Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Public T cell receptors confer high-avidity CD4 responses to HIV controllers
Daniela Benati, … , Fernando Arenzana-Seisdedos, Lisa A. Chakrabarti
Daniela Benati, … , Fernando Arenzana-Seisdedos, Lisa A. Chakrabarti
Published April 25, 2016
Citation Information: J Clin Invest. 2016;126(6):2093-2108. https://doi.org/10.1172/JCI83792.
View: Text | PDF
Research Article AIDS/HIV Article has an altmetric score of 136

Public T cell receptors confer high-avidity CD4 responses to HIV controllers

  • Text
  • PDF
Abstract

The rare patients who are able to spontaneously control HIV replication in the absence of therapy show signs of a particularly efficient cellular immune response. To identify the molecular determinants that underlie this response, we characterized the T cell receptor (TCR) repertoire directed at Gag293, the most immunoprevalent CD4 epitope in the HIV-1 capsid. HIV controllers from the ANRS CODEX cohort showed a highly skewed TCR repertoire that was characterized by a predominance of TRAV24 and TRBV2 variable genes, shared CDR3 motifs, and a high frequency of public clonotypes. The most prevalent public clonotypes generated TCRs with affinities at the higher end of values reported for naturally occurring TCRs. The high-affinity Gag293-specific TCRs were cross-restricted by up to 5 distinct HLA-DR alleles, accounting for the expression of these TCRs in HIV controllers of diverse genetic backgrounds. Transfer of these TCRs to healthy donor CD4+ T cells conferred high antigen sensitivity and polyfunctionality, thus recapitulating key features of the controller CD4 response. Transfer of a high-affinity Gag293-specific TCR also redirected CD8+ T cells to target HIV-1 capsid via nonconventional MHC II restriction. Together, these findings indicate that TCR clonotypes with superior functions are associated with HIV control. Amplification or transfer of such clonotypes may contribute to immunotherapeutic approaches aiming at a functional HIV cure.

Authors

Daniela Benati, Moran Galperin, Olivier Lambotte, Stéphanie Gras, Annick Lim, Madhura Mukhopadhyay, Alexandre Nouël, Kristy-Anne Campbell, Brigitte Lemercier, Mathieu Claireaux, Samia Hendou, Pierre Lechat, Pierre de Truchis, Faroudy Boufassa, Jamie Rossjohn, Jean-François Delfraissy, Fernando Arenzana-Seisdedos, Lisa A. Chakrabarti

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 Total
Citations: 1 2 4 8 9 6 1 4 7 1 43
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (43)

