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Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

Ping-yuan Wang, … , Antonio Tito Fojo, Paul M. Hwang

Ping-yuan Wang, … , Antonio Tito Fojo, Paul M. Hwang

Published November 21, 2016
Citation Information: J Clin Invest. 2017;127(1):132-136. https://doi.org/10.1172/JCI88668.

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Citations to this article (32)

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Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis Li-Harms X, Lu J, Fukuda Y, Lynch J, Sheth A, Pareek G, Kaminski MM, Ross HS, Wright CW, Smith AL, Wu H, Wang YD, Valentine M, Neale G, Vogel P, Pounds S, Schuetz JD, Ni M, Kundu M	Science Advances	2025
Cancer Precision-Prevention trial of Metformin in adults with Li Fraumeni syndrome (MILI) undergoing yearly MRI surveillance: a randomised controlled trial protocol. Dixon-Zegeye M, Shaw R, Collins L, Perez-Smith K, Ooms A, Qiao M, Pantziarka P, Izatt L, Tischkowitz M, Harrison RE, George A, Woodward ER, Lord S, Hawkes L, Evans DG, Franklin J, Hanson H, Blagden SP	Trials	2024
Ianus Bifrons: The Two Faces of Metformin. Goglia U, Hasballa I, Teti C, Boschetti M, Ferone D, Albertelli M	Cancers	2024
Clinical and genetic characteristics of carriers of the TP53 c.541C > T, p.Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent. Arnon J, Zick A, Maoz M, Salaymeh N, Gugenheim A, Marouani M, Mor E, Hamburger T, Saadi N, Elia A, Ganz G, Fahham D, Meirovitz A, Kadouri L, Meiner V, Yablonski-Peretz T, Shkedi-Rafid S	Familial Cancer	2024
Chronic obesity does not alter cancer survival in Tp53R270H/+ mice Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA	bioRxiv	2024
Li–Fraumeni Syndrome: Narrative Review Through a Case Report with Ten Years of Primary Tumor Remission Associated with Sechium H387 07 Supplementation Amador-Gómez AI, Aguiñiga-Sánchez I, Mendoza-Núñez VM, Cadena-Iñiguez J, Romero-López E, Santiago-Osorio E	International Journal of Molecular Sciences	2024
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic? Lord SR, Harris AL	British Journal of Cancer	2023
Willingness of individuals with Li-Fraumeni syndrome to participate in a cancer prevention trial: a survey study. Struewe FJ, Schott S, de Zwaan M, Kratz CP	Familial Cancer	2023
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G	Nature Communications	2023
Inhibiting the Priming for Cancer in Li-Fraumeni Syndrome P Pantziarka, S Blagden	Cancers	2022
Li–Fraumeni Syndrome: Mutation of TP53 Is a Biomarker of Hereditary Predisposition to Tumor: New Insights and Advances in the Treatment Rocca V, Blandino G, D\u2019Antona L, Iuliano R, Di Agostino S	Cancers	2022
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Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells S Chen, CC Tjin, X Gao, Y Xue, H Jiao, R Zhang, M Wu, Z He, J Ellman, Y Ha	Proceedings of the National Academy of Sciences	2021
Reducing Fatty Acid Oxidation Improves Cancer-free Survival in a Mouse Model of Li-Fraumeni Syndrome PY Wang, J Ma, J Li, MF Starost, MJ Wolfgang, K Singh, M Pirooznia, JG Kang, PM Hwang	Cancer prevention research (Philadelphia, Pa.)	2020
Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome FL Walcott, PY Wang, CM Bryla, RD Huffstutler, N Singh, MN Pollak, PP Khincha, SA Savage, PL Mai, KW Dodd, PM Hwang, AT Fojo, CM Annunziata		2020
Tumour predisposition and cancer syndromes as models to study gene–environment interactions M Carbone, ST Arron, B Beutler, A Bononi, W Cavenee, JE Cleaver, CM Croce, A DAndrea, WD Foulkes, G Gaudino, JL Groden, EP Henske, ID Hickson, PM Hwang, RD Kolodner, TW Mak, D Malkin, RJ Monnat, F Novelli, HI Pass, JH Petrini, LS Schmidt, H Yang	Nature Reviews Cancer	2020
A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53 JG Kang, CU Lago, JE Lee, JH Park, MP Donnelly, MF Starost, C Liu, J Kwon, AC Noguchi, K Ge, P Wang, PM Hwang	Cell Reports	2020
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits MD Giovannantonio, BH Harris, P Zhang, I Kitchen-Smith, L Xiong, N Sahgal, G Stracquadanio, M Wallace, S Blagden, Simon, D Harris, AH Harris, FM Buffa, GL Bond	Journal of medical genetics	2020
DNA damage and mitochondria in cancer and aging J Patel, BA Baptiste, E Kim, M Hussain, DL Croteau, VA Bohr	Carcinogenesis	2020
p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities J Li, P Wang, NA Long, J Zhuang, DA Springer, J Zou, Y Lin, CK Bleck, JH Park, JG Kang, PM Hwang	Proceedings of the National Academy of Sciences	2019
Modeling the prevalent germline TP53 R337H mutation in mouse JH Park, PY Wang, PM Hwang	Oncotarget	2019
Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model MP Donnelly, J Li, PM Hwang		2019
Window of opportunity clinical trial designs to study cancer metabolism F Aroldi, S R.	British Journal of Cancer	2019
The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer HR Fernandez, SM Gadre, M Tan, GT Graham, R Mosaoa, MS Ongkeko, KA Kim, RB Riggins, E Parasido, I Petrini, S Pacini, A Cheema, R Varghese, HW Ressom, Y Zhang, C Albanese, A Üren, M Paige, G Giaccone, ML Avantaggiati	Cell Death and Differentiation	2018
Efficacy of oral metformin in a patient with metastatic adrenocortical carcinoma: Examination of mechanisms and therapeutic implications RD Peixoto, LM Gomes, TT Sousa, DJ Racy, M Shigenaga, RA Nagourney	Rare tumors	2018
Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers H Cheng, X Yang, H Si, AD Saleh, W Xiao, J Coupar, SM Gollin, RL Ferris, N Issaeva, WG Yarbrough, ME Prince, TE Carey, CV Waes, Z Chen	Cell Reports	2018
Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy G Lonetto, G Koifman, A Silberman, A Attery, H Solomon, S Levin-Zaidman, N Goldfinger, Z Porat, A Erez, V Rotter	Cell Death and Differentiation	2018
Mutant p53 as a guardian of the cancer cell F Mantovani, L Collavin, GD Sal	Cell Death and Differentiation	2018
Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism M Eriksson, G Ambroise, AT Ouchida, AL Queiroz, D Smith, A Gimenez-Cassina, MP Iwanicki, PA Muller, E Norberg, H Vakifahmetoglu-Norberg	Molecular and cellular biology	2017
The effects of metformin on gut microbiota and the immune system as research frontiers M Pollak	Diabetologia	2017

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