Scherer PE |
Acta pharmaceutica Sinica. B | 2022 |
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EGFR-mediated activation of adipose tissue macrophages promotes obesity and insulin resistance
Cao S, Pan Y, Tang J, Terker AS, Arroyo Ornelas JP, Jin GN, Wang Y, Niu A, Fan X, Wang S, Harris RC, Zhang MZ |
Nature Communications | 2022 |
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Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology
Lecoutre S, Lambert M, Drygalski K, Dugail I, Maqdasy S, Hautefeuille M, Clément K |
Cells | 2022 |
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Angiogenesis in adipose tissue and obesity.
Corvera S, Solivan-Rivera J, Yang Loureiro Z |
Angiogenesis | 2022 |
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The adipocyte microenvironment and cancer.
Mukherjee A, Bilecz AJ, Lengyel E |
Cancer metastasis reviews | 2022 |
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Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity
Osorio-Conles Ó, Olbeyra R, Moizé V, Ibarzabal A, Giró O, Viaplana J, Jiménez A, Vidal J, de Hollanda A |
Nutrients | 2022 |
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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM |
Redox Biology | 2022 |
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Cardiovascular Disease Risk Reduction and Body Mass Index.
Samson R, Ennezat PV, Le Jemtel TH, Oparil S |
Current Hypertension Reports | 2022 |
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Ultrasound Imaging of the Superficial Fascia in the Upper Limb: Arm and Forearm
Pirri C, Pirri N, Guidolin D, Macchi V, De Caro R, Stecco C |
Diagnostics | 2022 |
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Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
Catalán V, Domench P, Gómez-Ambrosi J, Ramírez B, Becerril S, Mentxaka A, Rodríguez A, Valentí V, Moncada R, Baixauli J, Silva C, Escalada J, Frühbeck G |
International journal of molecular sciences | 2022 |
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Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases.
Pellegata NS, Berriel Diaz M, Rohm M, Herzig S |
Cancer metastasis reviews | 2022 |
|
Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis.
Liu X, Lu F, Chen X |
Frontiers in immunology | 2022 |
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Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice
Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S |
The Journal of biological chemistry | 2022 |
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Enoxacin ameliorates polycystic ovary syndrome by promoting the browning of white adipose tissue and restoring gut dysbiosis
Zhu W, Fu L, Xu C, Peng K, Liu Y, Tang H, Huang Y, Yang X |
Frontiers in pharmacology | 2022 |
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The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y |
Nature Communications | 2022 |
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Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis
Han DJ, Aslam R, Misra PS, Chiu F, Ojha T, Chowdhury A, Chan CK, Sung HK, Yuen DA, Luk CT |
Molecular Metabolism | 2022 |
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Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity.
Ruggiero AD, Vemuri R, Block M, DeStephanis D, Davis M, Chou J, Williams A, Brock A, Das SK, Kavanagh K |
International journal of molecular sciences | 2022 |
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Comprehensive analysis of epigenomics and transcriptome data to identify potential target genes associated with obesity.
Wu P, Guo L, Li X, Du Y, Lin X, Ma X, Lin Y, Wen C, Yang C, Liu N, Feng Q, Xue Y, Guan M |
Frontiers in Genetics | 2022 |
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Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise.
Razi O, Teixeira AM, Tartibian B, Zamani N, Knechtle B |
Molecular and Cellular Biochemistry | 2022 |
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Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity.
Bondareva O, Rodríguez-Aguilera JR, Oliveira F, Liao L, Rose A, Gupta A, Singh K, Geier F, Schuster J, Boeckel JN, Buescher JM, Kohli S, Klöting N, Isermann B, Blüher M, Sheikh BN |
Nature metabolism | 2022 |
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Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
Wang R, Sun Q, Wu X, Zhang Y, Xing X, Lin K, Feng Y, Wang M, Wang Y, Wang R |
Cells | 2022 |
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Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice
Dahan T, Nassar S, Yajuk O, Steinberg E, Benny O, Abudi N, Plaschkes I, Benyamini H, Gozal D, Abramovitch R, Gileles-Hillel A |
International journal of molecular sciences | 2022 |
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Obese visceral fat tissue inflammation: from protective to detrimental?
Kolb H |
BMC Medicine | 2022 |
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Anti-inflammatory response to curcumin supplementation in chronic kidney disease and hemodialysis patients: A systematic review and meta-analysis
Emami E, Heidari-Soureshjani S, Sherwin CM |
Avicenna journal of phytomedicine | 2022 |
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Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles.
Crewe C, Chen S, Bu D, Gliniak CM, Wernstedt Asterholm I, Yu XX, Joffin N, de Souza CO, Funcke JB, Oh DY, Varlamov O, Robino JJ, Gordillo R, Scherer PE |
Diabetes | 2022 |
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Obesity and Its Multiple Clinical Implications between Inflammatory States and Gut Microbiotic Alterations
Milano W, Carizzone F, Foia M, Marchese M, Milano M, Saetta B, Capasso A |
Diseases | 2022 |
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Adipose Tissue Remodeling in Pathophysiology
Auger C, Kajimura S |
Annual review of pathology | 2022 |
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Machine-learning-based radiomics identifies atrial fibrillation on the epicardial fat in contrast-enhanced and non-enhanced chest CT.