Title and authors Publication Year
HIV controllers: hope for a functional cure
Deng Z, Yan H, Lambotte O, Moog C, Su B
Frontiers in Immunology 2025
Re-centauring T cell antigen discovery around CD4(+) T cells.
Smith BE, Chan AO, Birnbaum ME
2024
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.
Kohlgruber AC, Dezfulian MH, Sie BM, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ
Nature biotechnology 2024
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
Sengupta S, Zhang J, Reed MC, Yu J, Kim A, Boronina TN, Board NL, Wrabl JO, Shenderov K, Welsh RA, Yang W, Timmons AE, Hoh R, Cole RN, Deeks SG, Siliciano JD, Siliciano RF, Sadegh-Nasseri S
Journal of Experimental Medicine 2023
Analysis of thymic generation of shared T‐cell receptor α repertoire associated with recognition of tumor antigens shows no preference for neoantigens over wild‐type antigens
Mattila J, Sormunen S, Heikkilä N, Mattila IP, Saramäki J, Arstila TP
Cancer Medicine 2023
Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells.
Zhou Y, Jadlowsky J, Baiduc C, Klattenhoff AW, Chen Z, Bennett AD, Pumphrey NJ, Jakobsen BK, Riley JL
PLoS pathogens 2023
TScan-II: A genome-scale platform for de novo identification of CD4+ T-cell epitopes
Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi A, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy S, Warner BM, Elledge SJ
Cell 2023
Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX—a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine
S Chen, Y Wong, L Yim, H Zhang, H Wang, G Lui, X Li, X Tang, L Cheng, Y Du, Q Peng, J Wang, H Kwok, H Huang, T Lau, D Chan, B Wong, L Liu, L Chakrabarti, S Lee, Z Chen, G Silvestri
Journal of virology 2022
Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry
M Claireaux, R Robinot, J Kervevan, M Patgaonkar, I Staropoli, A Brelot, A Nouël, S Gellenoncourt, X Tang, M Héry, S Volant, E Perthame, V Avettand-Fenoël, J Buchrieser, T Cokelaer, C Bouchier, L Ma, F Boufassa, S Hendou, V Libri, M Hasan, D Zucman, P de Truchis, O Schwartz, O Lambotte, L Chakrabarti
Nature Communications 2022
A nano-enhanced vaccine for metastatic melanoma immunotherapy
Salotto KE, Olson Jr WC, Pollack KE, Illendula A, Michel E, Henriques S, Fox T, Walker S, Dunlap-Brown M, Slingluff Jr CL, Kester M, Snyder HW
2022
HIV-1-infected CD4+ T cells present MHCII-restricted epitope via endogenous processing
Addison MM, Ellis GI, Leslie GJ, Zawadzky NB, Riley JL, Hoxie JA, Eisenlohr LC
Journal of immunology (Baltimore, Md. : 1950) 2022
Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study.
Frimpong A, Ofori MF, Degoot AM, Kusi KA, Gershom B, Quartey J, Kyei-Baafour E, Nguyen N, Ndifon W
Frontiers in immunology 2022
Safety and durability of AGT103-T autologous T cell therapy for HIV infection in a Phase 1 trial
Muvarak N, Li H, Lahusen T, Galvin JA, Kumar PN, Pauza CD, Bordon J
Frontiers in Medicine 2022
Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19
Ogura H, Gohda J, Lu X, Yamamoto M, Takesue Y, Son A, Doi S, Matsushita K, Isobe F, Fukuda Y, Huang TP, Ueno T, Mambo N, Murakami H, Kawaguchi Y, Inoue JI, Shirai K, Yamasaki S, Hirata JI, Ishido S
Nature Communications 2022
Elite and posttreatment controllers, two facets of HIV control.
Mastrangelo A, Banga R, Perreau M
Current Opinion in HIV and AIDS 2022
The discriminatory power of the T cell receptor
J Pettmann, A Huhn, EA Shah, MA Kutuzov, DB Wilson, ML Dustin, SJ Davis, PA van der Merwe, O Dushek
eLife 2021
Role of CD4+ T Cells in the Control of Viral Infections: Recent Advances and Open Questions
J Kervevan, LA Chakrabarti
International journal of molecular sciences 2021
Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells
K Sugata, Y Matsunaga, Y Yamashita, M Nakatsugawa, T Guo, L Halabelian, Y Ohashi, K Saso, MA Rahman, M Anczurowski, CH Wang, K Murata, H Saijo, Y Kagoya, D Ly, BD Burt, MO Butler, TW Mak, N Hirano
Nature Biotechnology 2021
Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences
DA Yohannes, K Kaukinen, K Kurppa, P Saavalainen, D Greco
BMC bioinformatics 2021
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
TH Nguyen, M Koutsakos, CE van de Sandt, JC Crawford, L Loh, S Sant, L Grzelak, EK Allen, T Brahm, EB Clemens, M Auladell, L Hensen, Z Wang, S Nüssing, X Jia, P Günther, AK Wheatley, SJ Kent, M Aban, YM Deng, KL Laurie, AC Hurt, S Gras, J Rossjohn, J Crowe, J Xu, D Jackson, LE Brown, NL Gruta, W Chen, PC Doherty, SJ Turner, TC Kotsimbos, PG Thomas, AC Cheng, K Kedzierska
Nature Communications 2021
Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort
L Plaçais, F Boufassa, C Lécuroux, E Gardiennet, V Avettand-Fenoel, A Saez-Cirion, O Lambotte, N Noël
2021
Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures
YH Teng, HS Quah, L Suteja, JM Dias, A Mupo, RJ Bashford-Rogers, GS Vassiliou, ML Chua, DS Tan, DW Lim, NG Iyer
Cancer Immunology, Immunotherapy 2021
Autophagy-dependent glutaminolysis drives superior IL21 production in HIV-1-specific CD4 T cells
H Loucif, X Dagenais-Lussier, D Avizonis, L Choinière, C Beji, L Cassin, JP Routy, JH Fritz, D Olagnier, J van Grevenynghe
Autophagy 2021
Distinct antibody profiles in HLA-B ∗ 57 + , HLA-B ∗ 57 − HIV controllers and chronic progressors
J Klingler, N Paul, G Laumond, S Schmidt, L Mayr, T Decoville, O Lambotte, B Autran, S Bahram, C Moog
AIDS 2021
HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells
S Sant, SM Quiñones-Parra, M Koutsakos, EJ Grant, T Loudovaris, SI Mannering, J Crowe, CE van de Sandt, GF Rimmelzwaan, J Rossjohn, S Gras, L Loh, TH Nguyen, K Kedzierska, S Schultz-Cherry
PLoS pathogens 2020
The Many Faces of CD4+ T Cells: Immunological and Structural Characteristics
DS Chatzileontiadou, H Sloane, AT Nguyen, S Gras, EJ Grant
International journal of molecular sciences 2020
Escherichia coli–Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn’s Disease
AM Uchida, EK Boden, EA James, DM Shows, AJ Konecny, J D.
CMGH Cellular and Molecular Gastroenterology and Hepatology 2020
CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
A Greenshields-Watson, M Attaf, BJ MacLachlan, T Whalley, C Rius, A Wall, A Lloyd, H Hughes, KE Strange, GH Mason, AJ Schauenburg, SL Hulin-Curtis, J Geary, Y Chen, SN Lauder, K Smart, D Vijaykrishna, ML Grau, M Shugay, R Andrews, G Dolton, PJ Rizkallah, AM Gallimore, AK Sewell, AJ Godkin, DK Cole
Cell Reports 2020
A Conserved TCRβ Signature Dominates a Highly Polyclonal T-Cell Expansion During the Acute Phase of a Murine Malaria Infection
NL Smith, W Nahrendorf, C Sutherland, JP Mooney, J Thompson, PJ Spence, GJ Cowan
Frontiers in immunology 2020
T-cell receptor repertoire of cytomegalovirus-specific cytotoxic T-cells after allogeneic stem cell transplantation
T Toya, A Taguchi, K Kitaura, F Misumi, Y Nakajima, Y Otsuka, R Konuma, H Adachi, A Wada, Y Kishida, T Konishi, A Nagata, Y Yamada, A Marumo, Y Noguchi, K Yoshifuji, J Mukae, K Inamoto, A Igarashi, Y Najima, T Kobayashi, K Kakihana, K Ohashi, R Suzuki, T Nagamatsu, N Doki
Scientific Reports 2020
T-cell receptor sequencing demonstrates persistence of virus-specific T cells after antiviral immunotherapy: TCR Sequencing of Virus-specific T-cells
MD Keller, S Darko, H Lang, A Ransier, CA Lazarski, Y Wang, PJ Hanley, BJ Davila, JR Heimall, RF Ambinder, AJ Barrett, CM Rooney, HE Heslop, DC Douek, CM Bollard
British Journal of Haematology 2019
Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection
L Li, Y Liu, MK Gorny
Frontiers in immunology 2018
A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers
M Claireaux, M Galperin, D Benati, A Nouël, M Mukhopadhyay, J Klingler, P Truchis, D Zucman, S Hendou, F Boufassa, C Moog, O Lambotte, LA Chakrabarti, V Simon, P Palese
mBio 2018
Understanding the CD8 T-cell response in natural HIV control
S Boppana, P Goepfert
F1000Research 2018
T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable
AV Joglekar, Z Liu, JK Weber, Y Ouyang, JD Jeppson, WJ Noh, PA Lamothe-Molina, H Chen, S Kang, MT Bethune, R Zhou, BD Walker, D Baltimore
Proceedings of the National Academy of Sciences 2018
Dendritic Cell Immune Responses in HIV-1 Controllers
E Martin-Gayo, XG Yu
Current HIV/AIDS Reports 2017
Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance
MS Abdel-Hakeem, M Boisvert, J Bruneau, H Soudeyns, NH Shoukry, G Randall
PLoS pathogens 2017
HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
A Rouers, J Klingler, B Su, A Samri, G Laumond, S Even, V Avettand-Fenoel, C Richetta, N Paul, F Boufassa, L Hocqueloux, H Mouquet, C Rouzioux, O Lambotte, B Autran, S Graff-Dubois, C Moog, A Moris
EBioMedicine 2017
High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities
JM Heather, M Ismail, T Oakes, B Chain
Briefings in Bioinformatics 2017
Chronic infections with viruses or parasites: breaking bad to make good
A Godkin, KA Smith
Immunology 2017
DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers
M Mukhopadhyay, M Galperin, M Patgaonkar, S Vasan, DD Ho, A Nouël, M Claireaux, D Benati, O Lambotte, Y Huang, LA Chakrabarti
Journal of immunology (Baltimore, Md. : 1950) 2017
MHC Class II Tetramer Labeling of Human Primary CD4+ T Cells from HIV Infected Patients
M Galperin, D Benati, M Claireaux, M Mukhopadhyay, L Chakrabarti
Bio-protocol 2017
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
S Ranasinghe, PA Lamothe, DZ Soghoian, SW Kazer, MB Cole, AK Shalek, N Yosef, RB Jones, F Donaghey, C Nwonu, P Jani, GM Clayton, F Crawford, J White, A Montoya, K Power, TM Allen, H Streeck, DE Kaufmann, LJ Picker, JW Kappler, BD Walker
Immunity 2016

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 15 news outlets
Blogged by 3
Posted by 6 X users
Referenced in 3 patents
On 2 Facebook pages
Referenced in 1 Wikipedia pages
Mentioned in 1 Google+ posts
Highlighted by 1 platforms
97 readers on Mendeley
See more details