Zhang L, Xu Z, Jiang B, Zhang Y, Wang L, de Bock GH, Vliegenthart R, Xie X |
British Journal of Radiology | 2022 |
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Adipose tissue plasticity in health and disease
Sakers A, De Siqueira MK, Seale P, Villanueva CJ |
Cell | 2022 |
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GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
Ricardo J Samms, Michael E Christe, Kyla A Collins, Valentina Pirro, Brian A Droz, Adrienne K. Holland, Jessica L Friedrich, Samantha Wojnicki, Debra L Konkol, Richard Cosgrove, Ellen P. S. Conceição Furber, Xiaoping Ruan, Libbey O'Farrell, Annie M Long, Mridula Dogra, Jill Willency, Yanzhu Lin, Liyun Ding, Christine C Cheng, Over Cabrera, Daniel A Briere, Jorge Alsina-Fernandez, Ruth Gimeno, Julie S. Moyers, Tamer Coskun, Matthew P. Coghlan, Kyle Sloop, William C Roell |
Journal of Clinical Investigation | 2021 |
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Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E Dupont-Versteegden, Philip A. Kern |
JCI Insight | 2021 |
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Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation
Y Zhou, T Takano, Y Wang, X Li, R Wang, Y Wakatsuki, H Nakajima-Adachi, M Tanokura, T Miyakawa, S Hachimura |
iScience | 2021 |
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Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes
MS Isidor, W Dong, RI Servin-Uribe, J Villarroel, A Altıntaş, JT Ayala-Sumuano, A Varela-Echavarría, R Barrès, G Stephanopoulos, Y Macotela, B Emanuelli |
International Journal of Obesity | 2021 |
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Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution
PC Alarcon, MS Damen, R Madan, GS Deepe, P Spearman, SS Way, S Divanovic |
Mucosal Immunology | 2021 |
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Sphingolipids in metabolic disease: The good, the bad, and the unknown
CD Green, M Maceyka, LA Cowart, S Spiegel |
Cell Metabolism | 2021 |
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Adiponectin, Leptin and Cardiovascular Disorders
S Zhao, CM Kusminski, PE Scherer |
Circulation research | 2021 |
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In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes
D Lopez-Perez, A Redruello-Romero, J Garcia-Rubio, C Arana, LA Garcia-Escudero, F Tamayo, JD Puentes-Pardo, S Moreno-SanJuan, J Salmeron, A Blanco, J Galvez, J Leon, Á Carazo |
Frontiers in immunology | 2021 |
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The aetiology and molecular landscape of insulin resistance
DE James, J Stöckli, MJ Birnbaum |
Nature Reviews Molecular Cell Biology | 2021 |
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The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?
S Bini, L DErasmo, AD Costanzo, I Minicocci, V Pecce, M Arca |
International journal of molecular sciences | 2021 |
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Chronic circadian shift leads to adipose tissue inflammation and fibrosis
X Xiong, Y Lin, J Lee, A Paul, V Yechoor, M Figueiro, K Ma |
Molecular and Cellular Endocrinology | 2021 |
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Cellular and Molecular Players in the Interplay between Adipose Tissue and Breast Cancer
F Reggiani, P Falvo, F Bertolini |
International journal of molecular sciences | 2021 |
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Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
AD Ruggiero, CC Key, K Kavanagh |
Frontiers in Nutrition | 2021 |
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Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling
F Scarano, M Gliozzi, MC Zito, L Guarnieri, C Carresi, R Macrì, S Nucera, M Scicchitano, F Bosco, S Ruga, AR Coppoletta, R Mollace, J Maiuolo, I Bava, A Cardamone, M Ragusa, E Palma, V Musolino, V Mollace |
International journal of molecular sciences | 2021 |
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Aging adipose: Depot location dictates age-associated expansion and dysfunction
HV Bank, C Kirsh, J Simcox |
Ageing Research Reviews | 2021 |
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High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice Are Reduced by Inhibiting Sialidases
D Pilling, TR Karhadkar, RH Gomer |
The American Journal of Pathology | 2021 |
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Adipocyte-Derived Extracellular Vesicles: State of the Art
S Rome, A Blandin, SL Lay |
International journal of molecular sciences | 2021 |
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Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity
N Harasymowicz, N Rashidi, A Savadipour, C Wu, R Tang, J Bramley, W Buchser, F Guilak |
The FASEB Journal | 2021 |
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Factors Affecting Metabolic Outcomes Post Bariatric Surgery: Role of Adipose Tissue
SH Keshavjee, KJ Schwenger, J Yadav, TD Jackson, A Okrainec, JP Allard |
Journal of Clinical Medicine | 2021 |
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Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice
MP Franczyk, M He, J Yoshino |
Journal of the Endocrine Society | 2021 |
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Obesity, Type 2 Diabetes, and Cancer Risk
T Scully, A Ettela, D LeRoith, EJ Gallagher |
Frontiers in Oncology | 2021 |
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Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties
SL Lay, S Rome, X Loyer, L Nieto |
FASEB bioAdvances | 2021 |
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GHS-R suppression in adipose tissues protects against obesity and insulin resistance by regulating adipose angiogenesis and fibrosis
JH Lee, C Fang, X Li, CS Wu, JY Noh, X Ye, RS Chapkin, K Sun, Y Sun |
International Journal of Obesity | 2021 |
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Deletion of Seipin Attenuates Vascular Function and the Anticontractile Effect of Perivascular Adipose Tissue
M Wang, J Xing, M Liu, M Gao, Y Liu, X Li, L Hu, X Zhao, J Liao, G Liu, J Dong |
Frontiers in Cardiovascular Medicine | 2021 |
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Perivascular fat imaging by computed tomography (CT): a virtual guide
CP Kotanidis, C Antoniades |
British Journal of Pharmacology | 2021 |
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Proteomics study on the effect of silybin on cardiomyopathy in obese mice
F Wang, Z Li, T Song, Y Jia, L Qi, L Ren, S Chen |
Scientific Reports | 2021 |
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Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
PJ Verschoor, FH Greig, JJ Rochford, G Levate, M Delibegovic, D Thompson, A Leeson-Payne, R Dekeryte, R Banks, JW Ramos, GF Nixon |
Scientific Reports | 2021 |
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Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
T Hunyenyiwa, K Hendee, K Matus, P Kyi, T Mammoto, A Mammoto |
Frontiers in Cell and Developmental Biology | 2021 |
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Angiogenesis in Adipose Tissue: The Interplay Between Adipose and Endothelial Cells
J Herold, J Kalucka |
Frontiers in physiology | 2021 |
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MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance
D Becker-Greene, H Li, D Perez-Cremades, W Wu, F Bestepe, D Ozdemir, CE Niosi, C Aydogan, DP Orgill, MW Feinberg, B Icli |
Cellular and Molecular Life Sciences | 2021 |
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Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?
GM Martin-Nuñez, I Cornejo-Pareja, M Clemente-Postigo, FJ Tinahones |
Frontiers in Endocrinology | 2021 |
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Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets
A von Eckardstein, C Binder |
2021 | |
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Recent Developments in Extracellular Matrix Remodeling for Fat Grafting
X Bi, Y Li, Z Dong, J Zhao, W Wu, J Zou, L Guo, F Lu, J Gao |
Frontiers in Cell and Developmental Biology | 2021 |
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Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
F Li, J Jing, M Movahed, X Cui, Q Cao, R Wu, Z Chen, L Yu, Y Pan, H Shi, H Shi, B Xue |
Nature Communications | 2021 |
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Impact of Bariatric Surgery on Adipose Tissue Biology
Ó Osorio-Conles, J Vidal, A de Hollanda |
Journal of Clinical Medicine | 2021 |
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Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution
KJ Kolnes, MH Petersen, T Lien-Iversen, K Højlund, J Jensen |
Frontiers in physiology | 2021 |
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The Aging Vasculature: Glucose Tolerance, Hypoglycemia and the Role of the Serum Response Factor
H Aberdeen, K Battles, A Taylor, J Garner-Donald, A Davis-Wilson, BT Rogers, C Cavalier, ED Williams |
Journal of Cardiovascular Development and Disease | 2021 |
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Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
SH Hammoud, I AlZaim, Y Al-Dhaheri, AH Eid, AF El-Yazbi |
Frontiers in Endocrinology | 2021 |
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Obesity-induced cognitive impairment in older adults: a microvascular perspective
P Balasubramanian, T Kiss, S Tarantini, Á Nyúl-Tóth, C Ahire, A Yabluchanskiy, T Csipo, A Lipecz, A Tabak, A Institoris, A Csiszar, Z Ungvari |
American journal of physiology. Heart and circulatory physiology | 2021 |
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Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling
IG de Segura, P Ahechu, J Gómez-Ambrosi, A Rodríguez, B Ramírez, S Becerril, X Unamuno, A Mentxaka, J Baixauli, V Valentí, R Moncada, C Silva, G Frühbeck, V Catalán |
International journal of molecular sciences | 2021 |
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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
H Tanaka, K Kondo, K Fujita, H Homma, K Tagawa, X Jin, M Jin, Y Yoshioka, S Takayama, H Masuda, R Tokuyama, Y Nakazaki, T Saito, T Saido, S Murayama, T Ikura, N Ito, Y Yamamori, K Tomii, ME Bianchi, H Okazawa |
2021 | |
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Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion
H Sakashita, S Yamada, M Kinoshita, T Kajikawa, T Iwayama, S Murakami |
Scientific Reports | 2021 |
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In severe obesity, subcutaneous adipose tissue cell-derived cytokines are early markers of impaired glucose tolerance and are modulated by quercetin
V DEsposito, MR Ambrosio, D Liguoro, G Perruolo, M Lecce, S Cabaro, M Aprile, A Marino, V Pilone, P Forestieri, C Miele, D Bruzzese, D Terracciano, F Beguinot, P Formisano |
International Journal of Obesity | 2021 |
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Prediction of acute coronary syndrome within 3 years using radiomics signature of pericoronary adipose tissue based on coronary computed tomography angiography
J Shang, S Ma, Y Guo, L Yang, Q Zhang, F Xie, Y Ma, Q Ma, Y Dang, K Zhou, T Liu, J Yang, Y Hou |
European Radiology | 2021 |
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Degree of Creeping Fat Assessed by Computed Tomography Enterography is Associated with Intestinal Fibrotic Stricture in Patients with Crohn’s Disease: A Potentially Novel Mesenteric Creeping Fat Index
XH Li, ST Feng, QH Cao, JC Coffey, ME Baker, L Huang, ZN Fang, Y Qiu, BL Lu, ZH Chen, Y Li, D Bettenworth, M Iacucci, CH Sun, S Ghosh, F Rieder, MH Chen, ZP Li, R Mao |
Journal of Crohn's & colitis | 2021 |
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Editorial: The Role of the Lymphatic System in Lipid and Energy Metabolism, and Immune Homeostasis During Obesity and Diabetes
V Cifarelli, H Chen, JP Scallan |
Frontiers in physiology | 2021 |
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Coronary Computed Tomography Angiography Assessment of High-Risk Plaques in Predicting Acute Coronary Syndrome
G Lu, W Ye, J Ou, X Li, Z Tan, T Li, H Liu |
Frontiers in Cardiovascular Medicine | 2021 |
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Metabolically healthy obesity and physical fitness in military males in the CHIEF study
SH Wang, PS Chung, YP Lin, KZ Tsai, SC Lin, CH Fan, YK Lin, GM Lin |
Scientific Reports | 2021 |
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Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
C Crewe, JB Funcke, S Li, N Joffin, CM Gliniak, AL Ghaben, YA An, HA Sadek, R Gordillo, Y Akgul, S Chen, D Samovski, P Fischer-Posovszky, CM Kusminski, S Klein, PE Scherer |
Cell Metabolism | 2021 |
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Analysis of predictors of adherent perinephric fat and its impact on perioperative outcomes in laparoscopic partial nephrectomy: a retrospective case–control study
L Fang, H Li, T Zhang, R Liu, T Zhang, L Bi, D Xie, Y Wang, D Yu |
World journal of surgical oncology | 2021 |
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Pericoronary adipose tissue attenuation assessed by dual-layer spectral detector computed tomography is a sensitive imaging marker of high-risk plaques
X Chen, Y Dang, H Hu, S Ma, Y Ma, K Wang, T Liu, X Lu, Y Hou |
Quantitative imaging in medicine and surgery | 2021 |
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Adipoclast: a multinucleated fat-eating macrophage
A Olona, S Mukhopadhyay, C Hateley, FO Martinez, S Gordon, J Behmoaras |
BMC Biology | 2021 |
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The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice
Y Liu, Y Li, J Liang, Z Sun, Q Wu, Y Liu, C Sun |
International journal of molecular sciences | 2021 |
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Epicardial adipose tissue radiodensity is associated with all-cause mortality in patients undergoing hemodialysis
SS Kwon, K Choi, BD Nam, H Lee, NJ Cho, BW Park, H Kim, H Noh, JS Jeon, DC Han, S Oh, SH Kwon |
Scientific Reports | 2021 |
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Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults
EC Gallegos-Cabriales, E Rodriguez-Ayala, HA Laviada-Molina, EJ Nava-Gonzalez, RA Salinas-Osornio, L Orozco, I Leal-Berumen, JC Castillo-Pineda, L Gonzalez-Lopez, C Escudero-Lourdes, J Cornejo-Barrera, F Escalante-Araiza, EE Huerta-Avila, FA Buenfil-Rello, VG Peschard, E Silva, RA Veloz-Garza, A Martinez-Hernandez, FM Barajas-Olmos, F Molina-Segui, L Gonzalez-Ramirez, RD Arjona-Villicaña, VM Hernandez-Escalante, JF Gaytan-Saucedo, Z Vaquera, M Acebo-Martinez, A Murillo-Ramirez, SP Diaz-Tena, B Figueroa-Nuñez, ME Valencia-Rendon, R Garzon-Zamora, JM Viveros-Paredes, SB Valdovinos-Chavez, AG Comuzzie, K Haack, AA Thorsell, X Han, SA Cole, RA Bastarrachea |
Biology : open access journal | 2021 |
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Deciphering the Irregular Risk of Stroke Increased by Obesity Classes: A Stratified Mendelian Randomization Study
X Zou, L Wang, L Xiao, Z Xu, T Yao, M Shen, Y Zeng, L Zhang |
Frontiers in Endocrinology | 2021 |
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Microvascular Inflammation and Cardiovascular Prevention: The Role of Microcirculation as Earlier Determinant of Cardiovascular Risk
A Mengozzi, NR Pugliese, S Taddei, S Masi, A Virdis |
High Blood Pressure & Cardiovascular Prevention | 2021 |
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Editorial: The Immunomodulatory Roles of Adipocytes
D Bradley, A Xu, W Hsueh |
Frontiers in immunology | 2021 |
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The discrepancy of aromatase expression in epicardial adipose tissue between CHD and non-CHD patients
Y Li, W Cheng, B Zhao, D Ma, X Wei, S Zhang |
CARDIOVASC J AFR | 2021 |
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The new kids on the block: emerging obesogens
Chamorro-Garcia R, Veiga-Lopez A |
Advances in pharmacology (San Diego, Calif.) | 2021 |
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Gut microbiota modulates weight gain in mice after discontinued smoke exposure.
Fluhr L, Mor U, Kolodziejczyk AA, Dori-Bachash M, Leshem A, Itav S, Cohen Y, Suez J, Zmora N, Moresi C, Molina S, Ayalon N, Valdés-Mas R, Hornstein S, Karbi H, Kviatcovsky D, Livne A, Bukimer A, Eliyahu-Miller S, Metz A, Brandis A, Mehlman T, Kuperman Y, Tsoory M, Stettner N, Harmelin A, Shapiro H, Elinav E |
Nature | 2021 |
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The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern |
Journal of Clinical Investigation | 2020 |
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X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity
Jenny C. Link, Carrie B. Wiese, Xuqi Chen, Rozeta Avetisyan, Emilio Ronquillo, Feiyang Ma, Xiuqing Guo, Jie Yao, Matthew Allison, Yii-Der I. Chen, Jerome I. Rotter, Julia S. El-Sayed Moustafa, Kerrin S. Small, Shigeki Iwase, Matteo Pellegrini, Laurent Vergnes, Arthur P. Arnold, Karen Reue |
Journal of Clinical Investigation | 2020 |
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Decreased adipose tissue oxygenation associates with insulin resistance in people with obesity
Vincenza Cifarelli, Scott Beeman, Gordon I. Smith, Jun Yoshino, Darya Morozov, Joseph W. Beals, Brandon D. Kayser, Jeramie D. Watrous, Mohit Jain, Bruce W. Patterson, Samuel Klein |
Journal of Clinical Investigation | 2020 |
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Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure
A Divoux, K Sandor, D Bojcsuk, F Yi, ME Hopf, JS Smith, BL Balint, TF Osborne, SR Smith |
Journal of the Endocrine Society | 2020 |
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The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
M Clemente-Postigo, A Tinahones, RE Bekay, MM Malagón, FJ Tinahones |
Metabolites | 2020 |
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Adipose Tissue Immunomodulation: A Novel Therapeutic Approach in Cardiovascular and Metabolic Diseases
I AlZaim, SH Hammoud, H Al-Koussa, A Ghazi, AH Eid, AF El-Yazbi |
Frontiers in Cardiovascular Medicine | 2020 |
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Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease
M Lino, D Ngai, A Liu, A Mohabeer, C Harper, L Caruso, SA Schroer, F Fu, T McKee, A Giacca, M Woo, MP Bendeck |
Molecular Metabolism | 2020 |
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Osteopontin: The Molecular Bridge between Fat and Cardiac–Renal Disorders
E Vianello, M Kalousová, E Dozio, L Tacchini, T Zima, MM Romanelli |
International journal of molecular sciences | 2020 |
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Adipose tissue in health and disease
I Harvey, A Boudreau, JM Stephens |
Open Biology | 2020 |
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Suppressing adipocyte inflammation promotes insulin resistance in mice
Q Zhu, YA An, M Kim, Z Zhang, S Zhao, Y Zhu, IW Asterholm, CM Kusminski, PE Scherer |
Molecular Metabolism | 2020 |
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Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity
S Yoshino, Y Iwasaki, S Matsumoto, T Satoh, A Ozawa, E Yamada, S Kakizaki, JA Trejo, Y Uchiyama, M Yamada, M Mori |
Scientific Reports | 2020 |
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Metabolic Inflammation and Insulin Resistance in Obesity
H Wu, CM Ballantyne |
Circulation research | 2020 |
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Higher Mast Cell Accumulation in Human Adipose Tissues Defines Clinically Favorable Obesity Sub-Phenotypes
N Goldstein, Y Kezerle, Y Gepner, Y Haim, T Pecht, R Gazit, V Polischuk, IF Liberty, B Kirshtein, R Shaco-Levy, M Blüher, A Rudich |
Cells | 2020 |
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Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
MK DeBari, RD Abbott |
International journal of molecular sciences | 2020 |
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YAP and TAZ protect against white adipocyte cell death during obesity
L Wang, SP Wang, Y Shi, R Li, S Günther, YT Ong, M Potente, Z Yuan, E Liu, S Offermanns |
Nature Communications | 2020 |
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Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease
D Margină, A Ungurianu, C Purdel, GM Nițulescu, D Tsoukalas, E Sarandi, M Thanasoula, TI Burykina, F Tekos, A Buha, D Nikitovic, D Kouretas, AM Tsatsakis |
Food and Chemical Toxicology | 2020 |
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Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy
SS Faria, LH Corrêa, GS Heyn, LP de Sant'Ana, R das Neves Almeida, KG Magalhães |
Journal of Breast Cancer | 2020 |
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Das Fettgewebe im Fokus des Immunsystems: adipositasassoziierte Inflammation
P Fischer-Posovszky, P Möller |
Der Pathologe | 2020 |
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Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice
E Lontchi-Yimagou, S Kang, A Goyal, K Zhang, JY You, M Carey, S Jain, S Bhansali, S Kehlenbrink, P Guo, ED Rosen, P Kishore, M Hawkins |
Molecular Metabolism | 2020 |
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Mammary Adipose Tissue Control of Breast Cancer Progression: Impact of Obesity and Diabetes
V DEsposito, MR Ambrosio, M Giuliano, S Cabaro, C Miele, F Beguinot, P Formisano |
Frontiers in Oncology | 2020 |
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Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation
AR Pessentheiner, GM Ducasa, PL Gordts |
Frontiers in immunology | 2020 |
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Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages
K McKernan, M Varghese, R Patel, K Singer |
Adipocyte | 2020 |
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Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children
MD Ordóñez-Díaz, JL Pérez-Navero, K Flores-Rojas, J Olza-Meneses, MC Muñoz-Villanueva, CM Aguilera-García, M Gil-Campos |
Frontiers in Pediatrics | 2020 |
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Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity
TD Dagpo, CJ Nolan, V Delghingaro-Augusto |
Cells | 2020 |
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Impact of weight loss and partial weight regain on immune cell and inflammatory markers in adipose tissue in male mice
AT Sougiannis, BN VanderVeen, TL Cranford, RT Enos, KT Velazquez, S McDonald, JE Bader, I Chatzistamou, D Fan, EA Murphy |
Journal of applied physiology | 2020 |
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Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice
SP Wang, S Cao, M Arhatte, D Li, Y Shi, S Kurz, J Hu, L Wang, J Shao, A Atzberger, Z Wang, C Wang, W Zang, I Fleming, N Wettschureck, E Honoré, S Offermanns |
Nature Communications | 2020 |
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Metabolically Healthy Obesity
M Blüher |
Endocrine reviews | 2020 |
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Facial Fat Fitness: A New Paradigm to Understand Facial Aging and Aesthetics
I Galanin, C Nicu, JI Tower |
Aesthetic Plastic Surgery | 2020 |
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Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
Ludger Scheja, Joerg Heeren |
Handbook of experimental pharmacology | 2020 |
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Developmental and functional heterogeneity of thermogenic adipose tissue
HB Ruan, F Liu |
Journal of Molecular Cell Biology | 2020 |
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Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473
KV Tran, EL Brown, T DeSouza, NZ Jespersen, C Nandrup-Bus, Q Yang, Z Yang, A Desai, SY Min, R Rojas-Rodriguez, M Lundh, A Feizi, H Willenbrock, TJ Larsen, MC Severinsen, K Malka, AM Mozzicato, AS Deshmukh, B Emanuelli, BK Pedersen, T Fitzgibbons, C Scheele, S Corvera, S Nielsen |
Nature metabolism | 2020 |
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Type I interferon sensing unlocks dormant adipocyte inflammatory potential
CC Chan, MS Damen, ME Moreno-Fernandez, TE Stankiewicz, M Cappelletti, PC Alarcon, JR Oates, JR Doll, R Mukherjee, X Chen, R Karns, MT Weirauch, MA Helmrath, TH Inge, S Divanovic |
Nature Communications | 2020 |
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Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues
Z Jia, F Yue, X Chen, N Narayanan, J Qiu, SA Syed, AN Imbalzano, M Deng, P Yu, C Hu, S Kuang |
Advanced Science | 2020 |
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Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity
X Unamuno, J Gómez-Ambrosi, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán |
Journal of Clinical Medicine | 2020 |
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Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
S Francque, G Szabo, MF Abdelmalek, CD Byrne, K Cusi, JF Dufour, M Roden, F Sacks, F Tacke |
Nature Reviews Gastroenterology & Hepatology | 2020 |
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Vitamin D regulation of adipogenesis and adipose tissue functions
H Nimitphong, E Park, MJ Lee |
Nutrition Research and Practice | 2020 |
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Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development
M Varela-Guruceaga, E Belaidi, L Lebeau, E Aka, R Andriantsitohaina, S Giorgetti-Peraldi, C Arnaud, SL Lay |
Frontiers in physiology | 2020 |
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Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity
AG Izquierdo, MC Carreira, G Rodriguez-Carnero, A Fernandez-Quintela, AM Sueiro, MA Martinez-Olmos, G Guzman, DD Luis, MA Pinhel, CF Nicoletti, CB Nonino, FJ Ortega, MP Portillo, JM Fernandez-Real, FF Casanueva, AB Crujeiras |
International Journal of Obesity | 2020 |
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Adipokine Resistin Levels at Time of Pediatric Crohn Disease Diagnosis Predict Escalation to Biologic Therapy
JA Kurowski, JP Achkar, R Gupta, I Barbur, TL Bonfield, S Worley, EM Remer, C Fiocchi, SE Viswanath, MH Kay |
Inflammatory Bowel Diseases | 2020 |
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Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study
E Rodriguez-Ayala, EC Gallegos-Cabrales, L Gonzalez-Lopez, HA Laviada-Molina, RA Salinas-Osornio, EJ Nava-Gonzalez, I Leal-Berumen, C Escudero-Lourdes, F Escalante-Araiza, FA Buenfil-Rello, VG Peschard, A Laviada-Nagel, E Silva, RA Veloz-Garza, A Martinez-Hernandez, FM Barajas-Olmos, F Molina-Segui, L Gonzalez-Ramirez, R Espadas-Olivera, R Lopez-Muñoz, RD Arjona-Villicaña, VM Hernandez-Escalante, ME Rodriguez-Arellano, JF Gaytan-Saucedo, Z Vaquera, M Acebo-Martinez, J Cornejo-Barrera, HQ Andrea, JC Castillo-Pineda, A Murillo-Ramirez, SP Diaz-Tena, B Figueroa-Nuñez, ME Valencia-Rendon, R Garzon-Zamora, JM Viveros-Paredes, J Ángeles-Chimal, JS Tapia, JM Remes-Troche, SB Valdovinos-Chavez, EE Huerta-Avila, JC Lopez-Alvarenga, AG Comuzzie, K Haack, X Han, L Orozco, S Weintraub, JW Kent, SA Cole, RA Bastarrachea |
Adipocyte | 2020 |
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Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study
FZ Fouani, R Fadaei, N Moradi, Z Zandieh, S Ansaripour, MS Yekaninejad, A Vatannejad, M Mahmoudi, F Qu |
PloS one | 2020 |
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Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
MT Kaartinen, M Arora, S Heinonen, A Rissanen, J Kaprio, KH Pietiläinen |
International journal of molecular sciences | 2020 |
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Obesity and ethnicity alter gene expression in skin
JM Walker, S Garcet, JO Aleman, CE Mason, D Danko, D Butler, S Zuffa, JR Swann, J Krueger, JL Breslow, PR Holt |
Scientific Reports | 2020 |
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Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis
J Zhang, J Ma, X Zhou, S Hu, L Ge, J Sun, P Li, K Long, L Jin, Q Tang, L Liu, X Li, S Shuai, M Li |
Frontiers in Genetics | 2020 |
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Adipose tissue depot‐specific intracellular and extracellular cues contributing to insulin resistance in obese individuals
R GuzmánRuiz, C TerceroAlcázar, Y RabanalRuiz, A DíazRuiz, RE Bekay, OA RangelZuñiga, MC NavarroRuiz, L Molero, A Membrives, JF RuizRabelo, A Pandit, J LópezMiranda, FJ Tinahones, MM Malagón |
The FASEB Journal | 2020 |
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Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
EK Oikonomou, M Siddique, C Antoniades |
Cardiovascular Research | 2020 |
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The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?
SA Cole, HA Laviada-Molina, JM Serres-Perales, E Rodriguez-Ayala, RA Bastarrachea |
Pathogens | 2020 |
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Myocardial Infarction Associates With a Distinct Pericoronary Adipose Tissue Radiomic Phenotype
A Lin, M Kolossváry, J Yuvaraj, S Cadet, PA McElhinney, C Jiang, N Nerlekar, SJ Nicholls, PJ Slomka, P Maurovich-Horvat, DT Wong, D Dey |
JACC: Cardiovascular Imaging | 2020 |
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The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
F Wang, S Chen, L Ren, Y Wang, Z Li, T Song, H Zhang, Q Yang |
Frontiers in pharmacology | 2020 |
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Serum C‐X‐C motif chemokine ligand 14 levels are associated with serum C‐peptide and fatty liver index in type 2 diabetes mellitus patients
Y Matsushita, Y Hasegawa, N Takebe, K Onodera, M Shozushima, T Oda, K Nagasawa, H Honma, K Nata, A Sasaki, Y Ishigaki |
Journal of Diabetes Investigation | 2020 |
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Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans
CW Ha, A Martin, GD Sepich-Poore, B Shi, Y Wang, K Gouin, G Humphrey, K Sanders, Y Ratnayake, KS Chan, G Hendrick, JR Caldera, C Arias, JE Moskowitz, SJ Sui, S Yang, D Underhill, MJ Brady, S Knott, K Kaihara, MJ Steinbaugh, H Li, DP McGovern, R Knight, P Fleshner, S Devkota |
Cell | 2020 |
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miR-146a regulates insulin sensitivity via NPR3
J Roos, M Dahlhaus, JB Funcke, M Kustermann, G Strauss, D Halbgebauer, E Boldrin, K Holzmann, P Möller, BM Trojanowski, B Baumann, KM Debatin, M Wabitsch, P Fischer-Posovszky |
Cellular and Molecular Life Sciences | 2020 |
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Adipose Tissue as Pain Generator in the Lower Back and Lower Extremity: Application in Musculoskeletal Medicine
Lee SW, Van Dien C, Won SJ |
2020 | |
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What lipodystrophies teach us about the metabolic syndrome
Jake P. Mann, David Savage |
Journal of Clinical Investigation | 2019 |
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27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling
A Asghari, T Ishikawa, S Hiramitsu, WR Lee, J Umetani, L Bui, KS Korach, M Umetani |
Endocrinology | 2019 |
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Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation
P Petrus, TL Fernandez, MM Kwon, JL Huang, V Lei, NS Safikhan, S Karunakaran, DJ O'Shannessy, X Zheng, SB Catrina, E Albone, J Laine, K Virtanen, SM Clee, TJ Kieffer, C Noll, AC Carpentier, JD Johnson, M Rydén, EM Conway |
EBioMedicine | 2019 |
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Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans
J Yoshino, BW Patterson, S Klein |
Obesity | 2019 |
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Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity
YA An, C Crewe, IW Asterholm, K Sun, S Chen, F Zhang, M Shao, JB Funcke, Z Zhang, L Straub, J Yoshino, S Klein, CM Kusminski, PE Scherer |
2019 | |
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Recent advances in managing/understanding the metabolic syndrome
CA Aguilar-Salinas, T Viveros-Ruiz |
F1000Research | 2019 |
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Soluble CD14 and CD14 Variants, Other Inflammatory Markers, and Glucose Dysregulation in Older Adults: The Cardiovascular Health Study
SG Shitole, ML Biggs, AP Reiner, KJ Mukamal, L Djoussé, J H., JI Barzilay, RP Tracy, D Siscovick, JR Kizer |
Diabetes care | 2019 |
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Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
JB Funcke, PE Scherer |
Journal of lipid research | 2019 |
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A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake
J Holland, J Sorrell, E Yates, K Smith, S Arbabi, M Arnold, M Rivir, R Morano, J Chen, X Zhang, R Dimarchi, SC Woods, J Sanchez-Gurmaches, E Wohleb, D Perez-Tilve |
Cell Reports | 2019 |
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The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Q Wang, VP Sharma, H Shen, Y Xiao, Q Zhu, X Xiong, L Guo, L Jiang, K Ohta, S Li, H Shi, L Rui, JD Lin |
2019 | |
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The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren |
Nature Reviews Endocrinology | 2019 |
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Adipogenesis: A Necessary but Harmful Strategy
ME Hafidi, M Buelna-Chontal, F Sánchez-Muñoz, R Carbó |
International journal of molecular sciences | 2019 |
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Unknown actor in adipose tissue metabolism hiding in plain sight
S Collins |
Proceedings of the National Academy of Sciences | 2019 |
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Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet
T da Silva Mendes de Farias, RI da Paixao, MM Cruz, RD da Cunha de Sa, J de Jesus Simão, VJ Antraco, MI Alonso-Vale |
Cells | 2019 |
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Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
C Scheele, C Wolfrum |
Endocrine reviews | 2019 |
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NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
X Unamuno, J Gómez-Ambrosi, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán |
Cellular and Molecular Immunology | 2019 |
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Serum Amyloid P and a Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin Ligand Inhibit High-Fat Diet–Induced Adipose Tissue and Liver Inflammation and Steatosis in Mice
D Pilling, N Cox, MA Thomson, TR Karhadkar, RH Gomer |
The American Journal of Pathology | 2019 |
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Oxygenation of adipose tissue: A human perspective
IG Lempesis, RL Meijel, KN Manolopoulos, GH Goossens |
Acta physiologica (Oxford, England) | 2019 |
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Metabolically Healthy Obesity and Bariatric Surgery
AF Cătoi, L Busetto |
Obesity Surgery | 2019 |
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Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
W Yang, L Liu, Y Wei, C Fang, F Zhou, J Chen, Q Han, M Huang, X Tan, Q Liu, Q Pan, L Zhang, X Lei, L Li |
Endocrine Connections | 2019 |
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Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
A Chakraborty, S Barajas, GM Lammoglia, AJ Reyna, TS Morley, JA Johnson, PE Scherer, JM Rutkowski |
The American Journal of Pathology | 2019 |
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Characterization of subcutaneous and omental adipose tissue in patients with obesity and with different degrees of glucose impairment
A Belligoli, C Compagnin, M Sanna, F Favaretto, R Fabris, L Busetto, M Foletto, CD Prà, R Serra, L Prevedello, CD Re, R Bardini, C Mescoli, M Rugge, P Fioretto, S Conci, S Bettini, G Milan, R Vettor |
Scientific Reports | 2019 |
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Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution
QA Wang, PE Scherer |
Journal of Mammary Gland Biology and Neoplasia | 2019 |
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Effect of Sleeve Gastrectomy on Angiogenesis and Adipose Tissue Health in an Obese Animal Model of Type 2 Diabetes
H Eickhoff, T Rodrigues, I Neves, D Marques, D Ribeiro, S Costa, R Seiça, P Matafome |
Obesity Surgery | 2019 |
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Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk
D Bradley, A Blaszczak, Z Yin, J Liu, JJ Joseph, V Wright, K Anandani, B Needleman, S Noria, D Renton, M Yearsley, ST Wong, WA Hsueh |
Diabetes care | 2019 |
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Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
G Frühbeck, V Catalán, A Rodríguez, B Ramírez, S Becerril, J Salvador, I Colina, J Gómez-Ambrosi |
Nutrients | 2019 |
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Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to Tumorigenesis
MD Cornò, A Baldassarre, E Calura, L Conti, P Martini, C Romualdi, R Varì, B Scazzocchio, M D'Archivio, A Masotti, S Gessani |
Frontiers in immunology | 2019 |
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Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue
S AL-Ghadban, W Cromer, M Allen, C Ussery, M Badowski, D Harris, KL Herbst |
Journal of Obesity | 2019 |
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Function and Mechanism of Long Noncoding RNAs in Adipocyte Biology
L Sun, JD Lin |
Diabetes | 2019 |
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Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging
S Kim, ES Lee, SW Lee, YH Kim, CH Lee, DG Jo, SH Kim |
Proceedings of the National Academy of Sciences | 2019 |
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GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity
EO List, DE Berryman, M Buchman, EA Jensen, K Funk, S Duran-Ortiz, Y Qian, JA Young, J Slyby, S McKenna, JJ Kopchick |
Endocrinology | 2019 |
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A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
EK Oikonomou, MC Williams, CP Kotanidis, MY Desai, M Marwan, AS Antonopoulos, KE Thomas, S Thomas, I Akoumianakis, LM Fan, S Kesavan, L Herdman, A Alashi, EH Centeno, M Lyasheva, BP Griffin, SD Flamm, C Shirodaria, N Sabharwal, A Kelion, MR Dweck, EJ Beek, J Deanfield, JC Hopewell, S Neubauer, KM Channon, S Achenbach, DE Newby, C Antoniades |
European Heart Journal | 2019 |
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The effects of growth hormone on adipose tissue: old observations, new mechanisms
JJ Kopchick, DE Berryman, V Puri, KY Lee, JO Jorgensen |
Nature Reviews Endocrinology | 2019 |
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Increased oxidative stress, inflammation and fibrosis in perirenal adipose tissue of patients with cortisol-producing adenoma
C Wu, H Zhang, J Zhang, H Zhang, Y Zeng, S Fang, P Li, Y Zhang, X Lin, L Wang, Y Xue, M Guan |
Adipocyte | 2019 |
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The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity
Keisuke Yanagida, Hidemitsu Igarashi, Daisuke Yasuda, Daiki Kobayashi, Takayo Ohto-Nakanishi, Noriyuki Akahoshi, Atsushi Sekiba, Tsudoi Toyoda, Tomoko Ishijima, Yuji Nakai, Nobuhiro Shojima, Naoto Kubota, Keiko Abe, Takashi Kadowaki, Satoshi Ishii, Takao Shimizu |
JCI Insight | 2018 |
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The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health
XY Zhao, S Li, JL DelProposto, T Liu, L Mi, C Porsche, X Peng, CN Lumeng, JD Lin |
Molecular Metabolism | 2018 |
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Genes that make you fat, but keep you healthy
RJ Loos, TO Kilpeläinen |
Journal of Internal Medicine | 2018 |
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Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice
X Sun, K Gupta, B Wu, D Zhang, B Yuan, X Zhang, HC Chiang, C Zhang, TJ Curiel, MP Bendeck, S Hursting, Y Hu, R Li |
The Journal of biological chemistry | 2018 |
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The Vasculature in Prediabetes
DH Wasserman, TJ Wang, NJ Brown |
Circulation research | 2018 |
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Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth
M Rudnicki, G Abdifarkosh, E Nwadozi, SV Ramos, A Makki, DM Sepa-Kishi, RB Ceddia, CG Perry, E Roudier, TL Haas |
eLife | 2018 |
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Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue
M Jager, MJ Lee, C Li, SR Farmer, SK Fried, MD Layne, C Woeller |
PloS one | 2018 |
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Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Y Igarashi, A Nawaz, T Kado, M Bilal, T Kuwano, S Yamamoto, M Sasahara, X Jiuxiang, A Inujima, K Koizumi, J Imura, N Shibahara, I Usui, S Fujisaka, K Tobe |
Scientific Reports | 2018 |
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The obese adipose tissue microenvironment in cancer development and progression
DF Quail, AJ Dannenberg |
Nature Reviews Endocrinology | 2018 |
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TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice
C Griffin, L Eter, N Lanzetta, S Abrishami, M Varghese, K McKernan, L Muir, J Lane, CN Lumeng, K Singer |
The Journal of biological chemistry | 2018 |
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Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction: Microfragmented Adipose Tissue Secretory Activity
B Vezzani, I Shaw, H Lesme, L Yong, N Khan, C Tremolada, B Péault |
Stem Cells Translational Medicine | 2018 |
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Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies
Y Yuan, N Ran, L Xiong, G Wang, X Guan, Z Wang, Y Guo, Z Pang, K Fang, J Lu, C Zhang, R Zheng, J Zheng, J Ma, F Wang |
Journal of Immunology Research | 2018 |
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The many secret lives of adipocytes: implications for diabetes
PE Scherer |
Diabetologia | 2018 |
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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
Y Hasegawa, K Ikeda, Y Chen, DL Alba, D Stifler, K Shinoda, T Hosono, P Maretich, Y Yang, Y Ishigaki, J Chi, P Cohen, SK Koliwad, S Kajimura |
Cell Metabolism | 2018 |
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A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
JA Timmons, PJ Atherton, O Larsson, S Sood, IO Blokhin, RJ Brogan, CH Volmar, AR Josse, C Slentz, C Wahlestedt, SM Phillips, BE Phillips, IJ Gallagher, WE Kraus |
Nucleic Acids Research | 2018 |
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Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis
A Olona, X Terra, JH Ko, C Grau-Bové, M Pinent, A Ardevol, AG Diaz, A Moreno-Moral, M Edin, D Bishop-Bailey, DC Zeldin, TJ Aitman, E Petretto, M Blay, J Behmoaras |
Molecular Metabolism | 2018 |
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Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet
M Rudnicki, G Abdifarkosh, O Rezvan, E Nwadozi, E Roudier, TL Haas |
Frontiers in physiology | 2018 |
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A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome
M Kokosar, A Benrick, A Perfilyev, E Nilsson, T Källman, C Ohlsson, C Ling, E Stener-Victorin |
Scientific Reports | 2018 |
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Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome
MJ Kraakman, HL Kammoun, D Dragoljevic, A Al-Sharea, MK Lee, MC Flynn, CJ Stolz, AA Guirguis, GI Lancaster, J Chin-Dusting, DJ Curtis, AJ Murphy |
Haematologica | 2018 |
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Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction
J Monks, DJ Orlicky, AL Stefanski, AE Libby, ES Bales, MC Rudolph, GC Johnson, VD Sherk, MR Jackman, K Williamson, NE Carlson, PS MacLean, JL McManaman |
Nutrition and Diabetes | 2018 |
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Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis
N Denton, KE Pinnick, F Karpe |
Molecular Metabolism | 2018 |
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Endothelium-specific CYP2J2 overexpression attenuates age-related insulin resistance
Y Yang, R Dong, Z Chen, D Hu, M Fu, Y Tang, DW Wang, X Xu, L Tu |
Aging Cell | 2018 |
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Adipose tissue's rapid response team
SK Fried |
Journal of leukocyte biology | 2018 |
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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
C Crewe, N Joffin, JM Rutkowski, M Kim, F Zhang, DA Towler, R Gordillo, PE Scherer |
Cell | 2018 |
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Impaired Glucocorticoid Suppression of TGFβ Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis
MJ Lee, RT Pickering, V Shibad, Y Wu, K Karastergiou, M Jager, MD Layne, SK Fried |
Diabetes | 2018 |
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Determinants of body fat distribution in humans may provide insight about obesity-related health risks
AP Frank, R de Souza Santos, BF Palmer, DJ Clegg |
Journal of lipid research | 2018 |
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Inflammatory mechanisms linking obesity and metabolic disease
Alan R. Saltiel, Jerrold Olefsky |
Journal of Clinical Investigation | 2017 |
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Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance
DS Lark, DH Wasserman |
F1000Research | 2017 |
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Growth Hormone’s Effect on Adipose Tissue: Quality versus Quantity
D Berryman, E List |
International journal of molecular sciences | 2017 |
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Warming the mouse to model human diseases
K Ganeshan, A Chawla |
Nature Reviews Endocrinology | 2017 |
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Regulation of immunometabolism in adipose tissue
M Kumari, J Heeren, L Scheja |
Seminars in Immunopathology | 2017 |
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Normalization of adiponectin concentrations by leptin replacement in ob/ob mice is accompanied by reductions in systemic oxidative stress and inflammation
G Frühbeck, V Catalán, A Rodríguez, B Ramírez, S Becerril, P Portincasa, J Gómez-Ambrosi |
Scientific Reports | 2017 |
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Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
G Frühbeck, V Catalán, A Rodríguez, B Ramírez, S Becerril, J Salvador, P Portincasa, I Colina, J Gómez-Ambrosi |
Scientific Reports | 2017 |
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Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
M Alcalá, M Calderon-Dominguez, E Bustos, P Ramos, N Casals, D Serra, M Viana, L Herrero |
Scientific Reports | 2017 |
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Exploring the Crosstalk between Adipose Tissue and the Cardiovascular System
I Akoumianakis, N Akawi, C Antoniades |
Korean Circulation Journal | 2017 |
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miR155 deficiency aggravates high‐fat diet‐induced adipose tissue fibrosis in male mice
KT Velázquez, RT Enos, MS Carson, TL Cranford, JE Bader, AT Sougiannis, C Pritchett, D Fan, JA Carson, EA Murphy |
Physiological Reports | 2017 |
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Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders
Z Chen, GX Wang, SL Ma, DY Jung, H Ha, T Altamimi, XY Zhao, L Guo, P Zhang, CR Hu, JX Cheng, GD Lopaschuk, JK Kim, JD Lin |
Molecular Metabolism | 2017 |
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ColXV promotes adipocyte differentiation via inhibiting DNA methylation and cAMP/PKA pathway in mice
G Liu, M Li, Y Xu, S Wu, M Saeed, C Sun |
Oncotarget | 2017 |
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The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts
N Arrighi, K Lypovetska, C Moratal, S Giorgetti-Peraldi, CA Dechesne, C Dani, P Peraldi |
Scientific Reports | 2017 |
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Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk
G Frühbeck, V Catalán, A Rodríguez, J Gómez-Ambrosi |
Adipocyte | 2017 |
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